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- W3024560077 abstract "Importance of sperm-derived transcripts and chromatin imprints in organismal development is poorly investigated. Here using an integrative approach, we show that human sperm transcripts are equally important as oocyte. Sperm-specific and sperm-oocyte common transcripts carry distinct chromatin structures at their promoters correlating with corresponding transcript levels in sperm. Interestingly, sperm-specific H3K4me3 patterns at the lincRNA promoters are not maintained in the germ layers and somatic tissues. However, bivalent chromatin at the sperm-specific protein-coding gene promoters is maintained throughout the development. Sperm-specific transcripts reach their peak expression during zygotic genome activation, whereas sperm-oocyte common transcripts are present during early preimplantation development but decline at the onset of zygotic genome activation. Additionally, there is an inverse correlation between sperm-specific and sperm-oocyte lincRNAs throughout the development. Sperm-lincRNAs also show aberrant activation in tumors. Overall, our observations indicate that sperm transcripts carrying chromatin imprints may play an important role in human development and cancer." @default.
- W3024560077 created "2020-05-21" @default.
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- W3024560077 date "2020-06-01" @default.
- W3024560077 modified "2023-09-27" @default.
- W3024560077 title "Sperm Originated Chromatin Imprints and LincRNAs in Organismal Development and Cancer" @default.
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- W3024560077 doi "https://doi.org/10.1016/j.isci.2020.101165" @default.
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