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- W3024165459 abstract "Abstract The lipid composition of organelles acts as a landmark to define membrane identity and specify subcellular function. Phosphoinositides are anionic lipids acting in protein sorting and trafficking at the trans -Golgi network (TGN). In animal cells, sphingolipids are known to control the turnover of phosphoinositides through lipid exchange mechanisms at endoplasmic reticulum/TGN contact sites. In this study, we discovered a completely new mechanism acting on sphingolipid-mediated phosphoinositides homeostasis at the TGN in plant cells. We used multi-approaches to show that a reduction of the acyl-chain length of sphingolipid results in increased level of phosphatidylinositol-4-phosphate (PI4P) at the TGN, independently from either lipid exchange induced by sphingolipid synthetic flux, or local PI4P synthesis. Instead, we found that sphingolipids mediate the consumption of PI4P through phosphoinositide-specific phospholipase C (PI-PLC) and this process impacts the sorting of the auxin efflux carrier PIN2 at the TGN. Together, our data identify a new mode of action of sphingolipids in lipid interplay at the TGN during protein sorting." @default.
- W3024165459 created "2020-05-21" @default.
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- W3024165459 date "2020-05-14" @default.
- W3024165459 modified "2023-10-18" @default.
- W3024165459 title "Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at thetrans-Golgi Network" @default.
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- W3024165459 doi "https://doi.org/10.1101/2020.05.12.090399" @default.
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