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• W3024776812 abstract "Mallard ducks are a natural host and reservoir of avian Influenza A viruses. While most influenza strains can replicate in mallards, the virus typically does not cause substantial disease in this host. Mallards are often resistant to disease caused by highly pathogenic avian influenza viruses, while the same strains can cause severe infection in humans, chickens and even other species of ducks, resulting in systemic spread of the virus and even death. The differences in influenza detection and antiviral effectors responsible for limiting damage in the mallards are largely unknown. Domestic mallards have an early and robust innate response to infection that seems to limit replication and clear highly pathogenic strains. The regulation and timing of the response to influenza also seems to circumvent damage done by a prolonged or dysregulated immune response. Rapid initiation of innate immune responses depends on viral recognition by pattern recognition receptors (PRRs) expressed in tissues where the virus replicates. RIG-like receptors (RLRs), Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are all important influenza sensors in mammals during infection. Ducks utilize many of the same PRRs to detect influenza, namely RIG-I, TLR7 and TLR3 and their downstream adaptors. Ducks also express many of the same signal transduction proteins including TBK1, TRIF and TRAF3. Some antiviral effectors expressed downstream of these signalling pathways inhibit influenza replication in ducks. In this review, we summarize the recent advances in our understanding of influenza recognition and response through duck PRRs and their adaptors. We compare basal tissue expression and regulation of these signalling components in birds, to better understand what contributes to influenza resistance in the duck." @default.
• W3024776812 created "2020-05-21" @default.
• W3024776812 creator A5012267654 @default.
• W3024776812 creator A5014313084 @default.
• W3024776812 date "2020-05-12" @default.
• W3024776812 modified "2023-10-17" @default.
• W3024776812 title "Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens" @default.
• W3024776812 cites W1106136230 @default.
• W3024776812 cites W1437920260 @default.
• W3024776812 cites W1492542185 @default.
• W3024776812 cites W1562614827 @default.
• W3024776812 cites W1571767222 @default.
• W3024776812 cites W1582095946 @default.
• W3024776812 cites W1847769736 @default.
• W3024776812 cites W1852542211 @default.
• W3024776812 cites W1858483607 @default.
• W3024776812 cites W1902641512 @default.
• W3024776812 cites W1909271167 @default.
• W3024776812 cites W1924109658 @default.
• W3024776812 cites W1963937775 @default.
• W3024776812 cites W1967139098 @default.
• W3024776812 cites W1967310385 @default.
• W3024776812 cites W1967463201 @default.
• W3024776812 cites W1967562647 @default.
• W3024776812 cites W1968178474 @default.
• W3024776812 cites W1969601023 @default.
• W3024776812 cites W1971378778 @default.
• W3024776812 cites W1972776583 @default.
• W3024776812 cites W1973646620 @default.
• W3024776812 cites W1975296966 @default.
• W3024776812 cites W1977853360 @default.
• W3024776812 cites W1978527132 @default.
• W3024776812 cites W1979838502 @default.
• W3024776812 cites W1981294127 @default.
• W3024776812 cites W1982006925 @default.
• W3024776812 cites W1983470819 @default.
• W3024776812 cites W1983959087 @default.
• W3024776812 cites W1991186601 @default.
• W3024776812 cites W1991564270 @default.
• W3024776812 cites W1991607297 @default.
• W3024776812 cites W1992756209 @default.
• W3024776812 cites W1993205112 @default.
• W3024776812 cites W1993728991 @default.
• W3024776812 cites W1994034344 @default.
• W3024776812 cites W1994233288 @default.
• W3024776812 cites W1994391392 @default.
• W3024776812 cites W1994724597 @default.
• W3024776812 cites W1996906360 @default.
• W3024776812 cites W1998657702 @default.
• W3024776812 cites W1999518270 @default.
• W3024776812 cites W2000192473 @default.
• W3024776812 cites W2000997294 @default.
• W3024776812 cites W2001747259 @default.
• W3024776812 cites W2001805584 @default.
• W3024776812 cites W2003630425 @default.
• W3024776812 cites W2003988251 @default.
• W3024776812 cites W2004228984 @default.
• W3024776812 cites W2004322145 @default.
• W3024776812 cites W2004727967 @default.
• W3024776812 cites W2009127910 @default.
• W3024776812 cites W2011935686 @default.
• W3024776812 cites W2012034410 @default.
• W3024776812 cites W2013131699 @default.
• W3024776812 cites W2013168127 @default.
• W3024776812 cites W2013202475 @default.
• W3024776812 cites W2014477302 @default.
• W3024776812 cites W2015321393 @default.
• W3024776812 cites W2015359732 @default.
• W3024776812 cites W2016160459 @default.
• W3024776812 cites W2017504661 @default.
• W3024776812 cites W2017515700 @default.
• W3024776812 cites W2020856519 @default.
• W3024776812 cites W2022754521 @default.
• W3024776812 cites W2026575463 @default.
• W3024776812 cites W2026961565 @default.
• W3024776812 cites W2027565750 @default.
• W3024776812 cites W2029765186 @default.
• W3024776812 cites W2031182394 @default.
• W3024776812 cites W2033474198 @default.
• W3024776812 cites W2034865693 @default.
• W3024776812 cites W2036680174 @default.
• W3024776812 cites W2037502650 @default.
• W3024776812 cites W2037654310 @default.
• W3024776812 cites W2037730374 @default.
• W3024776812 cites W2039598645 @default.
• W3024776812 cites W2042433752 @default.
• W3024776812 cites W2044818544 @default.
• W3024776812 cites W2046056601 @default.
• W3024776812 cites W2047365750 @default.
• W3024776812 cites W2047948762 @default.
• W3024776812 cites W2048415438 @default.
• W3024776812 cites W2048676149 @default.
• W3024776812 cites W2049084522 @default.
• W3024776812 cites W2050052221 @default.
• W3024776812 cites W2051705369 @default.
• W3024776812 cites W2052111111 @default.
• W3024776812 cites W2053476949 @default.
• W3024776812 cites W2055995765 @default.
• W3024776812 cites W2057704272 @default.
• W3024776812 cites W2057964111 @default.

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