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- W3024542008 abstract "Abstract Proliferative kidney disease (PKD), caused by the myxozoan Tetracapsuloides bryosalmonae, is one of the most serious parasitic diseases of salmonids in which outbreaks cause severe economic constraints for the aquaculture industry and declines of wild species throughout Europe and North America. Given that rainbow trout ( Oncorhynchus mykiss ) is one of the most widely farmed freshwater fish and an important model species for fish immunology, most of the knowledge on how the fish immune response is affected during PKD is from this organism. Once rainbow trout are infected, PKD pathogenesis results in a chronic kidney immunopathology mediated by decreasing myeloid cells and increasing lymphocytes. Transcriptional studies have revealed the regulation of essential genes related to T‐helper (Th)‐like functions and a dysregulated B‐cell antibody type response. Recent reports have discovered unique details of teleost B‐cell differentiation and functionality and characterized the differential immunoglobulin (Ig)‐mediated response. These studies have solidified the rainbow trout T. bryosalmonae system as a sophisticated disease model capable of feeding key advances into mainstream immunology and have contributed essential information to design novel parasite disease prevention strategies. In our following perspective, we summarize these efforts to evaluate the immune mechanisms of rainbow trout during PKD pathogenesis." @default.
- W3024542008 created "2020-05-21" @default.
- W3024542008 creator A5003853028 @default.
- W3024542008 creator A5022938406 @default.
- W3024542008 creator A5038092036 @default.
- W3024542008 creator A5050002981 @default.
- W3024542008 date "2020-05-31" @default.
- W3024542008 modified "2023-10-04" @default.
- W3024542008 title "A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout" @default.
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