Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024640476> ?p ?o ?g. }
- W3024640476 endingPage "107638" @default.
- W3024640476 startingPage "107638" @default.
- W3024640476 abstract "The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we report de novo actin polymerization after cellular entry around the bacterium-containing vacuole (BCV) leading to the formation of a dynamic actin cocoon. This cocoon is thicker than any described cellular actin structure and functions as a gatekeeper for the cytosolic access of the pathogen. Host CDC42, TOCA-1, N-WASP, WIP, the Arp2/3 complex, cortactin, coronin, and cofilin are recruited to the actin cocoon. They are subverted by T3SS effectors, such as IpgD, IpgB1, and IcsB. IcsB immobilizes components of the actin polymerization machinery at the BCV dependent on its fatty acyltransferase activity. This represents a unique microbial subversion strategy through localized entrapment of host actin regulators causing massive actin assembly. We propose that the cocoon promotes subsequent invasion steps for successful Shigella infection." @default.
- W3024640476 created "2020-05-21" @default.
- W3024640476 creator A5020473340 @default.
- W3024640476 creator A5027674094 @default.
- W3024640476 creator A5040837216 @default.
- W3024640476 creator A5045786088 @default.
- W3024640476 creator A5053283412 @default.
- W3024640476 creator A5057615478 @default.
- W3024640476 creator A5058956974 @default.
- W3024640476 creator A5061724902 @default.
- W3024640476 date "2020-05-01" @default.
- W3024640476 modified "2023-10-13" @default.
- W3024640476 title "Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection" @default.
- W3024640476 cites W1562501682 @default.
- W3024640476 cites W1602426796 @default.
- W3024640476 cites W1603724904 @default.
- W3024640476 cites W1790987188 @default.
- W3024640476 cites W1947325587 @default.
- W3024640476 cites W1973434033 @default.
- W3024640476 cites W1974767973 @default.
- W3024640476 cites W1978751572 @default.
- W3024640476 cites W1984387240 @default.
- W3024640476 cites W1985860758 @default.
- W3024640476 cites W1988796273 @default.
- W3024640476 cites W1991340429 @default.
- W3024640476 cites W2008132225 @default.
- W3024640476 cites W2012890157 @default.
- W3024640476 cites W2019730901 @default.
- W3024640476 cites W2019731805 @default.
- W3024640476 cites W2023822923 @default.
- W3024640476 cites W2023994136 @default.
- W3024640476 cites W2034167623 @default.
- W3024640476 cites W2036654148 @default.
- W3024640476 cites W2036923984 @default.
- W3024640476 cites W2040010587 @default.
- W3024640476 cites W2052080816 @default.
- W3024640476 cites W2054883747 @default.
- W3024640476 cites W2055376777 @default.
- W3024640476 cites W2062359771 @default.
- W3024640476 cites W2069738597 @default.
- W3024640476 cites W2085244040 @default.
- W3024640476 cites W2086505124 @default.
- W3024640476 cites W2089327289 @default.
- W3024640476 cites W2091425339 @default.
- W3024640476 cites W2092986430 @default.
- W3024640476 cites W2099573412 @default.
- W3024640476 cites W2101413510 @default.
- W3024640476 cites W2103783368 @default.
- W3024640476 cites W2104475366 @default.
- W3024640476 cites W2105809801 @default.
- W3024640476 cites W2107625881 @default.
- W3024640476 cites W2110640625 @default.
- W3024640476 cites W2112048948 @default.
- W3024640476 cites W2112659088 @default.
- W3024640476 cites W2114801075 @default.
- W3024640476 cites W2118875203 @default.
- W3024640476 cites W2122782850 @default.
- W3024640476 cites W2124232374 @default.
- W3024640476 cites W2128368215 @default.
- W3024640476 cites W2135342003 @default.
- W3024640476 cites W2139027064 @default.
- W3024640476 cites W2148334175 @default.
- W3024640476 cites W2151889957 @default.
- W3024640476 cites W2152511989 @default.
- W3024640476 cites W2156571424 @default.
- W3024640476 cites W2161925614 @default.
- W3024640476 cites W2164390539 @default.
- W3024640476 cites W2170543527 @default.
- W3024640476 cites W2170644493 @default.
- W3024640476 cites W2170671189 @default.
- W3024640476 cites W2170996392 @default.
- W3024640476 cites W2202855866 @default.
- W3024640476 cites W2233798213 @default.
- W3024640476 cites W2267790100 @default.
- W3024640476 cites W2319486227 @default.
- W3024640476 cites W2406638036 @default.
- W3024640476 cites W2415172195 @default.
- W3024640476 cites W2615883512 @default.
- W3024640476 cites W2756038181 @default.
- W3024640476 cites W2763785504 @default.
- W3024640476 cites W2764157960 @default.
- W3024640476 cites W2790673148 @default.
- W3024640476 cites W2883006823 @default.
- W3024640476 cites W2935110817 @default.
- W3024640476 cites W3011036988 @default.
- W3024640476 cites W4214499815 @default.
- W3024640476 cites W51164494 @default.
- W3024640476 doi "https://doi.org/10.1016/j.celrep.2020.107638" @default.
- W3024640476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7225751" @default.
- W3024640476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32402280" @default.
- W3024640476 hasPublicationYear "2020" @default.
- W3024640476 type Work @default.
- W3024640476 sameAs 3024640476 @default.
- W3024640476 citedByCount "26" @default.
- W3024640476 countsByYear W30246404762020 @default.
- W3024640476 countsByYear W30246404762021 @default.
- W3024640476 countsByYear W30246404762022 @default.
- W3024640476 countsByYear W30246404762023 @default.