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• W3024495124 abstract "We previously reported on the monobody E1, which specifically targets the tumor marker hEphA2. In this study, we labeled NOTA-conjugated E1 with 64Cu (64Cu-NOTA-E1) and evaluated biologic characteristics. The uptake of 64Cu-NOTA-E1 in PC3 cells (a human prostate cancer cell line) with high expression of hEphA2 increased in a time-dependent manner. In PC3 xenograft mice, 64Cu-NOTA-E1 injected via the tail vein allowed visualization of tumors on positron emission tomography after 1 h and the highest uptake measured at 24 h post-injection. By contrast, the radioactivity of other tissues either did not increase or decreased over 24 h. This indicates that 64Cu-NOTA-E1 has high tumor uptake and retention, with rapid clearance, and low background values in other tissues. Therefore, 64Cu-NOTA-E1 should be suitable as a novel PET imaging agent for hEphA2-expressing tumors." @default.
• W3024495124 created "2020-05-21" @default.
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• W3024495124 date "2020-07-01" @default.
• W3024495124 modified "2023-10-17" @default.
• W3024495124 title "Production of 64Cu-labeled monobody for imaging of human EphA2-expressing tumors" @default.
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• W3024495124 doi "https://doi.org/10.1016/j.bmcl.2020.127262" @default.
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