FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024223854> ?p ?o ?g. }

• W3024223854 abstract "Abstract Although uterine leiomyomas are the most common benign uterine tumors in women, there is no effective therapy that can also preserve the uterus and maintain fertility. The work aimed to work was to discover a potential natural agent that has pharmacological activities on uterine leiomyomas with fewer adverse effects. We chose Rhus verniciflua Stokes (RVS) as a candidate after primary cytotoxicity testing, and analyzed the RVS components that showed pharmacological activity. Leiomyoma cells and myometrium cells were cultured from uterine tissues obtained from patients, and were treated with RVS at varying concentrations. RVS was cytotoxic in both leiomyoma and myometrium cells; however, the effects were more prominent in the leiomyoma cells. Among the bioactive components of RVS, fisetin showed significant pharmacological effects on leiomyoma cells. Fisetin showed excellent leiomyoma cell cytotoxicity and induced apoptotic cell death with cell cycle arrest. The apoptotic cell death appeared to involve not one specific pathway but multichannel pathways (intrinsic, extrinsic, MARK, and p53-mediated pathways), and autophagy. The multichannel apoptosis pathways were activated with a low concentration of fisetin (<IC 20 ) and were more vigorously activated at high concentrations (>IC 50 ). This is the first demonstration to show the pharmacological activities of fisetin on leiomyoma cells. These findings suggest that fisetin may be used for the prevention and treatment of uterine leiomyomas. Since fisetin can be obtained from plants, it may be a safe and effective alternative treatment for uterine leiomyomas." @default.
• W3024223854 created "2020-05-21" @default.
• W3024223854 creator A5014751354 @default.
• W3024223854 creator A5019643217 @default.
• W3024223854 creator A5044174536 @default.
• W3024223854 creator A5055445732 @default.
• W3024223854 creator A5089566183 @default.
• W3024223854 creator A5091466840 @default.
• W3024223854 date "2020-05-14" @default.
• W3024223854 modified "2023-09-27" @default.
• W3024223854 title "Fisetin induces apoptosis in uterine leiomyomas through multiple pathways" @default.
• W3024223854 cites W1967828043 @default.
• W3024223854 cites W1970061639 @default.
• W3024223854 cites W1970864772 @default.
• W3024223854 cites W1976881265 @default.
• W3024223854 cites W1981957259 @default.
• W3024223854 cites W1988439004 @default.
• W3024223854 cites W2008757142 @default.
• W3024223854 cites W2008758386 @default.
• W3024223854 cites W2026372373 @default.
• W3024223854 cites W2042407426 @default.
• W3024223854 cites W2054288703 @default.
• W3024223854 cites W2063685395 @default.
• W3024223854 cites W2065078698 @default.
• W3024223854 cites W2066113694 @default.
• W3024223854 cites W2085460220 @default.
• W3024223854 cites W2096308078 @default.
• W3024223854 cites W2097830998 @default.
• W3024223854 cites W2100093977 @default.
• W3024223854 cites W2102870521 @default.
• W3024223854 cites W2106587450 @default.
• W3024223854 cites W2140844543 @default.
• W3024223854 cites W2143093423 @default.
• W3024223854 cites W2145519498 @default.
• W3024223854 cites W2150077646 @default.
• W3024223854 cites W2154693051 @default.
• W3024223854 cites W2165845483 @default.
• W3024223854 cites W2167525817 @default.
• W3024223854 cites W2276027104 @default.
• W3024223854 cites W2343152138 @default.
• W3024223854 cites W2528348212 @default.
• W3024223854 cites W2758797028 @default.
• W3024223854 cites W2760887818 @default.
• W3024223854 cites W2769768316 @default.
• W3024223854 cites W2796592069 @default.
• W3024223854 cites W2889010309 @default.
• W3024223854 cites W2907645203 @default.
• W3024223854 cites W314008413 @default.
• W3024223854 cites W908783740 @default.
• W3024223854 doi "https://doi.org/10.1038/s41598-020-64871-y" @default.
• W3024223854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7224361" @default.
• W3024223854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32409692" @default.
• W3024223854 hasPublicationYear "2020" @default.
• W3024223854 type Work @default.
• W3024223854 sameAs 3024223854 @default.
• W3024223854 citedByCount "7" @default.
• W3024223854 countsByYear W30242238542021 @default.
• W3024223854 countsByYear W30242238542022 @default.
• W3024223854 countsByYear W30242238542023 @default.
• W3024223854 crossrefType "journal-article" @default.
• W3024223854 hasAuthorship W3024223854A5014751354 @default.
• W3024223854 hasAuthorship W3024223854A5019643217 @default.
• W3024223854 hasAuthorship W3024223854A5044174536 @default.
• W3024223854 hasAuthorship W3024223854A5055445732 @default.
• W3024223854 hasAuthorship W3024223854A5089566183 @default.
• W3024223854 hasAuthorship W3024223854A5091466840 @default.
• W3024223854 hasBestOaLocation W30242238541 @default.
• W3024223854 hasConcept C126322002 @default.
• W3024223854 hasConcept C134018914 @default.
• W3024223854 hasConcept C142724271 @default.
• W3024223854 hasConcept C185592680 @default.
• W3024223854 hasConcept C190283241 @default.
• W3024223854 hasConcept C2777376040 @default.
• W3024223854 hasConcept C2777795800 @default.
• W3024223854 hasConcept C2778004101 @default.
• W3024223854 hasConcept C2778164554 @default.
• W3024223854 hasConcept C2779054382 @default.
• W3024223854 hasConcept C2779066055 @default.
• W3024223854 hasConcept C3017725331 @default.
• W3024223854 hasConcept C31573885 @default.
• W3024223854 hasConcept C502942594 @default.
• W3024223854 hasConcept C55493867 @default.
• W3024223854 hasConcept C71924100 @default.
• W3024223854 hasConcept C86803240 @default.
• W3024223854 hasConcept C98274493 @default.
• W3024223854 hasConceptScore W3024223854C126322002 @default.
• W3024223854 hasConceptScore W3024223854C134018914 @default.
• W3024223854 hasConceptScore W3024223854C142724271 @default.
• W3024223854 hasConceptScore W3024223854C185592680 @default.
• W3024223854 hasConceptScore W3024223854C190283241 @default.
• W3024223854 hasConceptScore W3024223854C2777376040 @default.
• W3024223854 hasConceptScore W3024223854C2777795800 @default.
• W3024223854 hasConceptScore W3024223854C2778004101 @default.
• W3024223854 hasConceptScore W3024223854C2778164554 @default.
• W3024223854 hasConceptScore W3024223854C2779054382 @default.
• W3024223854 hasConceptScore W3024223854C2779066055 @default.
• W3024223854 hasConceptScore W3024223854C3017725331 @default.
• W3024223854 hasConceptScore W3024223854C31573885 @default.
• W3024223854 hasConceptScore W3024223854C502942594 @default.
• W3024223854 hasConceptScore W3024223854C55493867 @default.

• next