Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024481108> ?p ?o ?g. }
- W3024481108 endingPage "1244" @default.
- W3024481108 startingPage "1244" @default.
- W3024481108 abstract "Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb) that is restricted to the forebrain to rule out any systemic effects of Asm overexpression on depressive-like symptoms. The increase in Asm activity was higher in male Asm-tgfb mice than in female Asm-tgfb mice due to the breeding strategy, which allows for the generation of wild-type littermates as appropriate controls. Asm overexpression in the forebrain of male mice resulted in a depressive-like phenotype, whereas in female mice, Asm overexpression resulted in a social anxiogenic-like phenotype. Ceramides in male Asm-tgfb mice were elevated specifically in the dorsal hippocampus. mRNA expression analyses indicated that the increase in Asm activity affected other ceramide-generating pathways, which might help to balance ceramide levels in cortical brain regions. This forebrain-specific mouse model offers a novel tool for dissecting the molecular mechanisms that play a role in the pathophysiology of major depression." @default.
- W3024481108 created "2020-05-21" @default.
- W3024481108 creator A5033938485 @default.
- W3024481108 creator A5036892744 @default.
- W3024481108 creator A5041073789 @default.
- W3024481108 creator A5042391881 @default.
- W3024481108 creator A5048830214 @default.
- W3024481108 creator A5049016107 @default.
- W3024481108 creator A5055903757 @default.
- W3024481108 creator A5067913949 @default.
- W3024481108 date "2020-05-18" @default.
- W3024481108 modified "2023-09-29" @default.
- W3024481108 title "The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice" @default.
- W3024481108 cites W1499087703 @default.
- W3024481108 cites W1931677656 @default.
- W3024481108 cites W1967786563 @default.
- W3024481108 cites W1969307681 @default.
- W3024481108 cites W1991899733 @default.
- W3024481108 cites W2000404485 @default.
- W3024481108 cites W2000673878 @default.
- W3024481108 cites W2002311959 @default.
- W3024481108 cites W2004684279 @default.
- W3024481108 cites W2008619709 @default.
- W3024481108 cites W2019782049 @default.
- W3024481108 cites W2030438495 @default.
- W3024481108 cites W2038891352 @default.
- W3024481108 cites W2044733292 @default.
- W3024481108 cites W2050590069 @default.
- W3024481108 cites W2085246663 @default.
- W3024481108 cites W2093475197 @default.
- W3024481108 cites W2114570899 @default.
- W3024481108 cites W2129579709 @default.
- W3024481108 cites W2162423225 @default.
- W3024481108 cites W2164766370 @default.
- W3024481108 cites W2276595824 @default.
- W3024481108 cites W2496213445 @default.
- W3024481108 cites W2511946169 @default.
- W3024481108 cites W2516638500 @default.
- W3024481108 cites W2551695323 @default.
- W3024481108 cites W2562140849 @default.
- W3024481108 cites W2563089309 @default.
- W3024481108 cites W2602355755 @default.
- W3024481108 cites W2751484595 @default.
- W3024481108 cites W2759564445 @default.
- W3024481108 cites W2882987804 @default.
- W3024481108 cites W2885260563 @default.
- W3024481108 cites W2897833019 @default.
- W3024481108 cites W2935562069 @default.
- W3024481108 cites W2941721545 @default.
- W3024481108 cites W2995868466 @default.
- W3024481108 doi "https://doi.org/10.3390/cells9051244" @default.
- W3024481108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7290754" @default.
- W3024481108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32443534" @default.
- W3024481108 hasPublicationYear "2020" @default.
- W3024481108 type Work @default.
- W3024481108 sameAs 3024481108 @default.
- W3024481108 citedByCount "11" @default.
- W3024481108 countsByYear W30244811082020 @default.
- W3024481108 countsByYear W30244811082021 @default.
- W3024481108 countsByYear W30244811082022 @default.
- W3024481108 countsByYear W30244811082023 @default.
- W3024481108 crossrefType "journal-article" @default.
- W3024481108 hasAuthorship W3024481108A5033938485 @default.
- W3024481108 hasAuthorship W3024481108A5036892744 @default.
- W3024481108 hasAuthorship W3024481108A5041073789 @default.
- W3024481108 hasAuthorship W3024481108A5042391881 @default.
- W3024481108 hasAuthorship W3024481108A5048830214 @default.
- W3024481108 hasAuthorship W3024481108A5049016107 @default.
- W3024481108 hasAuthorship W3024481108A5055903757 @default.
- W3024481108 hasAuthorship W3024481108A5067913949 @default.
- W3024481108 hasBestOaLocation W30244811081 @default.
- W3024481108 hasConcept C10162356 @default.
- W3024481108 hasConcept C104317684 @default.
- W3024481108 hasConcept C126322002 @default.
- W3024481108 hasConcept C127716648 @default.
- W3024481108 hasConcept C134018914 @default.
- W3024481108 hasConcept C190283241 @default.
- W3024481108 hasConcept C2777851122 @default.
- W3024481108 hasConcept C2778163477 @default.
- W3024481108 hasConcept C2779715522 @default.
- W3024481108 hasConcept C2781161787 @default.
- W3024481108 hasConcept C2781457462 @default.
- W3024481108 hasConcept C529278444 @default.
- W3024481108 hasConcept C55493867 @default.
- W3024481108 hasConcept C61322309 @default.
- W3024481108 hasConcept C71924100 @default.
- W3024481108 hasConcept C86803240 @default.
- W3024481108 hasConcept C95444343 @default.
- W3024481108 hasConceptScore W3024481108C10162356 @default.
- W3024481108 hasConceptScore W3024481108C104317684 @default.
- W3024481108 hasConceptScore W3024481108C126322002 @default.
- W3024481108 hasConceptScore W3024481108C127716648 @default.
- W3024481108 hasConceptScore W3024481108C134018914 @default.
- W3024481108 hasConceptScore W3024481108C190283241 @default.
- W3024481108 hasConceptScore W3024481108C2777851122 @default.
- W3024481108 hasConceptScore W3024481108C2778163477 @default.
- W3024481108 hasConceptScore W3024481108C2779715522 @default.
- W3024481108 hasConceptScore W3024481108C2781161787 @default.