Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024851167> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3024851167 endingPage "42" @default.
- W3024851167 startingPage "36" @default.
- W3024851167 abstract "Aim. The study objective was to examine fibrin monomer hemostatic effects in post-traumatic parenchymal hemorrhage in the setting of pharmacologically associated platelet aggregation inhibition. Materials and methods. In the in vivo experimental study on male rabbits, the hemostatic effects of fibrin monomer (FM) (0.25 mg/kg) were evaluated in comparison with tranexamic acid (TA) (15 mg/kg) in post-traumatic parenchymal hemorrhage against the background of preliminary inhibition of platelet aggregation function with acetylsalicylic acid (2.0 mg/kg) and clopidogrel (8.0 mg/kg). Volume and rate of blood loss were estimated, as well as the parameters of the hemostatic system. Results. It has been established that FM versus placebo when administered intravenously 1 hour before the injury can prevent severe bleeding associated with taking antiplatelet agents. The volume of blood loss after FM administration decreased in median by 6.0 times, the rate of blood loss – by 5.9 times, and when using TA – by 2.4 (Р FM -TA < 0.02) and 4.8 times respectively. The hemostatic effects of TA were realized when the hemostatic balance was shifted towards the increased fibrin formation (an increase in the level of D-dimer in the blood plasma). The use of FM was not accompanied by any significant changes in the blood coagulation system. Conclusion. The fibrin monomer at a dose of 0.25 mg/kg i.v. is capable of preventing severe posttraumatic parenchymal bleeding caused by the combined use of drugs with different antiplatelet action. The phenomenon is not completely clear and needs to be analyzed in further research. The mechanism of hemostatic effects associated with FM is currently being studied." @default.
- W3024851167 created "2020-05-21" @default.
- W3024851167 creator A5018056868 @default.
- W3024851167 creator A5026472615 @default.
- W3024851167 creator A5040158448 @default.
- W3024851167 creator A5041232100 @default.
- W3024851167 creator A5052313869 @default.
- W3024851167 creator A5060690300 @default.
- W3024851167 creator A5060883007 @default.
- W3024851167 creator A5062658368 @default.
- W3024851167 creator A5081609962 @default.
- W3024851167 date "2020-04-16" @default.
- W3024851167 modified "2023-10-12" @default.
- W3024851167 title "Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function" @default.
- W3024851167 cites W1582919185 @default.
- W3024851167 cites W1991067485 @default.
- W3024851167 cites W2125015772 @default.
- W3024851167 cites W2338438098 @default.
- W3024851167 cites W2634256582 @default.
- W3024851167 cites W2768018286 @default.
- W3024851167 cites W2921215331 @default.
- W3024851167 cites W2950926159 @default.
- W3024851167 cites W3033032022 @default.
- W3024851167 doi "https://doi.org/10.20538/1682-0363-2020-1-36-42" @default.
- W3024851167 hasPublicationYear "2020" @default.
- W3024851167 type Work @default.
- W3024851167 sameAs 3024851167 @default.
- W3024851167 citedByCount "2" @default.
- W3024851167 countsByYear W30248511672021 @default.
- W3024851167 crossrefType "journal-article" @default.
- W3024851167 hasAuthorship W3024851167A5018056868 @default.
- W3024851167 hasAuthorship W3024851167A5026472615 @default.
- W3024851167 hasAuthorship W3024851167A5040158448 @default.
- W3024851167 hasAuthorship W3024851167A5041232100 @default.
- W3024851167 hasAuthorship W3024851167A5052313869 @default.
- W3024851167 hasAuthorship W3024851167A5060690300 @default.
- W3024851167 hasAuthorship W3024851167A5060883007 @default.
- W3024851167 hasAuthorship W3024851167A5062658368 @default.
- W3024851167 hasAuthorship W3024851167A5081609962 @default.
- W3024851167 hasBestOaLocation W30248511671 @default.
- W3024851167 hasConcept C126322002 @default.
- W3024851167 hasConcept C141071460 @default.
- W3024851167 hasConcept C203014093 @default.
- W3024851167 hasConcept C2778382381 @default.
- W3024851167 hasConcept C2778589496 @default.
- W3024851167 hasConcept C2779637338 @default.
- W3024851167 hasConcept C2909810335 @default.
- W3024851167 hasConcept C2910835652 @default.
- W3024851167 hasConcept C2991743468 @default.
- W3024851167 hasConcept C42219234 @default.
- W3024851167 hasConcept C54173615 @default.
- W3024851167 hasConcept C71924100 @default.
- W3024851167 hasConcept C89560881 @default.
- W3024851167 hasConcept C98274493 @default.
- W3024851167 hasConceptScore W3024851167C126322002 @default.
- W3024851167 hasConceptScore W3024851167C141071460 @default.
- W3024851167 hasConceptScore W3024851167C203014093 @default.
- W3024851167 hasConceptScore W3024851167C2778382381 @default.
- W3024851167 hasConceptScore W3024851167C2778589496 @default.
- W3024851167 hasConceptScore W3024851167C2779637338 @default.
- W3024851167 hasConceptScore W3024851167C2909810335 @default.
- W3024851167 hasConceptScore W3024851167C2910835652 @default.
- W3024851167 hasConceptScore W3024851167C2991743468 @default.
- W3024851167 hasConceptScore W3024851167C42219234 @default.
- W3024851167 hasConceptScore W3024851167C54173615 @default.
- W3024851167 hasConceptScore W3024851167C71924100 @default.
- W3024851167 hasConceptScore W3024851167C89560881 @default.
- W3024851167 hasConceptScore W3024851167C98274493 @default.
- W3024851167 hasIssue "1" @default.
- W3024851167 hasLocation W30248511671 @default.
- W3024851167 hasOpenAccess W3024851167 @default.
- W3024851167 hasPrimaryLocation W30248511671 @default.
- W3024851167 hasRelatedWork W1422856675 @default.
- W3024851167 hasRelatedWork W1964850169 @default.
- W3024851167 hasRelatedWork W2051367795 @default.
- W3024851167 hasRelatedWork W2367433032 @default.
- W3024851167 hasRelatedWork W2376980821 @default.
- W3024851167 hasRelatedWork W2409111498 @default.
- W3024851167 hasRelatedWork W3024603800 @default.
- W3024851167 hasRelatedWork W4206888714 @default.
- W3024851167 hasRelatedWork W4210867346 @default.
- W3024851167 hasRelatedWork W4293800065 @default.
- W3024851167 hasVolume "19" @default.
- W3024851167 isParatext "false" @default.
- W3024851167 isRetracted "false" @default.
- W3024851167 magId "3024851167" @default.
- W3024851167 workType "article" @default.