Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024422206> ?p ?o ?g. }
- W3024422206 abstract "Summary With sequencing as a standard frontline protocol to identify emerging viruses such zika virus and SARS-CoV2, direct utilization of sequence data to program antivirals against the viruses could accelerate drug development to treat their infections. CRISPR-Cas effectors are promising candidates that could be programmed to inactivate viral genetic material based on sequence data but several challenges such as delivery and design of effective crRNA need to be addressed to realize practical use. Here, we showed that virus-like particle (VLP) could deliver PspCas13b-crRNA ribonucleoprotein (RNP) in nanomolar range to efficiently suppress dengue virus infection in primary human target cells. Shortening spacer length could significantly enhance RNA-targeting efficiency of PspCas13b in mammalian cells compared to the natural length of 30 nucleotides without compromising multiplex targeting by a crRNA array. Our results demonstrate the potentials of applying PspCas13b RNP to suppress RNA virus infection, with implications in targeting host RNA as well." @default.
- W3024422206 created "2020-05-21" @default.
- W3024422206 creator A5000188720 @default.
- W3024422206 creator A5007292179 @default.
- W3024422206 creator A5013757503 @default.
- W3024422206 creator A5019961862 @default.
- W3024422206 creator A5021029087 @default.
- W3024422206 creator A5023990066 @default.
- W3024422206 creator A5024578752 @default.
- W3024422206 creator A5033668385 @default.
- W3024422206 creator A5049179921 @default.
- W3024422206 creator A5051497042 @default.
- W3024422206 creator A5055181867 @default.
- W3024422206 creator A5076827700 @default.
- W3024422206 creator A5082987869 @default.
- W3024422206 date "2020-05-17" @default.
- W3024422206 modified "2023-10-17" @default.
- W3024422206 title "Potent programmable antiviral against dengue virus in primary human cells by Cas13b RNP with short spacer and delivery by virus-like particle" @default.
- W3024422206 cites W1998770647 @default.
- W3024422206 cites W2033573754 @default.
- W3024422206 cites W2040944858 @default.
- W3024422206 cites W2092706417 @default.
- W3024422206 cites W2099973274 @default.
- W3024422206 cites W2115235864 @default.
- W3024422206 cites W2119292034 @default.
- W3024422206 cites W2133396499 @default.
- W3024422206 cites W2134717733 @default.
- W3024422206 cites W2138015041 @default.
- W3024422206 cites W2170531749 @default.
- W3024422206 cites W2170725518 @default.
- W3024422206 cites W2562947047 @default.
- W3024422206 cites W2567995016 @default.
- W3024422206 cites W2763042654 @default.
- W3024422206 cites W2765284830 @default.
- W3024422206 cites W2765351619 @default.
- W3024422206 cites W2774806607 @default.
- W3024422206 cites W2785904295 @default.
- W3024422206 cites W2792432150 @default.
- W3024422206 cites W2793349369 @default.
- W3024422206 cites W2793359586 @default.
- W3024422206 cites W2793366365 @default.
- W3024422206 cites W2795477566 @default.
- W3024422206 cites W2883728704 @default.
- W3024422206 cites W2904133612 @default.
- W3024422206 cites W2922315004 @default.
- W3024422206 cites W2922387607 @default.
- W3024422206 cites W2949383259 @default.
- W3024422206 cites W2979487934 @default.
- W3024422206 cites W2990436921 @default.
- W3024422206 cites W3010962106 @default.
- W3024422206 cites W3011119456 @default.
- W3024422206 doi "https://doi.org/10.1101/2020.05.17.100388" @default.
- W3024422206 hasPublicationYear "2020" @default.
- W3024422206 type Work @default.
- W3024422206 sameAs 3024422206 @default.
- W3024422206 citedByCount "0" @default.
- W3024422206 crossrefType "posted-content" @default.
- W3024422206 hasAuthorship W3024422206A5000188720 @default.
- W3024422206 hasAuthorship W3024422206A5007292179 @default.
- W3024422206 hasAuthorship W3024422206A5013757503 @default.
- W3024422206 hasAuthorship W3024422206A5019961862 @default.
- W3024422206 hasAuthorship W3024422206A5021029087 @default.
- W3024422206 hasAuthorship W3024422206A5023990066 @default.
- W3024422206 hasAuthorship W3024422206A5024578752 @default.
- W3024422206 hasAuthorship W3024422206A5033668385 @default.
- W3024422206 hasAuthorship W3024422206A5049179921 @default.
- W3024422206 hasAuthorship W3024422206A5051497042 @default.
- W3024422206 hasAuthorship W3024422206A5055181867 @default.
- W3024422206 hasAuthorship W3024422206A5076827700 @default.
- W3024422206 hasAuthorship W3024422206A5082987869 @default.
- W3024422206 hasBestOaLocation W30244222061 @default.
- W3024422206 hasConcept C104317684 @default.
- W3024422206 hasConcept C144501496 @default.
- W3024422206 hasConcept C159047783 @default.
- W3024422206 hasConcept C2522874641 @default.
- W3024422206 hasConcept C2779635636 @default.
- W3024422206 hasConcept C2781188995 @default.
- W3024422206 hasConcept C51785407 @default.
- W3024422206 hasConcept C533803919 @default.
- W3024422206 hasConcept C54355233 @default.
- W3024422206 hasConcept C67705224 @default.
- W3024422206 hasConcept C70721500 @default.
- W3024422206 hasConcept C75934600 @default.
- W3024422206 hasConcept C84356384 @default.
- W3024422206 hasConcept C86803240 @default.
- W3024422206 hasConcept C95444343 @default.
- W3024422206 hasConcept C98108389 @default.
- W3024422206 hasConceptScore W3024422206C104317684 @default.
- W3024422206 hasConceptScore W3024422206C144501496 @default.
- W3024422206 hasConceptScore W3024422206C159047783 @default.
- W3024422206 hasConceptScore W3024422206C2522874641 @default.
- W3024422206 hasConceptScore W3024422206C2779635636 @default.
- W3024422206 hasConceptScore W3024422206C2781188995 @default.
- W3024422206 hasConceptScore W3024422206C51785407 @default.
- W3024422206 hasConceptScore W3024422206C533803919 @default.
- W3024422206 hasConceptScore W3024422206C54355233 @default.
- W3024422206 hasConceptScore W3024422206C67705224 @default.
- W3024422206 hasConceptScore W3024422206C70721500 @default.
- W3024422206 hasConceptScore W3024422206C75934600 @default.
- W3024422206 hasConceptScore W3024422206C84356384 @default.