FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024756465> ?p ?o ?g. }

• W3024756465 endingPage "4270" @default.
• W3024756465 startingPage "4257" @default.
• W3024756465 abstract "MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis.miR-939 expression was determined in PCa tissues and cell lines using reverse transcription-quantitative polymerase chain reaction. Cell Counting Kit-8, colony formation, and flow cytometric assays were used to determine the role of miR-939 in PCa cell proliferation and apoptosis in vitro, whereas a tumor xenograft model was generated to evaluate the effect of miR-939 on tumor growth in vivo. Transwell assays were performed to investigate whether miR-939 affects the migration and invasiveness of PCa cells.miR-939 was found to be downregulated in PCa tissues and cell lines, and this downregulation was significantly correlated with tumor stage and lymphatic metastasis. Patients with PCa exhibiting low miR-939 expression had shorter overall survival than those exhibiting high miR-939 expression. Exogenous miR-939 expression suppressed PCa cell proliferation, colony formation, migration, and invasion in vitro; enhanced apoptosis in vitro; and decreased tumor growth in vivo. Investigation of the underlying molecular mechanisms revealed hepatoma-derived growth factor (HDGF) as a direct target gene of miR-939 in PCa. HDGF was found to be significantly upregulated in PCa tissues, and its expression was inversely correlated with miR-939 expression. HDGF silencing and miR-939 upregulation showed similar effects in PCa. Restored HDGF expression counteracted the tumor-suppressive activity of miR-939 overexpression in PCa cells. Furthermore, ectopic miR-939 expression inhibited the WNT/β-catenin pathway activation in PCa both in vitro and in vivo by downregulating HDGF.miR-939 functions as a tumor suppressor during PCa tumorigenesis by directly targeting HDGF and deactivating the WNT/β-catenin pathway, suggesting the miR-939/HDGF/WNT/β-catenin pathway as an effective target for PCa therapy." @default.
• W3024756465 created "2020-05-21" @default.
• W3024756465 creator A5011090649 @default.
• W3024756465 creator A5017100408 @default.
• W3024756465 creator A5023445411 @default.
• W3024756465 creator A5038857775 @default.
• W3024756465 creator A5049341927 @default.
• W3024756465 creator A5070015357 @default.
• W3024756465 date "2020-05-01" @default.
• W3024756465 modified "2023-09-30" @default.
• W3024756465 title "<p>MicroRNA-939 Directly Targets <em>HDGF</em> to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway</p>" @default.
• W3024756465 cites W144423133 @default.
• W3024756465 cites W1512517646 @default.
• W3024756465 cites W1521698887 @default.
• W3024756465 cites W1531642676 @default.
• W3024756465 cites W1898681077 @default.
• W3024756465 cites W1901170167 @default.
• W3024756465 cites W2007457544 @default.
• W3024756465 cites W2014946489 @default.
• W3024756465 cites W2040491701 @default.
• W3024756465 cites W2042458031 @default.
• W3024756465 cites W2043103956 @default.
• W3024756465 cites W2057638900 @default.
• W3024756465 cites W2086879967 @default.
• W3024756465 cites W2092900662 @default.
• W3024756465 cites W2103151642 @default.
• W3024756465 cites W2112785261 @default.
• W3024756465 cites W2124756133 @default.
• W3024756465 cites W2131081587 @default.
• W3024756465 cites W2143802196 @default.
• W3024756465 cites W2160237840 @default.
• W3024756465 cites W2272984102 @default.
• W3024756465 cites W2511949746 @default.
• W3024756465 cites W2526230243 @default.
• W3024756465 cites W2565005984 @default.
• W3024756465 cites W2582900527 @default.
• W3024756465 cites W2619346486 @default.
• W3024756465 cites W2621170905 @default.
• W3024756465 cites W2748687809 @default.
• W3024756465 cites W2753337590 @default.
• W3024756465 cites W2761096572 @default.
• W3024756465 cites W2761647449 @default.
• W3024756465 cites W2768557421 @default.
• W3024756465 cites W2799910796 @default.
• W3024756465 cites W2808904652 @default.
• W3024756465 cites W2810092823 @default.
• W3024756465 cites W2889646458 @default.
• W3024756465 cites W2903663466 @default.
• W3024756465 cites W2912138638 @default.
• W3024756465 cites W2912949593 @default.
• W3024756465 cites W2914330320 @default.
• W3024756465 cites W2916591247 @default.
• W3024756465 cites W2918673627 @default.
• W3024756465 cites W2928902335 @default.
• W3024756465 cites W2938273513 @default.
• W3024756465 cites W2938938636 @default.
• W3024756465 cites W2946403853 @default.
• W3024756465 cites W2950759272 @default.
• W3024756465 cites W2958925270 @default.
• W3024756465 cites W3024376682 @default.
• W3024756465 cites W343738323 @default.
• W3024756465 doi "https://doi.org/10.2147/ott.s250101" @default.
• W3024756465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7244247" @default.
• W3024756465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32547060" @default.
• W3024756465 hasPublicationYear "2020" @default.
• W3024756465 type Work @default.
• W3024756465 sameAs 3024756465 @default.
• W3024756465 citedByCount "8" @default.
• W3024756465 countsByYear W30247564652020 @default.
• W3024756465 countsByYear W30247564652021 @default.
• W3024756465 countsByYear W30247564652023 @default.
• W3024756465 crossrefType "journal-article" @default.
• W3024756465 hasAuthorship W3024756465A5011090649 @default.
• W3024756465 hasAuthorship W3024756465A5017100408 @default.
• W3024756465 hasAuthorship W3024756465A5023445411 @default.
• W3024756465 hasAuthorship W3024756465A5038857775 @default.
• W3024756465 hasAuthorship W3024756465A5049341927 @default.
• W3024756465 hasAuthorship W3024756465A5070015357 @default.
• W3024756465 hasBestOaLocation W30247564651 @default.
• W3024756465 hasConcept C104317684 @default.
• W3024756465 hasConcept C119056186 @default.
• W3024756465 hasConcept C121608353 @default.
• W3024756465 hasConcept C127561419 @default.
• W3024756465 hasConcept C137620995 @default.
• W3024756465 hasConcept C145059251 @default.
• W3024756465 hasConcept C185592680 @default.
• W3024756465 hasConcept C30145163 @default.
• W3024756465 hasConcept C502942594 @default.
• W3024756465 hasConcept C54355233 @default.
• W3024756465 hasConcept C55493867 @default.
• W3024756465 hasConcept C555283112 @default.
• W3024756465 hasConcept C62112901 @default.
• W3024756465 hasConcept C62478195 @default.
• W3024756465 hasConcept C86803240 @default.
• W3024756465 hasConcept C95444343 @default.
• W3024756465 hasConceptScore W3024756465C104317684 @default.
• W3024756465 hasConceptScore W3024756465C119056186 @default.
• W3024756465 hasConceptScore W3024756465C121608353 @default.

• next