FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024286687> ?p ?o ?g. }

• W3024286687 endingPage "114613" @default.
• W3024286687 startingPage "114613" @default.
• W3024286687 abstract "Cadmium (Cd) is a toxic heavy metal and widespread in environment and food, which is adverse to human and animal health. Food intervention is a hot topic because it has no side effects. Selenium (Se) is an essential trace element, found in various fruits and vegetables. Many previous papers have described that Se showed ameliorative effects against Cd. However, the underlying mechanism of antagonistic effect of Se against Cd-induced cytotoxicity in avian leghorn male hepatoma (LMH) cells is unknown, the molecular mechanism of Se antagonistic effect on Cd-induced and calcium (Ca2+) homeostasis disorder and crosstalk of ER stress and autophagy remain to be explored. In order to confirm the antagonistic effect of Se on Cd-induced LMH cell toxicity, LMH cells were treated with CdCl2 (2.5 μM) and Na2SeO3 (1.25 and 2.5 μM) for 24 h. In this study, Cd exposure induced cell death, disrupted intracellular Ca2+ homeostasis and Ca2+ homeostasis related regulatory factors, interfered with the cycle of cadherin (CNX)/calreticulin (CRT), and triggered ER stress and autophagy. Se intervention inhibited Cd-induced LDH release and crosstalk of ER stress and autophagy via regulating intracellular Ca2+ homeostasis. Moreover, Se mitigated Cd-induced Intracellular Ca2+ overload by Ca2+/calmodulin (CaM)/calmodulin kinase IV (CaMK-IV) signaling pathway. Herein, CNX/CRT cycle played a critical role for the protective effect of Se on Cd-induced hepatotoxicity. Based on these findings, we demonstrated that the application of Se is beneficial for prevention and alleviation of Cd toxicity." @default.
• W3024286687 created "2020-05-21" @default.
• W3024286687 creator A5015105154 @default.
• W3024286687 creator A5019654197 @default.
• W3024286687 creator A5023492006 @default.
• W3024286687 creator A5070810950 @default.
• W3024286687 creator A5074734978 @default.
• W3024286687 creator A5086155499 @default.
• W3024286687 date "2020-10-01" @default.
• W3024286687 modified "2023-10-16" @default.
• W3024286687 title "Selenium mitigates cadmium-induced crosstalk between autophagy and endoplasmic reticulum stress via regulating calcium homeostasis in avian leghorn male hepatoma (LMH) cells" @default.
• W3024286687 cites W1261152366 @default.
• W3024286687 cites W1564633294 @default.
• W3024286687 cites W1642054912 @default.
• W3024286687 cites W1821077834 @default.
• W3024286687 cites W1868173438 @default.
• W3024286687 cites W1974516883 @default.
• W3024286687 cites W1983760632 @default.
• W3024286687 cites W2003650736 @default.
• W3024286687 cites W2004816473 @default.
• W3024286687 cites W2021224958 @default.
• W3024286687 cites W2029169169 @default.
• W3024286687 cites W2033968745 @default.
• W3024286687 cites W2034972226 @default.
• W3024286687 cites W2037439168 @default.
• W3024286687 cites W2037700816 @default.
• W3024286687 cites W2039389972 @default.
• W3024286687 cites W2044241702 @default.
• W3024286687 cites W2048099887 @default.
• W3024286687 cites W2060151133 @default.
• W3024286687 cites W2065330934 @default.
• W3024286687 cites W2066660728 @default.
• W3024286687 cites W2088629624 @default.
• W3024286687 cites W2089609187 @default.
• W3024286687 cites W2099579977 @default.
• W3024286687 cites W2117875646 @default.
• W3024286687 cites W2135256812 @default.
• W3024286687 cites W2136725886 @default.
• W3024286687 cites W2139215121 @default.
• W3024286687 cites W2140044977 @default.
• W3024286687 cites W2159518229 @default.
• W3024286687 cites W2168420558 @default.
• W3024286687 cites W2174428414 @default.
• W3024286687 cites W2177037818 @default.
• W3024286687 cites W2277468569 @default.
• W3024286687 cites W2397406137 @default.
• W3024286687 cites W2507586450 @default.
• W3024286687 cites W2561049301 @default.
• W3024286687 cites W2568995659 @default.
• W3024286687 cites W2590576504 @default.
• W3024286687 cites W2610509982 @default.
• W3024286687 cites W2618876324 @default.
• W3024286687 cites W2741550138 @default.
• W3024286687 cites W2744123648 @default.
• W3024286687 cites W2748137738 @default.
• W3024286687 cites W2750730703 @default.
• W3024286687 cites W2765938165 @default.
• W3024286687 cites W2769124173 @default.
• W3024286687 cites W2780491137 @default.
• W3024286687 cites W2793127373 @default.
• W3024286687 cites W2804116577 @default.
• W3024286687 cites W2806564438 @default.
• W3024286687 cites W2810649304 @default.
• W3024286687 cites W2864773961 @default.
• W3024286687 cites W2883071172 @default.
• W3024286687 cites W2890781920 @default.
• W3024286687 cites W2895294863 @default.
• W3024286687 cites W2897209515 @default.
• W3024286687 cites W2898143986 @default.
• W3024286687 cites W2920385976 @default.
• W3024286687 cites W2940786643 @default.
• W3024286687 cites W2944542143 @default.
• W3024286687 cites W2945727442 @default.
• W3024286687 cites W2954953292 @default.
• W3024286687 cites W2963795702 @default.
• W3024286687 cites W2970014014 @default.
• W3024286687 cites W2993012387 @default.
• W3024286687 cites W2998405527 @default.
• W3024286687 cites W2999257475 @default.
• W3024286687 cites W3001914730 @default.
• W3024286687 cites W3004711592 @default.
• W3024286687 cites W3005139361 @default.
• W3024286687 cites W395707825 @default.
• W3024286687 doi "https://doi.org/10.1016/j.envpol.2020.114613" @default.
• W3024286687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32504893" @default.
• W3024286687 hasPublicationYear "2020" @default.
• W3024286687 type Work @default.
• W3024286687 sameAs 3024286687 @default.
• W3024286687 citedByCount "38" @default.
• W3024286687 countsByYear W30242866872020 @default.
• W3024286687 countsByYear W30242866872021 @default.
• W3024286687 countsByYear W30242866872022 @default.
• W3024286687 countsByYear W30242866872023 @default.
• W3024286687 crossrefType "journal-article" @default.
• W3024286687 hasAuthorship W3024286687A5015105154 @default.
• W3024286687 hasAuthorship W3024286687A5019654197 @default.
• W3024286687 hasAuthorship W3024286687A5023492006 @default.
• W3024286687 hasAuthorship W3024286687A5070810950 @default.

• next