Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024357966> ?p ?o ?g. }
- W3024357966 abstract "Abstract Arthritogenic alphaviruses such as Chikungunya virus and O’nyong nyong virus cause acute and chronic crippling arthralgia associated with inflammatory immune responses. However, the physiological functions of individual immune signaling pathways in the pathogenesis of alphaviral arthritis remain poorly understood. Here we report that a deficiency in the stimulator-of-interferon-genes (STING) led to enhanced viral loads, exacerbated inflammation and selectively elevated expression of CXCL10, a chemoattractant for monocytes/macrophages/T cells, in mouse feet. Cxcl10 -/- mice had the same viremia as wild-type animals, but fewer immune infiltrates and lower viral loads in footpads at the peak of arthritic disease (6-8 days post infection). Macrophages constituted the largest immune cell population in footpads following infection, which were significantly reduced in Cxcl10 -/- mice. The viral RNA loads in neutrophils and macrophages were reduced in Cxcl10 -/- compared to wild-type mice. In summary, our results demonstrate that STING signaling represses, while CXCL10 signaling promotes, pathogenesis of alphaviral disease." @default.
- W3024357966 created "2020-05-21" @default.
- W3024357966 creator A5000422885 @default.
- W3024357966 creator A5016253930 @default.
- W3024357966 creator A5022173812 @default.
- W3024357966 creator A5027034727 @default.
- W3024357966 creator A5036251125 @default.
- W3024357966 creator A5045018810 @default.
- W3024357966 creator A5066389905 @default.
- W3024357966 date "2020-05-15" @default.
- W3024357966 modified "2023-09-27" @default.
- W3024357966 title "STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses" @default.
- W3024357966 cites W1517210971 @default.
- W3024357966 cites W1668099561 @default.
- W3024357966 cites W1968178474 @default.
- W3024357966 cites W1979537768 @default.
- W3024357966 cites W1992012316 @default.
- W3024357966 cites W1993712001 @default.
- W3024357966 cites W2000037127 @default.
- W3024357966 cites W2004476696 @default.
- W3024357966 cites W2009336118 @default.
- W3024357966 cites W2013486491 @default.
- W3024357966 cites W2014429324 @default.
- W3024357966 cites W2016131266 @default.
- W3024357966 cites W2028357619 @default.
- W3024357966 cites W2031182394 @default.
- W3024357966 cites W2041345682 @default.
- W3024357966 cites W2059964907 @default.
- W3024357966 cites W2060004514 @default.
- W3024357966 cites W2060917702 @default.
- W3024357966 cites W2063353079 @default.
- W3024357966 cites W2068012691 @default.
- W3024357966 cites W2070324879 @default.
- W3024357966 cites W2070608209 @default.
- W3024357966 cites W2072756799 @default.
- W3024357966 cites W2098128683 @default.
- W3024357966 cites W2099610218 @default.
- W3024357966 cites W2103230759 @default.
- W3024357966 cites W2103496411 @default.
- W3024357966 cites W2119791199 @default.
- W3024357966 cites W2122249084 @default.
- W3024357966 cites W2124770252 @default.
- W3024357966 cites W2127568306 @default.
- W3024357966 cites W2129071472 @default.
- W3024357966 cites W2134552328 @default.
- W3024357966 cites W2136631930 @default.
- W3024357966 cites W2138880157 @default.
- W3024357966 cites W2141231462 @default.
- W3024357966 cites W2145610587 @default.
- W3024357966 cites W2152347367 @default.
- W3024357966 cites W2154171253 @default.
- W3024357966 cites W2157068697 @default.
- W3024357966 cites W2157428298 @default.
- W3024357966 cites W2157730228 @default.
- W3024357966 cites W2158156866 @default.
- W3024357966 cites W2158631358 @default.
- W3024357966 cites W2159133324 @default.
- W3024357966 cites W2165748936 @default.
- W3024357966 cites W2167519482 @default.
- W3024357966 cites W2204988760 @default.
- W3024357966 cites W2259698181 @default.
- W3024357966 cites W2395491666 @default.
- W3024357966 cites W2406941593 @default.
- W3024357966 cites W2509957385 @default.
- W3024357966 cites W2525729338 @default.
- W3024357966 cites W2554163879 @default.
- W3024357966 cites W2583116097 @default.
- W3024357966 cites W2594220414 @default.
- W3024357966 cites W2792824713 @default.
- W3024357966 cites W2800014486 @default.
- W3024357966 doi "https://doi.org/10.1101/2020.05.13.095083" @default.
- W3024357966 hasPublicationYear "2020" @default.
- W3024357966 type Work @default.
- W3024357966 sameAs 3024357966 @default.
- W3024357966 citedByCount "1" @default.
- W3024357966 countsByYear W30243579662023 @default.
- W3024357966 crossrefType "posted-content" @default.
- W3024357966 hasAuthorship W3024357966A5000422885 @default.
- W3024357966 hasAuthorship W3024357966A5016253930 @default.
- W3024357966 hasAuthorship W3024357966A5022173812 @default.
- W3024357966 hasAuthorship W3024357966A5027034727 @default.
- W3024357966 hasAuthorship W3024357966A5036251125 @default.
- W3024357966 hasAuthorship W3024357966A5045018810 @default.
- W3024357966 hasAuthorship W3024357966A5066389905 @default.
- W3024357966 hasBestOaLocation W30243579661 @default.
- W3024357966 hasConcept C13373296 @default.
- W3024357966 hasConcept C159047783 @default.
- W3024357966 hasConcept C203014093 @default.
- W3024357966 hasConcept C2522874641 @default.
- W3024357966 hasConcept C2776914184 @default.
- W3024357966 hasConcept C2777077863 @default.
- W3024357966 hasConcept C2780942790 @default.
- W3024357966 hasConcept C5858377 @default.
- W3024357966 hasConcept C86803240 @default.
- W3024357966 hasConcept C8891405 @default.
- W3024357966 hasConceptScore W3024357966C13373296 @default.
- W3024357966 hasConceptScore W3024357966C159047783 @default.
- W3024357966 hasConceptScore W3024357966C203014093 @default.
- W3024357966 hasConceptScore W3024357966C2522874641 @default.
- W3024357966 hasConceptScore W3024357966C2776914184 @default.