Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024239644> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3024239644 endingPage "180" @default.
- W3024239644 startingPage "175" @default.
- W3024239644 abstract "To observe the clinical curative effect of Qingying Tang in the treatment of psoriatic blood-heat syndrome and explore its intrinsic mechanism.In this study,we collected 72 patients with blood-heat syndrome psoriasis admitted to our dermatology clinic from January 2016 to December 2017 and divided into control group and observation group according to the random number table method,36 cases in each group.The patients in control group were given with Acitretin Capsules orally,10 mg/time,twice a day.The patients in observation group were given with Qingying Tang orally,150 mL/time,twice a day.The treatment period was 12 weeks in both groups.The traditional Chinese medicine(TCM) syndrome scores before and after treatment,psoriasis area and severity index(PASI) score,dermatology life quality index(DLQI) score,and the clinical efficacy of the two groups were compared between the two groups;flow cytometry was used to detect peripheral blood Th17 cell percentages before and after treatment in both groups;serum interleukin(IL)-17,IL-23,IL-22,and IL-21 levels in both groups before and after treatment were measured by ELISA;the expression levels of STAT3 and RORγt before and after treatment in patients were measured by using skin lesion immunohistochemical method.The results showed that the TCM symptoms were improved significantly in both groups(P<0.05),and the effect in observation group was significantly better than that in the control group(P<0.05).PASI and DLQI scores were decreased significantly after treatment in both groups(P<0.05),and the scores in observation group were significantly lower than those in the control group(P<0.05).The curative effect of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the percentage of Th17 cells,as well as IL-17,IL-23,IL-22 and IL-21 levels in peripheral blood were significantly decreased in both groups(P<0.05),and the levels in observation group were significantly lower than those in the control group(P<0.05).The expression levels of STAT3 and RORγt in both groups were significantly lower than those before treatment(P<0.01),and the levels in observation group were significantly lower than those in the control group(P<0.05).All of the results indicted that Qingying Tang can effectively improve the skin lesions and TCM syndrome in patients with psoriasis and blood-heat syndrome,and improve patient health quality,which may be related to regulation of peripheral blood IL-23/Th17." @default.
- W3024239644 created "2020-05-21" @default.
- W3024239644 creator A5012278873 @default.
- W3024239644 creator A5013364296 @default.
- W3024239644 creator A5016918591 @default.
- W3024239644 creator A5019504710 @default.
- W3024239644 creator A5045110678 @default.
- W3024239644 creator A5073802664 @default.
- W3024239644 date "2019-01-01" @default.
- W3024239644 modified "2023-09-22" @default.
- W3024239644 title "[Study on clinical efficacy and mechanism of Qingying Tang for treating psoriatic blood-heat syndrome based on IL-23/Th17]." @default.
- W3024239644 doi "https://doi.org/10.19540/j.cnki.cjcmm.20180709.001" @default.
- W3024239644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30868829" @default.
- W3024239644 hasPublicationYear "2019" @default.
- W3024239644 type Work @default.
- W3024239644 sameAs 3024239644 @default.
- W3024239644 citedByCount "4" @default.
- W3024239644 countsByYear W30242396442019 @default.
- W3024239644 countsByYear W30242396442022 @default.
- W3024239644 countsByYear W30242396442023 @default.
- W3024239644 crossrefType "journal-article" @default.
- W3024239644 hasAuthorship W3024239644A5012278873 @default.
- W3024239644 hasAuthorship W3024239644A5013364296 @default.
- W3024239644 hasAuthorship W3024239644A5016918591 @default.
- W3024239644 hasAuthorship W3024239644A5019504710 @default.
- W3024239644 hasAuthorship W3024239644A5045110678 @default.
- W3024239644 hasAuthorship W3024239644A5073802664 @default.
- W3024239644 hasConcept C126322002 @default.
- W3024239644 hasConcept C139572402 @default.
- W3024239644 hasConcept C141071460 @default.
- W3024239644 hasConcept C142724271 @default.
- W3024239644 hasConcept C16005928 @default.
- W3024239644 hasConcept C188947578 @default.
- W3024239644 hasConcept C204787440 @default.
- W3024239644 hasConcept C2776173921 @default.
- W3024239644 hasConcept C2777011040 @default.
- W3024239644 hasConcept C2778163477 @default.
- W3024239644 hasConcept C2778690821 @default.
- W3024239644 hasConcept C2780564577 @default.
- W3024239644 hasConcept C2781156865 @default.
- W3024239644 hasConcept C47348012 @default.
- W3024239644 hasConcept C71924100 @default.
- W3024239644 hasConcept C90924648 @default.
- W3024239644 hasConceptScore W3024239644C126322002 @default.
- W3024239644 hasConceptScore W3024239644C139572402 @default.
- W3024239644 hasConceptScore W3024239644C141071460 @default.
- W3024239644 hasConceptScore W3024239644C142724271 @default.
- W3024239644 hasConceptScore W3024239644C16005928 @default.
- W3024239644 hasConceptScore W3024239644C188947578 @default.
- W3024239644 hasConceptScore W3024239644C204787440 @default.
- W3024239644 hasConceptScore W3024239644C2776173921 @default.
- W3024239644 hasConceptScore W3024239644C2777011040 @default.
- W3024239644 hasConceptScore W3024239644C2778163477 @default.
- W3024239644 hasConceptScore W3024239644C2778690821 @default.
- W3024239644 hasConceptScore W3024239644C2780564577 @default.
- W3024239644 hasConceptScore W3024239644C2781156865 @default.
- W3024239644 hasConceptScore W3024239644C47348012 @default.
- W3024239644 hasConceptScore W3024239644C71924100 @default.
- W3024239644 hasConceptScore W3024239644C90924648 @default.
- W3024239644 hasIssue "1" @default.
- W3024239644 hasLocation W30242396441 @default.
- W3024239644 hasOpenAccess W3024239644 @default.
- W3024239644 hasPrimaryLocation W30242396441 @default.
- W3024239644 hasRelatedWork W1998668025 @default.
- W3024239644 hasRelatedWork W2185003370 @default.
- W3024239644 hasRelatedWork W2380806412 @default.
- W3024239644 hasRelatedWork W2766413417 @default.
- W3024239644 hasRelatedWork W2767862884 @default.
- W3024239644 hasRelatedWork W2800913701 @default.
- W3024239644 hasRelatedWork W2897672480 @default.
- W3024239644 hasRelatedWork W2911012132 @default.
- W3024239644 hasRelatedWork W3024239644 @default.
- W3024239644 hasRelatedWork W3033158965 @default.
- W3024239644 hasVolume "44" @default.
- W3024239644 isParatext "false" @default.
- W3024239644 isRetracted "false" @default.
- W3024239644 magId "3024239644" @default.
- W3024239644 workType "article" @default.