FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024429795> ?p ?o ?g. }

• W3024429795 endingPage "3523" @default.
• W3024429795 startingPage "3523" @default.
• W3024429795 abstract "Increasing evidence suggests that intestinal dysfunctions may represent early events in Alzheimer’s disease and contribute to brain pathology. This study examined the relationship between onset of cognitive impairment and colonic dysfunctions in a spontaneous AD model before the full development of brain pathology. SAMP8 mice underwent Morris water maze and assessment of faecal output at four, six and eight months of age. In vitro colonic motility was examined. Faecal and colonic Aβ, tau proteins, α-synuclein and IL-1β were assessed by ELISA. Colonic citrate synthase activity was assessed by spectrophotometry. Colonic NLRP3, caspase-1 and ASC expression were evaluated by Western blotting. Colonic eosinophil density and claudin-1 expression were evaluated by immunohistochemistry. The effect of Aβ on NLRP3 signalling and mitochondrial function was tested in cultured cells. Cognitive impairment and decreased faecal output occurred in SAMP8 mice from six months. When compared with SAMR1, SAMP8 animals displayed: (1) impaired in vitro colonic contractions; (2) increased enteric AD-related proteins, IL-1β, active-caspase-1 expression and eosinophil density; and (3) decreased citrate synthase activity and claudin-1 expression. In THP-1 cells, Aβ promoted IL-1β release, which was abrogated upon incubation with caspase-1 inhibitor or in ASC-/- cells. Aβ decreased mitochondrial function in THP-1 cells. In SAMP8, enteric AD-related proteins deposition, inflammation and impaired colonic excitatory neurotransmission, occurring before the full brain pathology development, could contribute to bowel dysmotility and represent prodromal events in AD." @default.
• W3024429795 created "2020-05-21" @default.
• W3024429795 creator A5001776302 @default.
• W3024429795 creator A5008782167 @default.
• W3024429795 creator A5016094054 @default.
• W3024429795 creator A5018622363 @default.
• W3024429795 creator A5019271987 @default.
• W3024429795 creator A5020949961 @default.
• W3024429795 creator A5025506804 @default.
• W3024429795 creator A5033637579 @default.
• W3024429795 creator A5035777809 @default.
• W3024429795 creator A5042677537 @default.
• W3024429795 creator A5042707107 @default.
• W3024429795 creator A5048310750 @default.
• W3024429795 creator A5049744281 @default.
• W3024429795 creator A5059071069 @default.
• W3024429795 creator A5063075289 @default.
• W3024429795 creator A5067062942 @default.
• W3024429795 creator A5067808979 @default.
• W3024429795 creator A5068616704 @default.
• W3024429795 creator A5071495918 @default.
• W3024429795 creator A5076742551 @default.
• W3024429795 creator A5085102363 @default.
• W3024429795 creator A5087674626 @default.
• W3024429795 date "2020-05-15" @default.
• W3024429795 modified "2023-10-18" @default.
• W3024429795 title "Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition" @default.
• W3024429795 cites W1590784339 @default.
• W3024429795 cites W1964732491 @default.
• W3024429795 cites W1965229261 @default.
• W3024429795 cites W1970152641 @default.
• W3024429795 cites W1975049648 @default.
• W3024429795 cites W1990782273 @default.
• W3024429795 cites W1992152055 @default.
• W3024429795 cites W2000134546 @default.
• W3024429795 cites W2008132152 @default.
• W3024429795 cites W2011353487 @default.
• W3024429795 cites W2013168381 @default.
• W3024429795 cites W2018304868 @default.
• W3024429795 cites W2031967942 @default.
• W3024429795 cites W2035594496 @default.
• W3024429795 cites W2045044466 @default.
• W3024429795 cites W2064243975 @default.
• W3024429795 cites W2067811915 @default.
• W3024429795 cites W2071415161 @default.
• W3024429795 cites W2072010946 @default.
• W3024429795 cites W2088038548 @default.
• W3024429795 cites W2088897584 @default.
• W3024429795 cites W2094227464 @default.
• W3024429795 cites W2113719626 @default.
• W3024429795 cites W2122564376 @default.
• W3024429795 cites W2133574882 @default.
• W3024429795 cites W2135510357 @default.
• W3024429795 cites W2149614271 @default.
• W3024429795 cites W2159247740 @default.
• W3024429795 cites W2162158185 @default.
• W3024429795 cites W2169305550 @default.
• W3024429795 cites W2172204522 @default.
• W3024429795 cites W2186115486 @default.
• W3024429795 cites W2213478767 @default.
• W3024429795 cites W2273923068 @default.
• W3024429795 cites W2415734071 @default.
• W3024429795 cites W2507288765 @default.
• W3024429795 cites W2510560444 @default.
• W3024429795 cites W2519408637 @default.
• W3024429795 cites W2566271081 @default.
• W3024429795 cites W2581756184 @default.
• W3024429795 cites W2582624056 @default.
• W3024429795 cites W2587539025 @default.
• W3024429795 cites W2596770143 @default.
• W3024429795 cites W2600656194 @default.
• W3024429795 cites W2606673671 @default.
• W3024429795 cites W2609809651 @default.
• W3024429795 cites W2747545266 @default.
• W3024429795 cites W2761210275 @default.
• W3024429795 cites W2767005092 @default.
• W3024429795 cites W2774851697 @default.
• W3024429795 cites W2775218043 @default.
• W3024429795 cites W2777928756 @default.
• W3024429795 cites W2788825976 @default.
• W3024429795 cites W2793910911 @default.
• W3024429795 cites W2803442844 @default.
• W3024429795 cites W2806197765 @default.
• W3024429795 cites W2886878642 @default.
• W3024429795 cites W2889267256 @default.
• W3024429795 cites W2890743650 @default.
• W3024429795 cites W2902195261 @default.
• W3024429795 cites W2905177566 @default.
• W3024429795 cites W2923380089 @default.
• W3024429795 cites W2948844134 @default.
• W3024429795 cites W2951544248 @default.
• W3024429795 cites W2952857785 @default.
• W3024429795 cites W4211213171 @default.
• W3024429795 cites W48640801 @default.
• W3024429795 doi "https://doi.org/10.3390/ijms21103523" @default.
• W3024429795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7278916" @default.
• W3024429795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32429301" @default.
• W3024429795 hasPublicationYear "2020" @default.

• next