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• W3024650495 endingPage "194577" @default.
• W3024650495 startingPage "194577" @default.
• W3024650495 abstract "Transcription factors of the BLIMP1/PRDM1 family are important regulators of development. BLIMP1/PRDM1 can both activate and repress gene expression, however, the mechanism of activation is not well understood. Therefore, we looked for factors involved in gene activation by C. elegans BLMP-1, the ortholog of BLIMP1/PRDM1. BLMP-1 activates the expression of bed-3, a gene involved in vulval development. By screening nuclear proteins that function in vulval development, we identified two proteins (LDB-1 and HAM-3) required for BLMP-1 dependent bed-3 expression. LDB-1 is the sole C. elegans member of the LIM Binding Protein (LDB) family, whereas HAM-3 is an accessory subunit of the SWI/SNF complex (ortholog of human SMARCD3/BAF60C). A core SWI/SNF subunit SWSN-1 (ortholog of human SMARCC1/BAF155) is also involved. We found that LDB-1 and HAM-3 bind to BLMP-1, suggesting that BLMP-1 recruits LDB-1 and the SWI/SNF complex to activate bed-3 expression. Interestingly, LDB-1 and HAM-3 are involved in both transcriptional activation and repression. In particular, BLMP-1, LDB-1 and HAM-3 co-regulate a set of hypodermal genes including bed-3 (activated), col-124 (activated) and lin-29 (repressed). On the other hand, LDB-1 and HAM-3 are not required for activation or repression of some genes regulated by BLMP-1 (e.g. T09D3.8, nas-10). We also found that human LDB1, SMARCD3/BAF60C and SMARCC1/BAF155 all physically interact with human BLIMP1/PRDM1 in vitro and are closely associated with BLIMP1/PRDM1 in vivo. Taken together, these results identify LDB1 and SWI/SNF as likely conserved cofactors of BLIMP1/PRDM1, which participate in activation and repression of a subset of BLIMP1/PRDM1-regulated genes." @default.
• W3024650495 created "2020-05-21" @default.
• W3024650495 creator A5012808854 @default.
• W3024650495 creator A5079388173 @default.
• W3024650495 creator A5080491035 @default.
• W3024650495 date "2020-09-01" @default.
• W3024650495 modified "2023-09-27" @default.
• W3024650495 title "LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1" @default.
• W3024650495 cites W1167831124 @default.
• W3024650495 cites W1521011562 @default.
• W3024650495 cites W1882571075 @default.
• W3024650495 cites W1901834675 @default.
• W3024650495 cites W1921244251 @default.
• W3024650495 cites W1944127002 @default.
• W3024650495 cites W1966601613 @default.
• W3024650495 cites W1969206687 @default.
• W3024650495 cites W1969279502 @default.
• W3024650495 cites W1970831058 @default.
• W3024650495 cites W1970854602 @default.
• W3024650495 cites W1981988708 @default.
• W3024650495 cites W1982128166 @default.
• W3024650495 cites W1986006829 @default.
• W3024650495 cites W1986625228 @default.
• W3024650495 cites W1999185664 @default.
• W3024650495 cites W2000054590 @default.
• W3024650495 cites W2002422619 @default.
• W3024650495 cites W2003991434 @default.
• W3024650495 cites W2004945062 @default.
• W3024650495 cites W2006342636 @default.
• W3024650495 cites W2015584675 @default.
• W3024650495 cites W2016991737 @default.
• W3024650495 cites W2017132951 @default.
• W3024650495 cites W2021179704 @default.
• W3024650495 cites W2029676157 @default.
• W3024650495 cites W2043332368 @default.
• W3024650495 cites W2048726155 @default.
• W3024650495 cites W2053937978 @default.
• W3024650495 cites W2055377404 @default.
• W3024650495 cites W2056616030 @default.
• W3024650495 cites W2065898700 @default.
• W3024650495 cites W2066555099 @default.
• W3024650495 cites W2068319284 @default.
• W3024650495 cites W2073552235 @default.
• W3024650495 cites W2075428268 @default.
• W3024650495 cites W2080278886 @default.
• W3024650495 cites W2081091627 @default.
• W3024650495 cites W2085133317 @default.
• W3024650495 cites W2085928743 @default.
• W3024650495 cites W2091689280 @default.
• W3024650495 cites W2095924801 @default.
• W3024650495 cites W2096489607 @default.
• W3024650495 cites W2098761664 @default.
• W3024650495 cites W2102324931 @default.
• W3024650495 cites W2105058701 @default.
• W3024650495 cites W2105409819 @default.
• W3024650495 cites W2111480476 @default.
• W3024650495 cites W2113729804 @default.
• W3024650495 cites W2113771680 @default.
• W3024650495 cites W2117132491 @default.
• W3024650495 cites W2119079421 @default.
• W3024650495 cites W2119997582 @default.
• W3024650495 cites W2121092400 @default.
• W3024650495 cites W2121195205 @default.
• W3024650495 cites W2122348846 @default.
• W3024650495 cites W2129615909 @default.
• W3024650495 cites W2131606648 @default.
• W3024650495 cites W2133162368 @default.
• W3024650495 cites W2139477475 @default.
• W3024650495 cites W2139728074 @default.
• W3024650495 cites W2141991853 @default.
• W3024650495 cites W2142766411 @default.
• W3024650495 cites W2143377660 @default.
• W3024650495 cites W2144407335 @default.
• W3024650495 cites W2147515706 @default.
• W3024650495 cites W2150407460 @default.
• W3024650495 cites W2152474709 @default.
• W3024650495 cites W2161890613 @default.
• W3024650495 cites W2266921405 @default.
• W3024650495 cites W2301162848 @default.
• W3024650495 cites W2340200299 @default.
• W3024650495 cites W2463821769 @default.
• W3024650495 cites W2584632839 @default.
• W3024650495 cites W2604994143 @default.
• W3024650495 cites W2755141646 @default.
• W3024650495 cites W2758319764 @default.
• W3024650495 cites W2890749536 @default.
• W3024650495 cites W2990887256 @default.
• W3024650495 cites W3145751116 @default.
• W3024650495 cites W751975581 @default.
• W3024650495 doi "https://doi.org/10.1016/j.bbagrm.2020.194577" @default.
• W3024650495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32417234" @default.
• W3024650495 hasPublicationYear "2020" @default.
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