Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024798873> ?p ?o ?g. }
- W3024798873 endingPage "6106" @default.
- W3024798873 startingPage "6096" @default.
- W3024798873 abstract "Multitargeted therapy could rectify various oncogenic pathways to block tumorigenesis and progression. The combination of endocrine-, immune-, and chemotherapy might exert a highly synergistic effect against certain tumors. Herein, a series of smart Pt(IV) prodrugs 3–6, named Melatplatin, were rationally designed not only to multitarget DNA, MT1, and estrogen receptor (ER) but also to activate immune response. Melatplatin, conjugating first-line chemotherapeutic Pt drugs with human endogenous melatonin (MT), significantly enhanced drug efficacy especially in ER high-expression (ER+) cells, among which 3 presented the most potent cytotoxicity toward ER+ MCF-7 with nanomolar IC50 values 100-fold lower than cisplatin. Melatplatin could bind well to melatonin receptor (MT1) according to molecular docking. Besides, 3 evidently increased intracellular accumulation and DNA damage, upregulated γH2AX and P53, and silenced NF-κB to induce massive apoptosis. Most strikingly, 3 effectively inhibited tumor growth and attenuated systemic toxicity compared to cisplatin in vivo, promoting lymphocyte proliferation in spleen to achieve immune modulation." @default.
- W3024798873 created "2020-05-21" @default.
- W3024798873 creator A5012907699 @default.
- W3024798873 creator A5012911162 @default.
- W3024798873 creator A5014032736 @default.
- W3024798873 creator A5023826377 @default.
- W3024798873 creator A5039568378 @default.
- W3024798873 creator A5043424443 @default.
- W3024798873 creator A5065660461 @default.
- W3024798873 creator A5075415907 @default.
- W3024798873 creator A5082407945 @default.
- W3024798873 date "2020-05-13" @default.
- W3024798873 modified "2023-10-17" @default.
- W3024798873 title "Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response <i>In Vivo</i>" @default.
- W3024798873 cites W184020152 @default.
- W3024798873 cites W1964053201 @default.
- W3024798873 cites W1969455439 @default.
- W3024798873 cites W1972963371 @default.
- W3024798873 cites W1973352944 @default.
- W3024798873 cites W1973507159 @default.
- W3024798873 cites W1974693247 @default.
- W3024798873 cites W1976385056 @default.
- W3024798873 cites W1983466835 @default.
- W3024798873 cites W1988116079 @default.
- W3024798873 cites W1992187202 @default.
- W3024798873 cites W1993713805 @default.
- W3024798873 cites W1996148507 @default.
- W3024798873 cites W2001746497 @default.
- W3024798873 cites W2009439253 @default.
- W3024798873 cites W2016076302 @default.
- W3024798873 cites W2020939852 @default.
- W3024798873 cites W2021805732 @default.
- W3024798873 cites W2028085265 @default.
- W3024798873 cites W2031921473 @default.
- W3024798873 cites W2035772307 @default.
- W3024798873 cites W2040548599 @default.
- W3024798873 cites W2064488040 @default.
- W3024798873 cites W2066450536 @default.
- W3024798873 cites W2068797007 @default.
- W3024798873 cites W2073131323 @default.
- W3024798873 cites W2076494430 @default.
- W3024798873 cites W2076977446 @default.
- W3024798873 cites W2082451253 @default.
- W3024798873 cites W2085249739 @default.
- W3024798873 cites W2095037236 @default.
- W3024798873 cites W2100375454 @default.
- W3024798873 cites W2104432827 @default.
- W3024798873 cites W2114410648 @default.
- W3024798873 cites W2115218756 @default.
- W3024798873 cites W2116049905 @default.
- W3024798873 cites W2123118068 @default.
- W3024798873 cites W2127465976 @default.
- W3024798873 cites W2130672089 @default.
- W3024798873 cites W2131924401 @default.
- W3024798873 cites W2132171918 @default.
- W3024798873 cites W2145028653 @default.
- W3024798873 cites W2203908584 @default.
- W3024798873 cites W2282989227 @default.
- W3024798873 cites W2306843791 @default.
- W3024798873 cites W2308891651 @default.
- W3024798873 cites W2324279107 @default.
- W3024798873 cites W2509124354 @default.
- W3024798873 cites W2510713027 @default.
- W3024798873 cites W2562961196 @default.
- W3024798873 cites W2584601959 @default.
- W3024798873 cites W2593529968 @default.
- W3024798873 cites W2606778500 @default.
- W3024798873 cites W2739574548 @default.
- W3024798873 cites W2742442805 @default.
- W3024798873 cites W2770500610 @default.
- W3024798873 cites W2775293762 @default.
- W3024798873 cites W2775939749 @default.
- W3024798873 cites W2779160996 @default.
- W3024798873 cites W2779612975 @default.
- W3024798873 cites W2788308360 @default.
- W3024798873 cites W2792097235 @default.
- W3024798873 cites W2799938265 @default.
- W3024798873 cites W2804716737 @default.
- W3024798873 cites W2811294037 @default.
- W3024798873 cites W2890439734 @default.
- W3024798873 cites W2895283280 @default.
- W3024798873 cites W2895447854 @default.
- W3024798873 cites W2900341773 @default.
- W3024798873 cites W2900609106 @default.
- W3024798873 cites W2909828641 @default.
- W3024798873 cites W2914922692 @default.
- W3024798873 cites W2937763513 @default.
- W3024798873 cites W2939213051 @default.
- W3024798873 cites W2940543892 @default.
- W3024798873 cites W2944009466 @default.
- W3024798873 cites W2946241853 @default.
- W3024798873 cites W2953594811 @default.
- W3024798873 cites W2953917877 @default.
- W3024798873 cites W2959506989 @default.
- W3024798873 cites W2965688356 @default.
- W3024798873 cites W4211005384 @default.
- W3024798873 cites W4230494879 @default.
- W3024798873 doi "https://doi.org/10.1021/acs.jmedchem.0c00343" @default.