FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024812093> ?p ?o ?g. }

• W3024812093 endingPage "1650" @default.
• W3024812093 startingPage "1643" @default.
• W3024812093 abstract "Traumatic brain injury (TBI) is a devastating actuality in clinics worldwide. It is estimated that approximately 10 million people among the world suffer from TBI each year, and a considerable number of patients will be temporarily or permanently disabled or even die due to this disease. Astrocytes play a very important role in the repair of brain tissue after TBI, including the formation of a neuroprotective barrier, inhibition of brain edema, and inhibition of normal nerve cell apoptosis. However, the detailed mechanism underlying this protective effect is still unclear. To investigate the regulatory factors of astrocytes to other neurons post-TBI, we established a TBI rat model and used the AAV to mediate the overexpression of GJA1-20k in astrocytes of rats. And functionally, the specific overexpression of GJA1-20k in astrocytes promoted the viability and recovery of neurons in TBI. Mechanistically, the astrocytes-specific upregulation of GJA1-20k protected the function of mitochondria in neurons of FPI rats, thus suppressing the apoptosis of the damaged neurons. We hereby reported that astrocytes-specific overexpression of GJA1-20k enhanced the viability and recovery of the neurons in TBI through regulating their mitochondrial function." @default.
• W3024812093 created "2020-05-21" @default.
• W3024812093 creator A5015886681 @default.
• W3024812093 creator A5017541508 @default.
• W3024812093 creator A5018146732 @default.
• W3024812093 creator A5038431825 @default.
• W3024812093 creator A5039841922 @default.
• W3024812093 creator A5052556650 @default.
• W3024812093 creator A5056455223 @default.
• W3024812093 creator A5075768357 @default.
• W3024812093 creator A5076819152 @default.
• W3024812093 creator A5079613915 @default.
• W3024812093 creator A5080153539 @default.
• W3024812093 creator A5087130734 @default.
• W3024812093 date "2020-05-13" @default.
• W3024812093 modified "2023-10-05" @default.
• W3024812093 title "Overexpression of Astrocytes-Specific GJA1-20k Enhances the Viability and Recovery of the Neurons in a Rat Model of Traumatic Brain Injury" @default.
• W3024812093 cites W1494429900 @default.
• W3024812093 cites W1963709223 @default.
• W3024812093 cites W1976676780 @default.
• W3024812093 cites W1980327051 @default.
• W3024812093 cites W1986649427 @default.
• W3024812093 cites W2001748403 @default.
• W3024812093 cites W2015551349 @default.
• W3024812093 cites W2018681635 @default.
• W3024812093 cites W2023542615 @default.
• W3024812093 cites W2039758887 @default.
• W3024812093 cites W2047206995 @default.
• W3024812093 cites W2058903192 @default.
• W3024812093 cites W2067448822 @default.
• W3024812093 cites W2074661552 @default.
• W3024812093 cites W2077660651 @default.
• W3024812093 cites W2096755534 @default.
• W3024812093 cites W2110614144 @default.
• W3024812093 cites W2127338217 @default.
• W3024812093 cites W2128332802 @default.
• W3024812093 cites W2130668388 @default.
• W3024812093 cites W2142508159 @default.
• W3024812093 cites W2153762721 @default.
• W3024812093 cites W2375344191 @default.
• W3024812093 cites W2550139619 @default.
• W3024812093 cites W2583401467 @default.
• W3024812093 cites W2610592311 @default.
• W3024812093 cites W2620626608 @default.
• W3024812093 cites W2631421980 @default.
• W3024812093 cites W2734511487 @default.
• W3024812093 cites W2754554955 @default.
• W3024812093 cites W2766587554 @default.
• W3024812093 cites W2767344017 @default.
• W3024812093 cites W2805944088 @default.
• W3024812093 cites W2883723054 @default.
• W3024812093 cites W2893248496 @default.
• W3024812093 cites W2896751904 @default.
• W3024812093 cites W4297810568 @default.
• W3024812093 doi "https://doi.org/10.1021/acschemneuro.0c00142" @default.
• W3024812093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32401478" @default.
• W3024812093 hasPublicationYear "2020" @default.
• W3024812093 type Work @default.
• W3024812093 sameAs 3024812093 @default.
• W3024812093 citedByCount "12" @default.
• W3024812093 countsByYear W30248120932021 @default.
• W3024812093 countsByYear W30248120932022 @default.
• W3024812093 countsByYear W30248120932023 @default.
• W3024812093 crossrefType "journal-article" @default.
• W3024812093 hasAuthorship W3024812093A5015886681 @default.
• W3024812093 hasAuthorship W3024812093A5017541508 @default.
• W3024812093 hasAuthorship W3024812093A5018146732 @default.
• W3024812093 hasAuthorship W3024812093A5038431825 @default.
• W3024812093 hasAuthorship W3024812093A5039841922 @default.
• W3024812093 hasAuthorship W3024812093A5052556650 @default.
• W3024812093 hasAuthorship W3024812093A5056455223 @default.
• W3024812093 hasAuthorship W3024812093A5075768357 @default.
• W3024812093 hasAuthorship W3024812093A5076819152 @default.
• W3024812093 hasAuthorship W3024812093A5079613915 @default.
• W3024812093 hasAuthorship W3024812093A5080153539 @default.
• W3024812093 hasAuthorship W3024812093A5087130734 @default.
• W3024812093 hasConcept C104317684 @default.
• W3024812093 hasConcept C118552586 @default.
• W3024812093 hasConcept C127561419 @default.
• W3024812093 hasConcept C169760540 @default.
• W3024812093 hasConcept C190283241 @default.
• W3024812093 hasConcept C25498285 @default.
• W3024812093 hasConcept C2777542381 @default.
• W3024812093 hasConcept C2781017439 @default.
• W3024812093 hasConcept C529278444 @default.
• W3024812093 hasConcept C53227056 @default.
• W3024812093 hasConcept C55493867 @default.
• W3024812093 hasConcept C71924100 @default.
• W3024812093 hasConcept C86803240 @default.
• W3024812093 hasConcept C95444343 @default.
• W3024812093 hasConceptScore W3024812093C104317684 @default.
• W3024812093 hasConceptScore W3024812093C118552586 @default.
• W3024812093 hasConceptScore W3024812093C127561419 @default.
• W3024812093 hasConceptScore W3024812093C169760540 @default.
• W3024812093 hasConceptScore W3024812093C190283241 @default.
• W3024812093 hasConceptScore W3024812093C25498285 @default.
• W3024812093 hasConceptScore W3024812093C2777542381 @default.
• W3024812093 hasConceptScore W3024812093C2781017439 @default.

• next