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- W3024863562 abstract "754 Background: Selective or preferential protection of normal tissues is an attractive and potential approach to improve radiotherapy of cancer patients. Currently, we are using nanotechnology as a tool to intervene biological functions that may enhance the radiation treatment and provide a new approach in radioprotection for cancer patients. The efficacy of cancer radiotherapy is limited by normal-tissue injury in the radiation field. Although the use of precise radiation field sizes and accurate dose planning minimize these unwanted side effects, they still occur in a large percentage of treated patients. The side effects may be too severe and compromise optimal radiation dose delivery and significantly reduce the quality of life of patients. Methods and Results: In preliminary studies, we have identified a radioprotective property of the nanoparticle, cerium oxide (also known as nanoceria). We have shown that nanoceria can render protection against chemical, biological and radiological insults on a variety of cultured cell lines. In the first study, rat astrocytes were treated with 10 Gy radiation in the presence or absence of nanoceria. The results showed that in the presence of the optimal biological dose of 10 nM nanoceria, the rat astrocytes were protected from radiation-induced cell death. In another set of experiments, human normal breast (CRL8798) and breast cancer (MCF-7) cell lines were exposed to up to 5000 nM nanoceria as a single treatment. Interestingly, no nanoceria-induced cytotoxicity was observed. When 10 Gy radiation was administered as single therapy, radiation-induced cell death was observed in both the normal and cancer cell lines. However, when nanoceria was administered in combination with radiation, 10 nM nanoceria protected 99% of only the normal breast cells from radiation-induced cell death. In sharp contrast, human MCF-7 breast cancer cells exposed to the same doses of radiation combined with nanoceria were not protected from radiation-induced cell death. Conclusion: These data suggest that cerium oxide nanoparticles are an effective radioprotectant for normal tissues. Cerium oxide nanoparticles can protect normal but not cancer cells from radiation-induced cell death which will lead to novel approaches for eliminating the undesirable side effects of radiation and will ultimately lead to better efficacy of radiation therapy for cancer patients." @default.
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- W3024863562 date "2007-05-01" @default.
- W3024863562 modified "2023-09-25" @default.
- W3024863562 title "Selective radioprotection of normal tissues by new cerium oxide nanoparticles" @default.
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