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• W3024748658 abstract "Glutathione (GSH) biosynthesis is essential for cellular redox homeostasis and antioxidant defense. The rate-limiting step requires glutamate-cysteine ligase (GCL), which is composed of the catalytic (GCLc) and the modulatory (GCLm) subunits. To evaluate the contribution of GCLc to endothelial function we generated an endothelial-specific Gclc haplo-insufficient mouse model (Gclc e/+ mice). In murine lung endothelial cells (MLEC) derived from these mice we observed a 50% reduction in GCLc levels compared to lung fibroblasts from the same mice. MLEC obtained from haplo-insufficient mice showed significant reduction in GSH levels as well as increased basal and stimulated ROS levels, reduced phosphorylation of eNOS (Ser 1177) and increased eNOS S-glutathionylation, compared to MLEC from wild type (WT) mice. Studies in mesenteric arteries demonstrated impaired endothelium-dependent vasodilation in Gclc(e/+) male mice, which was corrected by pre-incubation with GSH-ethyl-ester and BH4. To study the contribution of endothelial GSH synthesis to renal fibrosis we employed the unilateral ureteral obstruction model in WT and Gclc(e/+) mice. We observed that obstructed kidneys from Gclc(e/+) mice exhibited increased deposition of fibrotic markers and reduced Nrf2 levels. We conclude that the preservation of endothelial GSH biosynthesis is not only critical for endothelial function but also in anti-fibrotic responses." @default.
• W3024748658 created "2020-05-21" @default.
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• W3024748658 date "2018-04-01" @default.
• W3024748658 modified "2023-10-16" @default.
• W3024748658 title "Role of glutathione biosynthesis in endothelial dysfunction and fibrosis" @default.
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• W3024748658 doi "https://doi.org/10.1016/j.redox.2017.08.019" @default.
• W3024748658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5596265" @default.
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• W3024748658 hasPublicationYear "2018" @default.
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