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- W3024252005 startingPage "9686" @default.
- W3024252005 abstract "Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is one of the first organs to age, ovulation and ovarian wound healing is impaired with advanced reproductive age. To test this hypothesis, we induced superovulation in reproductively young and old mice and determined the numbers of eggs ovulated and corpora lutea (CLs), the progesterone producing glands formed post-ovulation. Reproductively old mice ovulated fewer eggs and had fewer CLs relative to young controls. Moreover, reproductively old mice exhibited a greater number of oocytes trapped within CLs and expanded cumulus oocyte complexes within unruptured antral follicles, indicative of failed ovulation. In addition, post-ovulatory tissue remodeling was compromised with age as evidenced by reduced CL vasculature, increased collagen, decreased hyaluronan, decreased cell proliferation and apoptosis, impaired wound healing capacity, and aberrant morphology of the ovarian surface epithelium (OSE). These findings demonstrate that ovulatory dysfunction is an additional mechanism underlying the age-related loss of fertility beyond the reduction of egg quantity and quality." @default.
- W3024252005 created "2020-05-21" @default.
- W3024252005 creator A5005810574 @default.
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- W3024252005 creator A5070667458 @default.
- W3024252005 creator A5090840926 @default.
- W3024252005 date "2020-05-14" @default.
- W3024252005 modified "2023-10-16" @default.
- W3024252005 title "Ovulation and ovarian wound healing are impaired with advanced reproductive age" @default.
- W3024252005 cites W1512733937 @default.
- W3024252005 cites W1516197969 @default.
- W3024252005 cites W177958585 @default.
- W3024252005 cites W1839299040 @default.
- W3024252005 cites W1964081206 @default.
- W3024252005 cites W1974208182 @default.
- W3024252005 cites W1978106872 @default.
- W3024252005 cites W1988106795 @default.
- W3024252005 cites W1990911325 @default.
- W3024252005 cites W2006196877 @default.
- W3024252005 cites W2016540525 @default.
- W3024252005 cites W2019880257 @default.
- W3024252005 cites W2024821721 @default.
- W3024252005 cites W2028424919 @default.
- W3024252005 cites W2030042776 @default.
- W3024252005 cites W2037333439 @default.
- W3024252005 cites W2039411737 @default.
- W3024252005 cites W2045142779 @default.
- W3024252005 cites W2047083811 @default.
- W3024252005 cites W2050603997 @default.
- W3024252005 cites W2050910224 @default.
- W3024252005 cites W2055130200 @default.
- W3024252005 cites W2055502077 @default.
- W3024252005 cites W2059213440 @default.
- W3024252005 cites W2065864082 @default.
- W3024252005 cites W2070053101 @default.
- W3024252005 cites W2073325756 @default.
- W3024252005 cites W2074506507 @default.
- W3024252005 cites W2077429419 @default.
- W3024252005 cites W2081160763 @default.
- W3024252005 cites W2082177709 @default.
- W3024252005 cites W2082559087 @default.
- W3024252005 cites W2090018250 @default.
- W3024252005 cites W2098124125 @default.
- W3024252005 cites W2102323056 @default.
- W3024252005 cites W2108067228 @default.
- W3024252005 cites W2109760209 @default.
- W3024252005 cites W2110562063 @default.
- W3024252005 cites W2112396222 @default.
- W3024252005 cites W2117328083 @default.
- W3024252005 cites W2124121505 @default.
- W3024252005 cites W2126466142 @default.
- W3024252005 cites W2131438183 @default.
- W3024252005 cites W2136949042 @default.
- W3024252005 cites W2138003270 @default.
- W3024252005 cites W2139966914 @default.
- W3024252005 cites W2139978393 @default.
- W3024252005 cites W2140551998 @default.
- W3024252005 cites W2140998974 @default.
- W3024252005 cites W2143149490 @default.
- W3024252005 cites W2143890630 @default.
- W3024252005 cites W2149556864 @default.
- W3024252005 cites W2151396736 @default.
- W3024252005 cites W2155358741 @default.
- W3024252005 cites W2157077875 @default.
- W3024252005 cites W2158304398 @default.
- W3024252005 cites W2264343275 @default.
- W3024252005 cites W2278264011 @default.
- W3024252005 cites W2311248722 @default.
- W3024252005 cites W2323847176 @default.
- W3024252005 cites W2497766038 @default.
- W3024252005 cites W2498125942 @default.
- W3024252005 cites W2515590801 @default.
- W3024252005 cites W2523712370 @default.
- W3024252005 cites W2550080559 @default.
- W3024252005 cites W2558795141 @default.
- W3024252005 cites W2560606601 @default.
- W3024252005 cites W2567221680 @default.
- W3024252005 cites W2597980329 @default.
- W3024252005 cites W2613163105 @default.
- W3024252005 cites W2733082701 @default.
- W3024252005 cites W2751619916 @default.
- W3024252005 cites W2764279830 @default.
- W3024252005 cites W2766975851 @default.
- W3024252005 cites W2796617071 @default.
- W3024252005 cites W2903464283 @default.
- W3024252005 cites W2949577358 @default.
- W3024252005 cites W2964124114 @default.
- W3024252005 cites W2966193542 @default.
- W3024252005 cites W2972344212 @default.
- W3024252005 cites W2973605206 @default.
- W3024252005 cites W2975751760 @default.
- W3024252005 cites W2979808878 @default.
- W3024252005 cites W2985676661 @default.
- W3024252005 cites W2988755269 @default.