FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024680380> ?p ?o ?g. }

• W3024680380 endingPage "685.e10" @default.
• W3024680380 startingPage "685.e1" @default.
• W3024680380 abstract "The pre-existing tumor-infiltrating T cell landscape in urothelial cell carcinoma of the bladder (UCB) may obtain prognostic significance and guide treatment decisions, particularly regarding immunotherapy. However, the current studies typically lead to inconsistent conclusions due to the extreme heterogeneity of T cells in cancer. Herein, we investigated the heterogeneity, distribution and clinical significance of tumor-infiltrating T cells based on PD-1 expression, their spatial organization, and the balance between subsets in a series of UCB patients. Flow cytometry for PD-1, CD4, and CD8 was performed in 6 UBC patients and 5 healthy donors. A series of 155 UBC patients with tissue slides were stained for triple color immunofluorescence. Stromal and intratumoral regions of the cancer tissue were respectively evaluated. Features derived from triple staining were analyzed for their correlations with clinical characteristics and patient prognosis. Flow cytometric analysis showed PD-1+ T cells were more frequently accumulated at the tumor site than in blood (p < 0.001). The proportion of PD-1+ T cells within CD4+ and/or CD8+ T cells is higher in the intratumoral region, as compared with the stroma by immunofluorescence evaluation (all p < 0.001, n = 155). Moreover, a high proportion of PD-1+ T cells within T cells in the intratumoral region, but not in the stroma, was predictive of a poorer overall survival (p = 0.0075) and recurrence-free survival (p = 0.0062), and was positively associated with aggressive clinical features (all p < 0.05). However, a low CD4/CD8 ratio among the PD-1+ T cells in the tumor stroma, but not in the intratumoral region, was significantly associated with shorter overall survival (p = 0.0164) and recurrence-free survival (p = 0.0016), which emerged as an independent predictor in multivariate analysis for UCB patients. Taken together, our results emphasize that PD-1 expression in T cell subsets, based on their topographic micro-localizations, provides valuable prognostic information for UCB patients." @default.
• W3024680380 created "2020-05-21" @default.
• W3024680380 creator A5003905939 @default.
• W3024680380 creator A5004581155 @default.
• W3024680380 creator A5007132911 @default.
• W3024680380 creator A5012067060 @default.
• W3024680380 creator A5047273213 @default.
• W3024680380 creator A5056168495 @default.
• W3024680380 creator A5061795808 @default.
• W3024680380 creator A5062284808 @default.
• W3024680380 creator A5066844759 @default.
• W3024680380 creator A5079488107 @default.
• W3024680380 creator A5085180521 @default.
• W3024680380 date "2020-08-01" @default.
• W3024680380 modified "2023-10-15" @default.
• W3024680380 title "PD-1 topographically defines distinct T cell subpopulations in urothelial cell carcinoma of the bladder and predicts patient survival" @default.
• W3024680380 cites W1606413143 @default.
• W3024680380 cites W1984650310 @default.
• W3024680380 cites W1990675339 @default.
• W3024680380 cites W2003139849 @default.
• W3024680380 cites W2014411198 @default.
• W3024680380 cites W2020720650 @default.
• W3024680380 cites W2022495797 @default.
• W3024680380 cites W2046731919 @default.
• W3024680380 cites W2073571081 @default.
• W3024680380 cites W2076335749 @default.
• W3024680380 cites W2093773243 @default.
• W3024680380 cites W2101653483 @default.
• W3024680380 cites W2122656254 @default.
• W3024680380 cites W2132561915 @default.
• W3024680380 cites W2136731993 @default.
• W3024680380 cites W2141269240 @default.
• W3024680380 cites W2152206210 @default.
• W3024680380 cites W2281666530 @default.
• W3024680380 cites W2395763454 @default.
• W3024680380 cites W2559804019 @default.
• W3024680380 cites W2566747056 @default.
• W3024680380 cites W2584071843 @default.
• W3024680380 cites W2589298520 @default.
• W3024680380 cites W2616826864 @default.
• W3024680380 cites W2735904407 @default.
• W3024680380 cites W2766546668 @default.
• W3024680380 cites W2777192533 @default.
• W3024680380 cites W2784331139 @default.
• W3024680380 cites W2803448167 @default.
• W3024680380 cites W2804073610 @default.
• W3024680380 cites W2862742070 @default.
• W3024680380 cites W2889646458 @default.
• W3024680380 cites W2897536537 @default.
• W3024680380 cites W2900317915 @default.
• W3024680380 cites W2904713531 @default.
• W3024680380 cites W2914282788 @default.
• W3024680380 cites W3026809871 @default.
• W3024680380 cites W4211053712 @default.
• W3024680380 cites W4211115520 @default.
• W3024680380 doi "https://doi.org/10.1016/j.urolonc.2020.04.009" @default.
• W3024680380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32409198" @default.
• W3024680380 hasPublicationYear "2020" @default.
• W3024680380 type Work @default.
• W3024680380 sameAs 3024680380 @default.
• W3024680380 citedByCount "6" @default.
• W3024680380 countsByYear W30246803802020 @default.
• W3024680380 countsByYear W30246803802021 @default.
• W3024680380 countsByYear W30246803802022 @default.
• W3024680380 crossrefType "journal-article" @default.
• W3024680380 hasAuthorship W3024680380A5003905939 @default.
• W3024680380 hasAuthorship W3024680380A5004581155 @default.
• W3024680380 hasAuthorship W3024680380A5007132911 @default.
• W3024680380 hasAuthorship W3024680380A5012067060 @default.
• W3024680380 hasAuthorship W3024680380A5047273213 @default.
• W3024680380 hasAuthorship W3024680380A5056168495 @default.
• W3024680380 hasAuthorship W3024680380A5061795808 @default.
• W3024680380 hasAuthorship W3024680380A5062284808 @default.
• W3024680380 hasAuthorship W3024680380A5066844759 @default.
• W3024680380 hasAuthorship W3024680380A5079488107 @default.
• W3024680380 hasAuthorship W3024680380A5085180521 @default.
• W3024680380 hasConcept C121608353 @default.
• W3024680380 hasConcept C126322002 @default.
• W3024680380 hasConcept C142724271 @default.
• W3024680380 hasConcept C143998085 @default.
• W3024680380 hasConcept C159654299 @default.
• W3024680380 hasConcept C167672396 @default.
• W3024680380 hasConcept C16930146 @default.
• W3024680380 hasConcept C203014093 @default.
• W3024680380 hasConcept C204232928 @default.
• W3024680380 hasConcept C2776090121 @default.
• W3024680380 hasConcept C2777546739 @default.
• W3024680380 hasConcept C2777701055 @default.
• W3024680380 hasConcept C2778236600 @default.
• W3024680380 hasConcept C2780352672 @default.
• W3024680380 hasConcept C3019882237 @default.
• W3024680380 hasConcept C502942594 @default.
• W3024680380 hasConcept C52124034 @default.
• W3024680380 hasConcept C553184892 @default.
• W3024680380 hasConcept C63363279 @default.
• W3024680380 hasConcept C71924100 @default.
• W3024680380 hasConcept C8891405 @default.
• W3024680380 hasConceptScore W3024680380C121608353 @default.

• next