FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024349936> ?p ?o ?g. }

• W3024349936 endingPage "669" @default.
• W3024349936 startingPage "668" @default.
• W3024349936 abstract "Objectives Bacterial vaginosis (BV) is a common gynecologic complaint, prone to recurrence, with limited therapeutic options. The purpose of this study is to identify bacterial or host drivers of BV recurrences. Methods A prospective study of women with BV is ongoing, utilizing a multi-‘omic approach to characterize the vaginal mucosal system. BV is diagnosed based on Amsel criteria and Nugent scoring at recruitment, with BV+ participants receiving treatment. Extensive sampling, including cervical biopsies, is clinically performed at 0, 1, and 6 months, and participants self-collect vaginal swabs (daily) and rectal swabs (monthly) for 6 months. Collected specimens are analyzed using multiparameter flow cytometry, microbiologic culture, 16S rRNA sequencing, metaproteomics, metagenomics and metabolomics. Monthly questionnaires are collected detailing diet, vaginal hygiene and sexual practices. Results We have currently enrolled 37 participants (9 completed: 3 BV+, 6 BV-). Preliminary analysis demonstrates 83% of BV- participants had a Lactobacillus dominant profile (n=6). Two BV+ participants had polymicrobial profiles and one was Gardnerella dominant (n=3). Flow cytometry analysis identified significant decreases in T cell subsets (p=0.008) including CD8+ (p=0.03) and CD4-CD8- (p=0.021) T cells in the genital tract of BV+ participants. We have 84% participant retention and 83% average daily swabs collected per month, with no serious adverse effects and few women declining biopsies. Conclusions We have established a prospective cohort to characterize the daily temporal dynamics of the vaginal microbiome in BV recurrence with high resolution. This study will be used to identify drivers of recurrent BV which are putative targets for novel, long-lasting therapeutic interventions. Bacterial vaginosis (BV) is a common gynecologic complaint, prone to recurrence, with limited therapeutic options. The purpose of this study is to identify bacterial or host drivers of BV recurrences. A prospective study of women with BV is ongoing, utilizing a multi-‘omic approach to characterize the vaginal mucosal system. BV is diagnosed based on Amsel criteria and Nugent scoring at recruitment, with BV+ participants receiving treatment. Extensive sampling, including cervical biopsies, is clinically performed at 0, 1, and 6 months, and participants self-collect vaginal swabs (daily) and rectal swabs (monthly) for 6 months. Collected specimens are analyzed using multiparameter flow cytometry, microbiologic culture, 16S rRNA sequencing, metaproteomics, metagenomics and metabolomics. Monthly questionnaires are collected detailing diet, vaginal hygiene and sexual practices. We have currently enrolled 37 participants (9 completed: 3 BV+, 6 BV-). Preliminary analysis demonstrates 83% of BV- participants had a Lactobacillus dominant profile (n=6). Two BV+ participants had polymicrobial profiles and one was Gardnerella dominant (n=3). Flow cytometry analysis identified significant decreases in T cell subsets (p=0.008) including CD8+ (p=0.03) and CD4-CD8- (p=0.021) T cells in the genital tract of BV+ participants. We have 84% participant retention and 83% average daily swabs collected per month, with no serious adverse effects and few women declining biopsies. We have established a prospective cohort to characterize the daily temporal dynamics of the vaginal microbiome in BV recurrence with high resolution. This study will be used to identify drivers of recurrent BV which are putative targets for novel, long-lasting therapeutic interventions." @default.
• W3024349936 created "2020-05-21" @default.
• W3024349936 creator A5002745056 @default.
• W3024349936 creator A5021152308 @default.
• W3024349936 creator A5029710988 @default.
• W3024349936 creator A5032528802 @default.
• W3024349936 creator A5034768962 @default.
• W3024349936 creator A5041637515 @default.
• W3024349936 creator A5046533739 @default.
• W3024349936 creator A5057849776 @default.
• W3024349936 creator A5061940690 @default.
• W3024349936 creator A5064670418 @default.
• W3024349936 creator A5065996656 @default.
• W3024349936 creator A5081455970 @default.
• W3024349936 creator A5087936830 @default.
• W3024349936 creator A5089011345 @default.
• W3024349936 date "2020-05-01" @default.
• W3024349936 modified "2023-09-26" @default.
• W3024349936 title "The study of host-bacterial relationships and immune function in different vaginal environments (THRIVE Study)" @default.
• W3024349936 doi "https://doi.org/10.1016/j.jogc.2020.02.023" @default.
• W3024349936 hasPublicationYear "2020" @default.
• W3024349936 type Work @default.
• W3024349936 sameAs 3024349936 @default.
• W3024349936 citedByCount "0" @default.
• W3024349936 crossrefType "journal-article" @default.
• W3024349936 hasAuthorship W3024349936A5002745056 @default.
• W3024349936 hasAuthorship W3024349936A5021152308 @default.
• W3024349936 hasAuthorship W3024349936A5029710988 @default.
• W3024349936 hasAuthorship W3024349936A5032528802 @default.
• W3024349936 hasAuthorship W3024349936A5034768962 @default.
• W3024349936 hasAuthorship W3024349936A5041637515 @default.
• W3024349936 hasAuthorship W3024349936A5046533739 @default.
• W3024349936 hasAuthorship W3024349936A5057849776 @default.
• W3024349936 hasAuthorship W3024349936A5061940690 @default.
• W3024349936 hasAuthorship W3024349936A5064670418 @default.
• W3024349936 hasAuthorship W3024349936A5065996656 @default.
• W3024349936 hasAuthorship W3024349936A5081455970 @default.
• W3024349936 hasAuthorship W3024349936A5087936830 @default.
• W3024349936 hasAuthorship W3024349936A5089011345 @default.
• W3024349936 hasConcept C126322002 @default.
• W3024349936 hasConcept C131872663 @default.
• W3024349936 hasConcept C141071460 @default.
• W3024349936 hasConcept C188816634 @default.
• W3024349936 hasConcept C203014093 @default.
• W3024349936 hasConcept C2777744392 @default.
• W3024349936 hasConcept C2779952448 @default.
• W3024349936 hasConcept C71924100 @default.
• W3024349936 hasConceptScore W3024349936C126322002 @default.
• W3024349936 hasConceptScore W3024349936C131872663 @default.
• W3024349936 hasConceptScore W3024349936C141071460 @default.
• W3024349936 hasConceptScore W3024349936C188816634 @default.
• W3024349936 hasConceptScore W3024349936C203014093 @default.
• W3024349936 hasConceptScore W3024349936C2777744392 @default.
• W3024349936 hasConceptScore W3024349936C2779952448 @default.
• W3024349936 hasConceptScore W3024349936C71924100 @default.
• W3024349936 hasIssue "5" @default.
• W3024349936 hasLocation W30243499361 @default.
• W3024349936 hasOpenAccess W3024349936 @default.
• W3024349936 hasPrimaryLocation W30243499361 @default.
• W3024349936 hasRelatedWork W2082781313 @default.
• W3024349936 hasRelatedWork W2332163804 @default.
• W3024349936 hasRelatedWork W2399257041 @default.
• W3024349936 hasRelatedWork W2771049038 @default.
• W3024349936 hasRelatedWork W2905589283 @default.
• W3024349936 hasRelatedWork W2992166816 @default.
• W3024349936 hasRelatedWork W3084218073 @default.
• W3024349936 hasRelatedWork W62818913 @default.
• W3024349936 hasRelatedWork W2191193874 @default.
• W3024349936 hasRelatedWork W2624757132 @default.
• W3024349936 hasVolume "42" @default.
• W3024349936 isParatext "false" @default.
• W3024349936 isRetracted "false" @default.
• W3024349936 magId "3024349936" @default.
• W3024349936 workType "article" @default.