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• W3024211207 endingPage "264" @default.
• W3024211207 startingPage "254" @default.
• W3024211207 abstract "Antidepressants (ADs) are the main clinical therapy for depression, but approximately half of users do not get adequate response. The biallelic (5-HTTLPR) and triallelic (5-HTTLPR/rs25531) polymorphisms in SLC6A4 have been frequently investigated, but their associations with ADs response are in controversy. Here, we performed a meta-analysis to assess their modulation effect to ADs response in major depressive disorder (MDD). We performed literature search in PubMed, Web of Science and EMBASE before June 2019. Pooled analysis of genetic associations with response and remission, meta-regression and sensitivity analysis were performed, and publication bias was assessed. Literature search yielded 49 eligible studies with 46 and 10 studies for biallelic and triallelic polymorphism, respectively. L allele of 5-HTTLPR was associated with both of response and remission rates. In the Caucasians using SSRIs only, carriers of LL/LS or LL genotype were more likely to be responders compared to SS carriers (LL/LS vs. SS: OR=1.55, 95%CI 1.20-2.00, p=0.001; LL vs. SS: OR=1.97, 95%CI 1.45-2.67, p<0.001). Similar associations were also found with remission rate. However, no effects on response or remission were found in the Asians or mixed/other antidepressant subgroups. Additionally, the 5-HTTLPR/rs25531 triallelic polymorphism may not associate with ADs response. Meta-regression showed that percent of female in participants, year of publication and treatment duration modulated the association in Caucasians. 5-HTTLPR, instead of 5-HTTLPR/rs25531 triallelic polymorphism, may exert as a marker for the prediction of response to SSRIs in Caucasians with MDD." @default.
• W3024211207 created "2020-05-21" @default.
• W3024211207 creator A5000359400 @default.
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• W3024211207 creator A5041497074 @default.
• W3024211207 creator A5068058669 @default.
• W3024211207 creator A5070584261 @default.
• W3024211207 date "2020-08-01" @default.
• W3024211207 modified "2023-10-10" @default.
• W3024211207 title "Pharmacogenetic association of bi- and triallelic polymorphisms of SLC6A4 with antidepressant response in major depressive disorder" @default.
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• W3024211207 doi "https://doi.org/10.1016/j.jad.2020.04.058" @default.
• W3024211207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32421611" @default.
• W3024211207 hasPublicationYear "2020" @default.
• W3024211207 type Work @default.
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