Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024710588> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3024710588 endingPage "20" @default.
- W3024710588 startingPage "12" @default.
- W3024710588 abstract "Background Headache is a common complaint of emergency department (ED) patients and current treatment varies with significant limitations. Objective Our aim was to evaluate the efficacy and safety of 2.5 mg i.v. haloperidol in the treatment of severe benign headache in the ED. Methods A randomized, double-blind, placebo-controlled trial was performed in the ED of a single high-volume teaching hospital. Convenience sampling identified 287 eligible patients 13 to 55 years old with benign headache. One hundred and eighteen patients were enrolled to receive either 2.5 mg of haloperidol i.v. or placebo. The primary outcome measure was pain reduction at 60 min. Patients were evaluated for adverse events and follow-up was conducted after discharge. QT measurement was performed at baseline and discharge. Results Fifty-eight patients received haloperidol and 60 patients received placebo. Patients in the haloperidol group reported an average 4.77-unit reduction in visual analogue scale score at 60 min compared to a 1.87-unit reduction in the control group. Thirty-four patients (58.6%) in the haloperidol group had complete resolution of their headache. Treatment with rescue ketorolac was required in 78.3% of the control group and 31% of the haloperidol group. Adverse events were uncommon, benign, and easily treated. No patients in the haloperidol group were found to have QT lengthening. Conclusions This study suggests that 2.5 mg i.v. haloperidol is a rapid and effective treatment for acute, severe, benign headache in ED patients aged 18 to 55 years. Further study is warranted to confirm these results in adolescents. Trial Registration ClinicalTrials.gov Identifier NCT02747511." @default.
- W3024710588 created "2020-05-21" @default.
- W3024710588 creator A5014803224 @default.
- W3024710588 creator A5016882761 @default.
- W3024710588 creator A5039710661 @default.
- W3024710588 creator A5077951580 @default.
- W3024710588 date "2020-07-01" @default.
- W3024710588 modified "2023-10-01" @default.
- W3024710588 title "Treatment of Headache in the Emergency Department: Haloperidol in the Acute Setting (THE-HA Study): A Randomized Clinical Trial" @default.
- W3024710588 cites W1835565565 @default.
- W3024710588 cites W1969523037 @default.
- W3024710588 cites W1977599017 @default.
- W3024710588 cites W1981145934 @default.
- W3024710588 cites W1988102338 @default.
- W3024710588 cites W1990223736 @default.
- W3024710588 cites W1990632045 @default.
- W3024710588 cites W1992334099 @default.
- W3024710588 cites W1993055269 @default.
- W3024710588 cites W1993588191 @default.
- W3024710588 cites W2015290306 @default.
- W3024710588 cites W2027476618 @default.
- W3024710588 cites W2028618083 @default.
- W3024710588 cites W2064243181 @default.
- W3024710588 cites W2090815859 @default.
- W3024710588 cites W2133930763 @default.
- W3024710588 cites W2144072224 @default.
- W3024710588 doi "https://doi.org/10.1016/j.jemermed.2020.04.018" @default.
- W3024710588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32402480" @default.
- W3024710588 hasPublicationYear "2020" @default.
- W3024710588 type Work @default.
- W3024710588 sameAs 3024710588 @default.
- W3024710588 citedByCount "3" @default.
- W3024710588 countsByYear W30247105882021 @default.
- W3024710588 crossrefType "journal-article" @default.
- W3024710588 hasAuthorship W3024710588A5014803224 @default.
- W3024710588 hasAuthorship W3024710588A5016882761 @default.
- W3024710588 hasAuthorship W3024710588A5039710661 @default.
- W3024710588 hasAuthorship W3024710588A5077951580 @default.
- W3024710588 hasConcept C118552586 @default.
- W3024710588 hasConcept C126322002 @default.
- W3024710588 hasConcept C141071460 @default.
- W3024710588 hasConcept C14184104 @default.
- W3024710588 hasConcept C142724271 @default.
- W3024710588 hasConcept C168563851 @default.
- W3024710588 hasConcept C197934379 @default.
- W3024710588 hasConcept C204787440 @default.
- W3024710588 hasConcept C27081682 @default.
- W3024710588 hasConcept C2778446825 @default.
- W3024710588 hasConcept C2780724011 @default.
- W3024710588 hasConcept C2780820201 @default.
- W3024710588 hasConcept C2780948584 @default.
- W3024710588 hasConcept C42219234 @default.
- W3024710588 hasConcept C513476851 @default.
- W3024710588 hasConcept C535046627 @default.
- W3024710588 hasConcept C71924100 @default.
- W3024710588 hasConceptScore W3024710588C118552586 @default.
- W3024710588 hasConceptScore W3024710588C126322002 @default.
- W3024710588 hasConceptScore W3024710588C141071460 @default.
- W3024710588 hasConceptScore W3024710588C14184104 @default.
- W3024710588 hasConceptScore W3024710588C142724271 @default.
- W3024710588 hasConceptScore W3024710588C168563851 @default.
- W3024710588 hasConceptScore W3024710588C197934379 @default.
- W3024710588 hasConceptScore W3024710588C204787440 @default.
- W3024710588 hasConceptScore W3024710588C27081682 @default.
- W3024710588 hasConceptScore W3024710588C2778446825 @default.
- W3024710588 hasConceptScore W3024710588C2780724011 @default.
- W3024710588 hasConceptScore W3024710588C2780820201 @default.
- W3024710588 hasConceptScore W3024710588C2780948584 @default.
- W3024710588 hasConceptScore W3024710588C42219234 @default.
- W3024710588 hasConceptScore W3024710588C513476851 @default.
- W3024710588 hasConceptScore W3024710588C535046627 @default.
- W3024710588 hasConceptScore W3024710588C71924100 @default.
- W3024710588 hasIssue "1" @default.
- W3024710588 hasLocation W30247105881 @default.
- W3024710588 hasOpenAccess W3024710588 @default.
- W3024710588 hasPrimaryLocation W30247105881 @default.
- W3024710588 hasRelatedWork W2041321119 @default.
- W3024710588 hasRelatedWork W2064879719 @default.
- W3024710588 hasRelatedWork W2071404978 @default.
- W3024710588 hasRelatedWork W2085830368 @default.
- W3024710588 hasRelatedWork W2091049947 @default.
- W3024710588 hasRelatedWork W2157754720 @default.
- W3024710588 hasRelatedWork W2381401299 @default.
- W3024710588 hasRelatedWork W2432366219 @default.
- W3024710588 hasRelatedWork W2518610092 @default.
- W3024710588 hasRelatedWork W3204965777 @default.
- W3024710588 hasVolume "59" @default.
- W3024710588 isParatext "false" @default.
- W3024710588 isRetracted "false" @default.
- W3024710588 magId "3024710588" @default.
- W3024710588 workType "article" @default.