Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024562190> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3024562190 abstract "The protein Atg2 has been proposed to form a membrane tether that mediates lipid transfer from the ER to the phagophore in autophagy. However, recent kinetic measurements on the human homolog ATG2A indicated a transport rate of only about one lipid per minute, which would be far too slow to deliver the millions of lipids required to form a phagophore on a physiological time scale. Here, we revisit the analysis of the fluorescence quenching experiments. We develop a detailed kinetic model of the lipid transfer between two membranes bridged by a tether that forms a conduit for lipids. The model provides an excellent fit to the fluorescence experiments, with a lipid transfer rate of about 100 per second and protein. At this rate, Atg2-mediated transfer can supply a significant fraction of the lipids required in autophagosome biogenesis. Our kinetic model is generally applicable to lipid-transfer experiments, in particular to proteins forming organelle contact sites in cells." @default.
- W3024562190 created "2020-05-21" @default.
- W3024562190 creator A5016674669 @default.
- W3024562190 creator A5059945365 @default.
- W3024562190 date "2020-05-14" @default.
- W3024562190 modified "2023-09-27" @default.
- W3024562190 title "Kinetics of Atg2-mediated lipid transfer from the ER can account for phagophore expansion" @default.
- W3024562190 cites W1988568995 @default.
- W3024562190 cites W2031272029 @default.
- W3024562190 cites W2050917405 @default.
- W3024562190 cites W2089780431 @default.
- W3024562190 cites W2091907000 @default.
- W3024562190 cites W2093722962 @default.
- W3024562190 cites W2144892927 @default.
- W3024562190 cites W2164233810 @default.
- W3024562190 cites W2233665003 @default.
- W3024562190 cites W2777157902 @default.
- W3024562190 cites W2809349355 @default.
- W3024562190 cites W2885454574 @default.
- W3024562190 cites W2885910759 @default.
- W3024562190 cites W2890848016 @default.
- W3024562190 cites W2923461283 @default.
- W3024562190 cites W2935116054 @default.
- W3024562190 cites W2956011757 @default.
- W3024562190 cites W2977360258 @default.
- W3024562190 cites W2984469096 @default.
- W3024562190 cites W3100993956 @default.
- W3024562190 doi "https://doi.org/10.1101/2020.05.12.090977" @default.
- W3024562190 hasPublicationYear "2020" @default.
- W3024562190 type Work @default.
- W3024562190 sameAs 3024562190 @default.
- W3024562190 citedByCount "11" @default.
- W3024562190 countsByYear W30245621902020 @default.
- W3024562190 countsByYear W30245621902021 @default.
- W3024562190 countsByYear W30245621902022 @default.
- W3024562190 countsByYear W30245621902023 @default.
- W3024562190 crossrefType "posted-content" @default.
- W3024562190 hasAuthorship W3024562190A5016674669 @default.
- W3024562190 hasAuthorship W3024562190A5059945365 @default.
- W3024562190 hasBestOaLocation W30245621901 @default.
- W3024562190 hasConcept C104317684 @default.
- W3024562190 hasConcept C121332964 @default.
- W3024562190 hasConcept C121745418 @default.
- W3024562190 hasConcept C12554922 @default.
- W3024562190 hasConcept C131934819 @default.
- W3024562190 hasConcept C148898269 @default.
- W3024562190 hasConcept C168240541 @default.
- W3024562190 hasConcept C168296220 @default.
- W3024562190 hasConcept C181199279 @default.
- W3024562190 hasConcept C185592680 @default.
- W3024562190 hasConcept C190283241 @default.
- W3024562190 hasConcept C203522944 @default.
- W3024562190 hasConcept C25095133 @default.
- W3024562190 hasConcept C41625074 @default.
- W3024562190 hasConcept C55493867 @default.
- W3024562190 hasConcept C62520636 @default.
- W3024562190 hasConcept C7251936 @default.
- W3024562190 hasConcept C86803240 @default.
- W3024562190 hasConcept C91881484 @default.
- W3024562190 hasConcept C95444343 @default.
- W3024562190 hasConcept C98539663 @default.
- W3024562190 hasConceptScore W3024562190C104317684 @default.
- W3024562190 hasConceptScore W3024562190C121332964 @default.
- W3024562190 hasConceptScore W3024562190C121745418 @default.
- W3024562190 hasConceptScore W3024562190C12554922 @default.
- W3024562190 hasConceptScore W3024562190C131934819 @default.
- W3024562190 hasConceptScore W3024562190C148898269 @default.
- W3024562190 hasConceptScore W3024562190C168240541 @default.
- W3024562190 hasConceptScore W3024562190C168296220 @default.
- W3024562190 hasConceptScore W3024562190C181199279 @default.
- W3024562190 hasConceptScore W3024562190C185592680 @default.
- W3024562190 hasConceptScore W3024562190C190283241 @default.
- W3024562190 hasConceptScore W3024562190C203522944 @default.
- W3024562190 hasConceptScore W3024562190C25095133 @default.
- W3024562190 hasConceptScore W3024562190C41625074 @default.
- W3024562190 hasConceptScore W3024562190C55493867 @default.
- W3024562190 hasConceptScore W3024562190C62520636 @default.
- W3024562190 hasConceptScore W3024562190C7251936 @default.
- W3024562190 hasConceptScore W3024562190C86803240 @default.
- W3024562190 hasConceptScore W3024562190C91881484 @default.
- W3024562190 hasConceptScore W3024562190C95444343 @default.
- W3024562190 hasConceptScore W3024562190C98539663 @default.
- W3024562190 hasLocation W30245621901 @default.
- W3024562190 hasLocation W30245621902 @default.
- W3024562190 hasOpenAccess W3024562190 @default.
- W3024562190 hasPrimaryLocation W30245621901 @default.
- W3024562190 hasRelatedWork W2022884184 @default.
- W3024562190 hasRelatedWork W2056478340 @default.
- W3024562190 hasRelatedWork W2064042544 @default.
- W3024562190 hasRelatedWork W2071153190 @default.
- W3024562190 hasRelatedWork W2081962941 @default.
- W3024562190 hasRelatedWork W2319007238 @default.
- W3024562190 hasRelatedWork W2475772472 @default.
- W3024562190 hasRelatedWork W2957721022 @default.
- W3024562190 hasRelatedWork W3019335729 @default.
- W3024562190 hasRelatedWork W642194586 @default.
- W3024562190 isParatext "false" @default.
- W3024562190 isRetracted "false" @default.
- W3024562190 magId "3024562190" @default.
- W3024562190 workType "article" @default.