Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024753721> ?p ?o ?g. }
- W3024753721 abstract "Abstract Background Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With advancing survival rates, there is an emergent cohort of UGI and HPB cancer survivors with physical and nutritional deficits, resultant from both the cancer and its treatments. Therefore, rehabilitation to counteract these impairments is required to maximise health related quality of life (HRQOL) in survivorship. The initial feasibility of a multidisciplinary rehabilitation programme for UGI survivors was established in the Rehabilitation Strategies following Oesophago-gastric Cancer (ReStOre) feasibility study and pilot randomised controlled trial (RCT). ReStOre II will now further investigate the efficacy of that programme as it applies to a wider cohort of UGI and HPB cancer survivors, namely survivors of cancer of the oesophagus, stomach, pancreas, and liver. Methods The ReStOre II RCT will compare a 12-week multidisciplinary rehabilitation programme of supervised and self-managed exercise, dietary counselling, and education to standard survivorship care in a cohort of UGI and HPB cancer survivors who are > 3-months post-oesophagectomy/ gastrectomy/ pancreaticoduodenectomy, or major liver resection. One hundred twenty participants (60 per study arm) will be recruited to establish a mean increase in the primary outcome (cardiorespiratory fitness) of 3.5 ml/min/kg with 90% power, 5% significance allowing for 20% drop out. Study outcomes of physical function, body composition, nutritional status, HRQOL, and fatigue will be measured at baseline (T0), post-intervention (T1), and 3-months follow-up (T2). At 1-year follow-up (T3), HRQOL alone will be measured. The impact of ReStOre II on well-being will be examined qualitatively with focus groups/interviews (T1, T2). Bio-samples will be collected from T0-T2 to establish a national UGI and HPB cancer survivorship biobank. The cost effectiveness of ReStOre II will also be analysed. Discussion This RCT will investigate the efficacy of a 12-week multidisciplinary rehabilitation programme for survivors of UGI and HPB cancer compared to standard survivorship care. If effective, ReStOre II will provide an exemplar model of rehabilitation for UGI and HPB cancer survivors. Trial registration The study is registered with ClinicalTrials.gov , registration number: NCT03958019 , date registered: 21/05/2019" @default.
- W3024753721 created "2020-05-21" @default.
- W3024753721 creator A5013966743 @default.
- W3024753721 creator A5014991644 @default.
- W3024753721 creator A5020355211 @default.
- W3024753721 creator A5023152070 @default.
- W3024753721 creator A5023981476 @default.
- W3024753721 creator A5028927701 @default.
- W3024753721 creator A5033082307 @default.
- W3024753721 creator A5042187551 @default.
- W3024753721 creator A5045881568 @default.
- W3024753721 creator A5047109067 @default.
- W3024753721 creator A5048036790 @default.
- W3024753721 creator A5048491760 @default.
- W3024753721 creator A5051943172 @default.
- W3024753721 creator A5054743296 @default.
- W3024753721 creator A5066966766 @default.
- W3024753721 date "2020-05-13" @default.
- W3024753721 modified "2023-10-16" @default.
- W3024753721 title "Rehabilitation strategies following oesophagogastric and Hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomized controlled trial" @default.
- W3024753721 cites W1240635074 @default.
- W3024753721 cites W1824929487 @default.
- W3024753721 cites W1967172483 @default.
- W3024753721 cites W1971474283 @default.
- W3024753721 cites W1976662048 @default.
- W3024753721 cites W1979290264 @default.
- W3024753721 cites W2003239266 @default.
- W3024753721 cites W2014110715 @default.
- W3024753721 cites W2034557879 @default.
- W3024753721 cites W2038729274 @default.
- W3024753721 cites W2051242541 @default.
- W3024753721 cites W2055306670 @default.
- W3024753721 cites W2055869123 @default.
- W3024753721 cites W2062073413 @default.
- W3024753721 cites W2069618315 @default.
- W3024753721 cites W2076823943 @default.
- W3024753721 cites W2079031597 @default.
- W3024753721 cites W2096657471 @default.
- W3024753721 cites W2098752671 @default.
- W3024753721 cites W2107295307 @default.
- W3024753721 cites W2107982301 @default.
- W3024753721 cites W2112395080 @default.
- W3024753721 cites W2141540356 @default.
- W3024753721 cites W2142559775 @default.
- W3024753721 cites W2159031994 @default.
- W3024753721 cites W2165229942 @default.
- W3024753721 cites W2167571044 @default.
- W3024753721 cites W2296273243 @default.
- W3024753721 cites W2312990713 @default.
- W3024753721 cites W2344394089 @default.
- W3024753721 cites W2505149831 @default.
- W3024753721 cites W2517311944 @default.
- W3024753721 cites W2548315011 @default.
- W3024753721 cites W2548809784 @default.
- W3024753721 cites W2587427527 @default.
- W3024753721 cites W2606975853 @default.
- W3024753721 cites W2613417311 @default.
- W3024753721 cites W2613839772 @default.
- W3024753721 cites W2621287299 @default.
- W3024753721 cites W2735444410 @default.
- W3024753721 cites W2742385777 @default.
- W3024753721 cites W2782723235 @default.
- W3024753721 cites W2783634552 @default.
- W3024753721 cites W2788768006 @default.
- W3024753721 cites W2789116207 @default.
- W3024753721 cites W2803438222 @default.
- W3024753721 cites W2884494494 @default.
- W3024753721 cites W2902219846 @default.
- W3024753721 cites W2961684161 @default.
- W3024753721 cites W2969397942 @default.
- W3024753721 cites W2973951640 @default.
- W3024753721 cites W2981263606 @default.
- W3024753721 cites W3015498897 @default.
- W3024753721 cites W4233097826 @default.
- W3024753721 doi "https://doi.org/10.1186/s12885-020-06889-z" @default.
- W3024753721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7222585" @default.
- W3024753721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32404096" @default.
- W3024753721 hasPublicationYear "2020" @default.
- W3024753721 type Work @default.
- W3024753721 sameAs 3024753721 @default.
- W3024753721 citedByCount "12" @default.
- W3024753721 countsByYear W30247537212020 @default.
- W3024753721 countsByYear W30247537212021 @default.
- W3024753721 countsByYear W30247537212022 @default.
- W3024753721 countsByYear W30247537212023 @default.
- W3024753721 crossrefType "journal-article" @default.
- W3024753721 hasAuthorship W3024753721A5013966743 @default.
- W3024753721 hasAuthorship W3024753721A5014991644 @default.
- W3024753721 hasAuthorship W3024753721A5020355211 @default.
- W3024753721 hasAuthorship W3024753721A5023152070 @default.
- W3024753721 hasAuthorship W3024753721A5023981476 @default.
- W3024753721 hasAuthorship W3024753721A5028927701 @default.
- W3024753721 hasAuthorship W3024753721A5033082307 @default.
- W3024753721 hasAuthorship W3024753721A5042187551 @default.
- W3024753721 hasAuthorship W3024753721A5045881568 @default.
- W3024753721 hasAuthorship W3024753721A5047109067 @default.
- W3024753721 hasAuthorship W3024753721A5048036790 @default.
- W3024753721 hasAuthorship W3024753721A5048491760 @default.
- W3024753721 hasAuthorship W3024753721A5051943172 @default.
- W3024753721 hasAuthorship W3024753721A5054743296 @default.