Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024362502> ?p ?o ?g. }
- W3024362502 abstract "Optical microscopy has a diffraction limited resolution of about 250 nm. Fluorescence methods (e.g. PALM, STORM, STED) beat this, but they are still limited to 10 s of nm, and the images are an indirect pointillist representation of only part of the original object. Here we describe a way of combining a sample preparation technique taken from histopathology, with a probe-based nano-imaging technique, (s SNOM) from the world of Solid State Physics. This allows us to image subcellular structures optically, and at a nanoscale resolution that is about 100 x better than normal microscopes. By adding a tuneable laser source, we also demonstrate mid-infrared chemical nano-imaging (MICHNI) in human myeloma cells and we use it to map the binding sites of the anti cancer drug bortezomib to less than 10 zL sized intracellular components. MICHNI is label free and can be used with any biological material and drugs with specific functional chemistry. We believe that its combination of speed, cheapness, simplicity, safety and chemical contrast promises a transformative impact across the life sciences." @default.
- W3024362502 created "2020-05-21" @default.
- W3024362502 creator A5008875061 @default.
- W3024362502 creator A5025848156 @default.
- W3024362502 creator A5032669228 @default.
- W3024362502 creator A5034697409 @default.
- W3024362502 creator A5036857412 @default.
- W3024362502 creator A5054775841 @default.
- W3024362502 creator A5057927631 @default.
- W3024362502 creator A5063387417 @default.
- W3024362502 creator A5069007121 @default.
- W3024362502 creator A5084623947 @default.
- W3024362502 date "2020-05-11" @default.
- W3024362502 modified "2023-09-27" @default.
- W3024362502 title "Label-Free Chemical Nano-Imaging of Intracellular Drug Binding Sites" @default.
- W3024362502 cites W1503393361 @default.
- W3024362502 cites W1626513324 @default.
- W3024362502 cites W1963630834 @default.
- W3024362502 cites W1965238080 @default.
- W3024362502 cites W1966629264 @default.
- W3024362502 cites W1977303037 @default.
- W3024362502 cites W1991424734 @default.
- W3024362502 cites W2009783036 @default.
- W3024362502 cites W2011055829 @default.
- W3024362502 cites W2025068736 @default.
- W3024362502 cites W2037714083 @default.
- W3024362502 cites W2070218019 @default.
- W3024362502 cites W2073831114 @default.
- W3024362502 cites W2079762296 @default.
- W3024362502 cites W2103782445 @default.
- W3024362502 cites W2128677827 @default.
- W3024362502 cites W2147368157 @default.
- W3024362502 cites W2175781977 @default.
- W3024362502 cites W2181484581 @default.
- W3024362502 cites W2264080087 @default.
- W3024362502 cites W2509303103 @default.
- W3024362502 cites W2577934610 @default.
- W3024362502 cites W2775471907 @default.
- W3024362502 cites W2785399043 @default.
- W3024362502 cites W2884055185 @default.
- W3024362502 cites W2950224362 @default.
- W3024362502 cites W811696649 @default.
- W3024362502 cites W1481377485 @default.
- W3024362502 hasPublicationYear "2020" @default.
- W3024362502 type Work @default.
- W3024362502 sameAs 3024362502 @default.
- W3024362502 citedByCount "0" @default.
- W3024362502 crossrefType "posted-content" @default.
- W3024362502 hasAuthorship W3024362502A5008875061 @default.
- W3024362502 hasAuthorship W3024362502A5025848156 @default.
- W3024362502 hasAuthorship W3024362502A5032669228 @default.
- W3024362502 hasAuthorship W3024362502A5034697409 @default.
- W3024362502 hasAuthorship W3024362502A5036857412 @default.
- W3024362502 hasAuthorship W3024362502A5054775841 @default.
- W3024362502 hasAuthorship W3024362502A5057927631 @default.
- W3024362502 hasAuthorship W3024362502A5063387417 @default.
- W3024362502 hasAuthorship W3024362502A5069007121 @default.
- W3024362502 hasAuthorship W3024362502A5084623947 @default.
- W3024362502 hasConcept C105780059 @default.
- W3024362502 hasConcept C120665830 @default.
- W3024362502 hasConcept C121332964 @default.
- W3024362502 hasConcept C12554922 @default.
- W3024362502 hasConcept C147080431 @default.
- W3024362502 hasConcept C171250308 @default.
- W3024362502 hasConcept C185592680 @default.
- W3024362502 hasConcept C192562407 @default.
- W3024362502 hasConcept C30282128 @default.
- W3024362502 hasConcept C45206210 @default.
- W3024362502 hasConcept C520434653 @default.
- W3024362502 hasConcept C86803240 @default.
- W3024362502 hasConceptScore W3024362502C105780059 @default.
- W3024362502 hasConceptScore W3024362502C120665830 @default.
- W3024362502 hasConceptScore W3024362502C121332964 @default.
- W3024362502 hasConceptScore W3024362502C12554922 @default.
- W3024362502 hasConceptScore W3024362502C147080431 @default.
- W3024362502 hasConceptScore W3024362502C171250308 @default.
- W3024362502 hasConceptScore W3024362502C185592680 @default.
- W3024362502 hasConceptScore W3024362502C192562407 @default.
- W3024362502 hasConceptScore W3024362502C30282128 @default.
- W3024362502 hasConceptScore W3024362502C45206210 @default.
- W3024362502 hasConceptScore W3024362502C520434653 @default.
- W3024362502 hasConceptScore W3024362502C86803240 @default.
- W3024362502 hasLocation W30243625021 @default.
- W3024362502 hasOpenAccess W3024362502 @default.
- W3024362502 hasPrimaryLocation W30243625021 @default.
- W3024362502 hasRelatedWork W1481355217 @default.
- W3024362502 hasRelatedWork W1575104981 @default.
- W3024362502 hasRelatedWork W2028979699 @default.
- W3024362502 hasRelatedWork W2044444042 @default.
- W3024362502 hasRelatedWork W2085823300 @default.
- W3024362502 hasRelatedWork W2111410246 @default.
- W3024362502 hasRelatedWork W2275799923 @default.
- W3024362502 hasRelatedWork W2314272864 @default.
- W3024362502 hasRelatedWork W2463053807 @default.
- W3024362502 hasRelatedWork W2528534568 @default.
- W3024362502 hasRelatedWork W2622322819 @default.
- W3024362502 hasRelatedWork W2805834819 @default.
- W3024362502 hasRelatedWork W2890857119 @default.
- W3024362502 hasRelatedWork W2955895355 @default.
- W3024362502 hasRelatedWork W2970286108 @default.