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- W3024855818 abstract "Objective — to determine the serum levels of cytokeratin‑18 (CK‑18) in patients with non‑alcoholic fatty liver disease (NAFLD) combined with metabolic syndrome (MS), and to evaluate its sensitivity comparing to traditional inflammatory markers.Materials and methods. The examinations involved 84 NAFLD patients with metabolic disorders; the control group consisted of 30 practically healthy persons. In addition to the standard NAFLD and MS examinations, the monitoring was performed for the composition of patients’ bodies, visceral adipose tissue dysfunction by determining the visceral obesity index; concentration of СК‑18, highly sensitive C‑reactive protein (CRP) and tumor necrosis factor a (TNF‑a) by enzyme immunoassay.Results. The increased serum levels of CK‑18 were observed in patients with active systemic inflammation in the liver, even with the normal ALT activity and CRP levels, indicating greater sensitivity of CK‑18 as a potential non‑invasive marker of inflammatory activity compared to the traditional markers. The increased levels of circulating CK‑18 were observed in NAFLD patients with MS with high‑grade fibrosis (F3 — F4), which may be useful in predicting liver fibrosis.Conclusions. Further investigations are required to develop the non‑invasive diagnostic and prognostic models of steatohepatitis and fibrosis in patients with NAFLD against the MS background." @default.
- W3024855818 created "2020-05-21" @default.
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- W3024855818 date "2020-02-29" @default.
- W3024855818 modified "2023-10-17" @default.
- W3024855818 title "Cytokeratin-18 as a pathogenetic factor of progression of non-alcoholic fatty liver disease against the metabolic syndrome background" @default.
- W3024855818 doi "https://doi.org/10.30978/mg-2020-2-5" @default.
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