FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024751572> ?p ?o ?g. }

• W3024751572 endingPage "531" @default.
• W3024751572 startingPage "525" @default.
• W3024751572 abstract "Soft tissue leiomyosarcoma (STLMS) is a major histological subtype of adult sarcoma. Although the molecular mechanisms ofLMS have been gradually revealed, no valid therapeutic targets have been identified. In this study, we performed a systematic screening to explore relapse-associated genes in STLMS, using data from The Cancer Genome Atlas-Sarcoma (TCGA-SARC). Then, we investigated the functional role of the gene with the best relapse-prediction value in STLMS by both in-vitro and in-vivo studies. Results showed that AMH and PLA2G10 were two genes with area under curve (AUC) values higher than 0.80 in ROC analysis when detecting relapse. Patients in the high AMH or PLA2G10 expression group had significantly worse relapse-free survival (RFS) compared to the respective low expression group. PLA2G10 was highly expressed in STLMS, but not in other sarcoma subtypes. PLA2G10 overexpression promoted SK-LMS-1 cell growth and G1/S transition, while PLA2G10 knockdown slowed the growth and resulted in G1 phase arrest. PLA2G10 overexpression markedly increased the expression of CDK2 and cyclin E1, but did not influence CDK4, CDK6, cyclin D1, CDK1 or cyclin A expression. PLA2G10 overexpression enhanced SK-LMS-1 cell-derived xenograft tumor growth in nude mice, while PLA2G10 inhibition slowed the growth. Mutation of two critical catalyzing amino acid residues (p.H88A and p.D89A) abrogated the capability of PLA2G10 to catalyze the production of arachidonic acid (AA), and also canceled the regulatory effects on cyclin E1 and CDK2 expression, as well as G1/S transition. In conclusion, PLA2G10 was a specific relapse-associated gene in STLMS. It facilitated the cell-cycle progression of STLMS cells at least by elevating the expression of cyclin E1 and CDK2. The hydrolytic activity was crucial for its oncogenic properties." @default.
• W3024751572 created "2020-05-21" @default.
• W3024751572 creator A5003329913 @default.
• W3024751572 creator A5008194834 @default.
• W3024751572 creator A5015586586 @default.
• W3024751572 creator A5016415336 @default.
• W3024751572 creator A5023734392 @default.
• W3024751572 creator A5024859121 @default.
• W3024751572 creator A5045623195 @default.
• W3024751572 creator A5079178927 @default.
• W3024751572 date "2020-06-01" @default.
• W3024751572 modified "2023-10-16" @default.
• W3024751572 title "PLA2G10 facilitates the cell-cycle progression of soft tissue leiomyosarcoma cells at least by elevating cyclin E1/CDK2 expression" @default.
• W3024751572 cites W1773827424 @default.
• W3024751572 cites W1990778395 @default.
• W3024751572 cites W2019055600 @default.
• W3024751572 cites W2039379186 @default.
• W3024751572 cites W2044570626 @default.
• W3024751572 cites W2050199006 @default.
• W3024751572 cites W2115345848 @default.
• W3024751572 cites W2128411785 @default.
• W3024751572 cites W2152064969 @default.
• W3024751572 cites W2196236965 @default.
• W3024751572 cites W2214074259 @default.
• W3024751572 cites W2231819680 @default.
• W3024751572 cites W2291628580 @default.
• W3024751572 cites W2344325779 @default.
• W3024751572 cites W2398380769 @default.
• W3024751572 cites W2608662477 @default.
• W3024751572 cites W2747674030 @default.
• W3024751572 cites W2765468373 @default.
• W3024751572 cites W2775816941 @default.
• W3024751572 cites W2789664731 @default.
• W3024751572 cites W2991116586 @default.
• W3024751572 cites W2998834744 @default.
• W3024751572 cites W4244844690 @default.
• W3024751572 cites W4285097283 @default.
• W3024751572 cites W4376848385 @default.
• W3024751572 doi "https://doi.org/10.1016/j.bbrc.2020.04.043" @default.
• W3024751572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32423798" @default.
• W3024751572 hasPublicationYear "2020" @default.
• W3024751572 type Work @default.
• W3024751572 sameAs 3024751572 @default.
• W3024751572 citedByCount "11" @default.
• W3024751572 countsByYear W30247515722021 @default.
• W3024751572 countsByYear W30247515722022 @default.
• W3024751572 countsByYear W30247515722023 @default.
• W3024751572 crossrefType "journal-article" @default.
• W3024751572 hasAuthorship W3024751572A5003329913 @default.
• W3024751572 hasAuthorship W3024751572A5008194834 @default.
• W3024751572 hasAuthorship W3024751572A5015586586 @default.
• W3024751572 hasAuthorship W3024751572A5016415336 @default.
• W3024751572 hasAuthorship W3024751572A5023734392 @default.
• W3024751572 hasAuthorship W3024751572A5024859121 @default.
• W3024751572 hasAuthorship W3024751572A5045623195 @default.
• W3024751572 hasAuthorship W3024751572A5079178927 @default.
• W3024751572 hasConcept C104317684 @default.
• W3024751572 hasConcept C120504264 @default.
• W3024751572 hasConcept C121608353 @default.
• W3024751572 hasConcept C142724271 @default.
• W3024751572 hasConcept C153911025 @default.
• W3024751572 hasConcept C16438837 @default.
• W3024751572 hasConcept C173396325 @default.
• W3024751572 hasConcept C199649820 @default.
• W3024751572 hasConcept C199835354 @default.
• W3024751572 hasConcept C2777532014 @default.
• W3024751572 hasConcept C2778256501 @default.
• W3024751572 hasConcept C2778629024 @default.
• W3024751572 hasConcept C2780360765 @default.
• W3024751572 hasConcept C29537977 @default.
• W3024751572 hasConcept C502942594 @default.
• W3024751572 hasConcept C54355233 @default.
• W3024751572 hasConcept C62112901 @default.
• W3024751572 hasConcept C71924100 @default.
• W3024751572 hasConcept C82495950 @default.
• W3024751572 hasConcept C86803240 @default.
• W3024751572 hasConcept C94561458 @default.
• W3024751572 hasConceptScore W3024751572C104317684 @default.
• W3024751572 hasConceptScore W3024751572C120504264 @default.
• W3024751572 hasConceptScore W3024751572C121608353 @default.
• W3024751572 hasConceptScore W3024751572C142724271 @default.
• W3024751572 hasConceptScore W3024751572C153911025 @default.
• W3024751572 hasConceptScore W3024751572C16438837 @default.
• W3024751572 hasConceptScore W3024751572C173396325 @default.
• W3024751572 hasConceptScore W3024751572C199649820 @default.
• W3024751572 hasConceptScore W3024751572C199835354 @default.
• W3024751572 hasConceptScore W3024751572C2777532014 @default.
• W3024751572 hasConceptScore W3024751572C2778256501 @default.
• W3024751572 hasConceptScore W3024751572C2778629024 @default.
• W3024751572 hasConceptScore W3024751572C2780360765 @default.
• W3024751572 hasConceptScore W3024751572C29537977 @default.
• W3024751572 hasConceptScore W3024751572C502942594 @default.
• W3024751572 hasConceptScore W3024751572C54355233 @default.
• W3024751572 hasConceptScore W3024751572C62112901 @default.
• W3024751572 hasConceptScore W3024751572C71924100 @default.
• W3024751572 hasConceptScore W3024751572C82495950 @default.
• W3024751572 hasConceptScore W3024751572C86803240 @default.
• W3024751572 hasConceptScore W3024751572C94561458 @default.

• next