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• W3024492044 abstract "The chemical investigation of Anonidium mannii root extract by column chromatography techniques led to the isolation of eight compounds among which two previously unreported compounds; a lanostane-type triterpene, lanosta-7,9(11),23-triene-3β,15α-diol 1 and an alkaloid, 9-hydroxy-8-methoxyphenanthridin-6(5H)-one 2 along with six known compounds: lanosta-7,9(11),24-triene-3β,21-diol 3, oxoanolobine 4, 3, 4-dihydroxybenzoic acid 5, stigmasterol 6, β-sitosterol 7 and 3-O-β-D-glucopyranosyl-β-stigmasterol 8. Their structures were established from spectral data, mainly HR-ESIMS, 1 D and 2 D NMR and by comparison with literature data. The crude root and stem bark extracts (AMR and AMB) and the isolated compounds (1–8) were tested against nine Gram-negative bacteria using rapid p-iodonitrotetrazolium chloride ≥97% (INT) microdilution technique. It was found that AMR, AMB and compound 5 were active against the nine tested bacteria with MIC values ranging from 64 to 1024 µg/mL. Compounds 1–4 had selective antibacterial activities whilst 6–8 were not active." @default.
• W3024492044 created "2020-05-21" @default.
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• W3024492044 date "2020-05-13" @default.
• W3024492044 modified "2023-09-27" @default.
• W3024492044 title "A phenanthridin-6(<i>5H</i>)-one derivative and a lanostane-type triterpene with antibacterial properties from <i>Anonidium mannii</i> (Oliv). Engl. & Diels (Annonaceae)" @default.
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• W3024492044 doi "https://doi.org/10.1080/14786419.2020.1758094" @default.
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