FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024835605> ?p ?o ?g. }

• W3024835605 abstract "Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan-Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock." @default.
• W3024835605 created "2020-05-21" @default.
• W3024835605 creator A5011279712 @default.
• W3024835605 creator A5014766542 @default.
• W3024835605 creator A5015974810 @default.
• W3024835605 creator A5057271005 @default.
• W3024835605 creator A5058916715 @default.
• W3024835605 creator A5061437219 @default.
• W3024835605 creator A5066425818 @default.
• W3024835605 creator A5071175433 @default.
• W3024835605 creator A5073558180 @default.
• W3024835605 creator A5079952452 @default.
• W3024835605 creator A5086504372 @default.
• W3024835605 date "2020-05-14" @default.
• W3024835605 modified "2023-10-16" @default.
• W3024835605 title "IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study" @default.
• W3024835605 cites W1999325378 @default.
• W3024835605 cites W2004643409 @default.
• W3024835605 cites W2015329932 @default.
• W3024835605 cites W2020257925 @default.
• W3024835605 cites W2151426785 @default.
• W3024835605 cites W2215204057 @default.
• W3024835605 cites W2261043905 @default.
• W3024835605 cites W2280404143 @default.
• W3024835605 cites W2297100503 @default.
• W3024835605 cites W2396212074 @default.
• W3024835605 cites W2524411259 @default.
• W3024835605 cites W2540365220 @default.
• W3024835605 cites W2548889063 @default.
• W3024835605 cites W2593038077 @default.
• W3024835605 cites W2594150871 @default.
• W3024835605 cites W2607202980 @default.
• W3024835605 cites W2608823051 @default.
• W3024835605 cites W2735693033 @default.
• W3024835605 cites W2761040354 @default.
• W3024835605 cites W2801527670 @default.
• W3024835605 cites W2811050830 @default.
• W3024835605 cites W2945148195 @default.
• W3024835605 cites W2998853022 @default.
• W3024835605 cites W3016555942 @default.
• W3024835605 doi "https://doi.org/10.3389/fmed.2020.00186" @default.
• W3024835605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7239994" @default.
• W3024835605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32478085" @default.
• W3024835605 hasPublicationYear "2020" @default.
• W3024835605 type Work @default.
• W3024835605 sameAs 3024835605 @default.
• W3024835605 citedByCount "1" @default.
• W3024835605 crossrefType "journal-article" @default.
• W3024835605 hasAuthorship W3024835605A5011279712 @default.
• W3024835605 hasAuthorship W3024835605A5014766542 @default.
• W3024835605 hasAuthorship W3024835605A5015974810 @default.
• W3024835605 hasAuthorship W3024835605A5057271005 @default.
• W3024835605 hasAuthorship W3024835605A5058916715 @default.
• W3024835605 hasAuthorship W3024835605A5061437219 @default.
• W3024835605 hasAuthorship W3024835605A5066425818 @default.
• W3024835605 hasAuthorship W3024835605A5071175433 @default.
• W3024835605 hasAuthorship W3024835605A5073558180 @default.
• W3024835605 hasAuthorship W3024835605A5079952452 @default.
• W3024835605 hasAuthorship W3024835605A5086504372 @default.
• W3024835605 hasBestOaLocation W30248356051 @default.
• W3024835605 hasConcept C104317684 @default.
• W3024835605 hasConcept C126322002 @default.
• W3024835605 hasConcept C135763542 @default.
• W3024835605 hasConcept C139275648 @default.
• W3024835605 hasConcept C153209595 @default.
• W3024835605 hasConcept C156957248 @default.
• W3024835605 hasConcept C203014093 @default.
• W3024835605 hasConcept C207103383 @default.
• W3024835605 hasConcept C2777628635 @default.
• W3024835605 hasConcept C2778384902 @default.
• W3024835605 hasConcept C44249647 @default.
• W3024835605 hasConcept C50382708 @default.
• W3024835605 hasConcept C54355233 @default.
• W3024835605 hasConcept C71924100 @default.
• W3024835605 hasConcept C86803240 @default.
• W3024835605 hasConcept C90924648 @default.
• W3024835605 hasConceptScore W3024835605C104317684 @default.
• W3024835605 hasConceptScore W3024835605C126322002 @default.
• W3024835605 hasConceptScore W3024835605C135763542 @default.
• W3024835605 hasConceptScore W3024835605C139275648 @default.
• W3024835605 hasConceptScore W3024835605C153209595 @default.
• W3024835605 hasConceptScore W3024835605C156957248 @default.
• W3024835605 hasConceptScore W3024835605C203014093 @default.
• W3024835605 hasConceptScore W3024835605C207103383 @default.
• W3024835605 hasConceptScore W3024835605C2777628635 @default.
• W3024835605 hasConceptScore W3024835605C2778384902 @default.
• W3024835605 hasConceptScore W3024835605C44249647 @default.
• W3024835605 hasConceptScore W3024835605C50382708 @default.
• W3024835605 hasConceptScore W3024835605C54355233 @default.
• W3024835605 hasConceptScore W3024835605C71924100 @default.
• W3024835605 hasConceptScore W3024835605C86803240 @default.
• W3024835605 hasConceptScore W3024835605C90924648 @default.
• W3024835605 hasLocation W30248356051 @default.
• W3024835605 hasLocation W30248356052 @default.
• W3024835605 hasLocation W30248356053 @default.
• W3024835605 hasLocation W30248356054 @default.
• W3024835605 hasLocation W30248356055 @default.
• W3024835605 hasLocation W30248356056 @default.
• W3024835605 hasOpenAccess W3024835605 @default.
• W3024835605 hasPrimaryLocation W30248356051 @default.

• next