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• W3024291246 abstract "Abstract Several diseases and disorders have been suggested to be associated with zinc deficiency, especially learning and memory impairment. To have better understanding about the connection between lipid changes and cognitive impairments, we investigated the effects of a zinc‐chelated diet on certain brain lipids of Drosophila melanogaster by using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). The data revealed that there are increases in the levels of phosphatidylcholine and phosphatidylinositol in the central brains of the zinc‐deficient flies compared to the control flies. In contrast, the abundance of phosphatidylethanolamine in the brains of the zinc‐deficient flies is lower. These data are consistent with that of cognitive‐diminishing drugs, thus providing insight into the biological and molecular effects of zinc deficiency on the major brain lipids and opening a new treatment target for cognitive deficit in zinc deficiency." @default.
• W3024291246 created "2020-05-21" @default.
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• W3024291246 date "2020-06-16" @default.
• W3024291246 modified "2023-10-17" @default.
• W3024291246 title "Zinc Deficiency Leads to Lipid Changes in <i>Drosophila</i> Brain Similar to Cognitive‐Impairing Drugs: An Imaging Mass Spectrometry Study" @default.
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• W3024291246 doi "https://doi.org/10.1002/cbic.202000197" @default.
• W3024291246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7586942" @default.
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