Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024208367> ?p ?o ?g. }
- W3024208367 abstract "Abstract The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this study, we analyze the genomic markers, genes, gene ontology and biological pathways associated with the presence of aggressive/checking, symmetry/order, contamination/cleaning, hoarding, and sexual/religious symptoms, as assessed via the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) in 399 probands. Logistic regression analyses were performed at the single-nucleotide polymorphism (SNP) level. Gene-based and enrichment analyses were carried out for common (SNPs) and rare variants. No SNP was associated with any dimension at a genome-wide level ( p < 5 × 10 −8 ). Gene-based analyses showed one gene to be associated with hoarding ( SETD3 , p = 1.89 × 10 −08 ); a gene highly expressed in the brain and which plays a role in apoptotic processes and transcriptomic changes, and another gene associated with aggressive symptoms ( CPE ; p = 4.42 × 10 −6 ), which is involved in neurotrophic functions and the synthesis of peptide hormones and neurotransmitters. Different pathways or biological processes were represented by genes associated with aggressive (zinc ion response and lipid metabolism), order (lipid metabolism), sexual/religious (G protein-mediated processes) and hoarding (metabolic processes and anion transport) symptoms after FDR correction; while no pathway was associated with contamination. Specific genomic bases were found for each dimension assessed, especially in the enrichment analyses. Further research with larger samples and different techniques, such as next-generation sequencing, are needed to better understand the differential genetics of OCD dimensions." @default.
- W3024208367 created "2020-05-21" @default.
- W3024208367 creator A5007565693 @default.
- W3024208367 creator A5010864204 @default.
- W3024208367 creator A5019440791 @default.
- W3024208367 creator A5033298926 @default.
- W3024208367 creator A5077296737 @default.
- W3024208367 creator A5086084955 @default.
- W3024208367 creator A5086564358 @default.
- W3024208367 creator A5090625854 @default.
- W3024208367 creator A5091790444 @default.
- W3024208367 date "2020-05-18" @default.
- W3024208367 modified "2023-10-16" @default.
- W3024208367 title "Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study" @default.
- W3024208367 cites W129745045 @default.
- W3024208367 cites W1581852181 @default.
- W3024208367 cites W1692343651 @default.
- W3024208367 cites W1967699033 @default.
- W3024208367 cites W1972764180 @default.
- W3024208367 cites W1979329685 @default.
- W3024208367 cites W1979906070 @default.
- W3024208367 cites W1980737710 @default.
- W3024208367 cites W1986380371 @default.
- W3024208367 cites W1988766708 @default.
- W3024208367 cites W2000404485 @default.
- W3024208367 cites W2001836680 @default.
- W3024208367 cites W2010805579 @default.
- W3024208367 cites W2017651040 @default.
- W3024208367 cites W2027498758 @default.
- W3024208367 cites W2028076640 @default.
- W3024208367 cites W2031589588 @default.
- W3024208367 cites W2032191302 @default.
- W3024208367 cites W2032755846 @default.
- W3024208367 cites W2035447817 @default.
- W3024208367 cites W2035477798 @default.
- W3024208367 cites W2035919073 @default.
- W3024208367 cites W2039883051 @default.
- W3024208367 cites W2041915741 @default.
- W3024208367 cites W2048617028 @default.
- W3024208367 cites W2057869480 @default.
- W3024208367 cites W2062119354 @default.
- W3024208367 cites W2068317483 @default.
- W3024208367 cites W2077823633 @default.
- W3024208367 cites W2085872855 @default.
- W3024208367 cites W2093377309 @default.
- W3024208367 cites W2095248779 @default.
- W3024208367 cites W2097021742 @default.
- W3024208367 cites W2099856240 @default.
- W3024208367 cites W2100861230 @default.
- W3024208367 cites W2107655107 @default.
- W3024208367 cites W2111388194 @default.
- W3024208367 cites W2112044919 @default.
- W3024208367 cites W2113562236 @default.
- W3024208367 cites W2113684838 @default.
- W3024208367 cites W2113728266 @default.
- W3024208367 cites W2118837266 @default.
- W3024208367 cites W2123822033 @default.
- W3024208367 cites W2128134143 @default.
- W3024208367 cites W2128250859 @default.
- W3024208367 cites W2133465414 @default.
- W3024208367 cites W2134912602 @default.
- W3024208367 cites W2144516269 @default.
- W3024208367 cites W2145716676 @default.
- W3024208367 cites W2152199882 @default.
- W3024208367 cites W2158217645 @default.
- W3024208367 cites W2161245845 @default.
- W3024208367 cites W2161633633 @default.
- W3024208367 cites W2163013660 @default.
- W3024208367 cites W2163953557 @default.
- W3024208367 cites W2163963963 @default.
- W3024208367 cites W2167898988 @default.
- W3024208367 cites W2294181977 @default.
- W3024208367 cites W2297491466 @default.
- W3024208367 cites W2317029201 @default.
- W3024208367 cites W2330364156 @default.
- W3024208367 cites W2462597493 @default.
- W3024208367 cites W2467891708 @default.
- W3024208367 cites W2560791331 @default.
- W3024208367 cites W2582351799 @default.
- W3024208367 cites W2597448237 @default.
- W3024208367 cites W2606457199 @default.
- W3024208367 cites W2611270005 @default.
- W3024208367 cites W2612522258 @default.
- W3024208367 cites W2626046544 @default.
- W3024208367 cites W2626497039 @default.
- W3024208367 cites W2742103013 @default.
- W3024208367 cites W2766926863 @default.
- W3024208367 cites W2767853819 @default.
- W3024208367 cites W2768696612 @default.
- W3024208367 cites W2793969991 @default.
- W3024208367 cites W2794134966 @default.
- W3024208367 cites W2802580180 @default.
- W3024208367 cites W2898277945 @default.
- W3024208367 cites W2906125270 @default.
- W3024208367 cites W2908580509 @default.
- W3024208367 cites W2914151665 @default.
- W3024208367 cites W2921670180 @default.
- W3024208367 cites W2922597828 @default.
- W3024208367 cites W2929133467 @default.
- W3024208367 cites W2942755459 @default.