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- W3024557065 abstract "Azurophilic granulation of blasts is a feature of acute myeloid leukemia (AML). Granular acute lymphoblastic leukemia (ALL) may mimic AML due to the presence of cytoplasmic granules in lymphoblasts, but cytochemistry and immunophenotyping are helpful in making the correct diagnosis. Toluidine blue (TB) is a metachromatic dye, which stains basophils and myeloid blasts that exhibit basophilic differentiation. Reactivity for TB has not been described in lymphoblasts. We herein report two cases of granular ALL with blasts exhibiting reactivity for TB that caused diagnostic dilemma. Immunophenotyping and cytogenetic studies were helpful in making a correct diagnosis. This report of two rare case highlight the reactivity of lymphoblasts with TB not hitherto described and the importance of a detailed diagnostic work-up in acute leukemia. Blastların azurofilik granülasyonu, akut miyeloid löseminin (AML) bir özelliğidir. Granüler akut lenfoblastik lösemi (ALL), sitoplazmik granüllerin lenfoblastlardaki varlığına bağlı olarak AML’ye benzeyebilir, ancak histokimya ve immünofenotipleme doğru tanının konulmasında yardımcıdır. Toluidin mavisi (TB) bir metakromatik boya olup, bazofilik diferansiyasyon sergileyen bazofiller ve miyeloid blastları boyar. TB'ye yönelik reaktivite, lenfoblastlarda tanımlanmamıştır. Bu yayında, tanı ikilemine neden olan TB’ye yönelik reaktivite sergileyen blastlar ile granüler ALL’ye yönelik iki vaka rapor edilmektedir. İmmünofenotipleme ve sitogenetik çalışmalar, doğru tanının konulmasını sağlamıştır. Bu iki nadir vaka raporu ile şimdiye dek tanımlanmamış TB’li lenfoblastların reaktivitesinin ve akut lösemide ayrıntılı tanısal tetkikin öneminin altı çizilmektedir." @default.
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- W3024557065 date "2010-03-05" @default.
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- W3024557065 title "Unusual cytochemical reactivity for toluidine blue in granular acute lymphoblastic leukemia: a report of two rare cases." @default.
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