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- W3024864379 abstract "Huntington's disease is an autosomal-dominant, neurodegenerative disorder caused by a CAG repeat expansion in exon-1 of the huntingtin gene. Alterations in cholesterol metabolism and distribution have been reported in Huntington's disease, including abnormal interactions between mutant huntingtin and sterol regulatory element-binding proteins, decreased levels of apolipoprotein E/cholesterol/low-density lipoprotein receptor complexes, and alterations in the synthesis of ATP-binding cassette transporter A1. Plasma levels of 24S-hydroxycholestrol, a key intermediary in cholesterol metabolism and a possible marker in neurodegenerative diseases, decreased proportionally to the degree of caudate nucleus atrophy. The interaction of mutant huntingtin with sterol regulatory element-binding proteins is of particular interest given that sterol regulatory element-binding proteins play a dual role: They take part in lipid and cholesterol metabolism, but also in the inflammatory response that induces immune cell migration as well as toxic effects, particularly in astrocytes. This work summarizes current evidence on the metabolic and immune implications of sterol regulatory element-binding protein dysregulation in Huntington's disease, highlighting the potential use of drugs that modulate these alterations. © 2020 International Parkinson and Movement Disorder Society." @default.
- W3024864379 created "2020-05-21" @default.
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- W3024864379 date "2020-05-15" @default.
- W3024864379 modified "2023-10-02" @default.
- W3024864379 title "Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease" @default.
- W3024864379 cites W1066525872 @default.
- W3024864379 cites W1149926701 @default.
- W3024864379 cites W1480691962 @default.
- W3024864379 cites W1487168219 @default.
- W3024864379 cites W1529243021 @default.
- W3024864379 cites W1531569394 @default.
- W3024864379 cites W1551892124 @default.
- W3024864379 cites W1556918753 @default.
- W3024864379 cites W1586450452 @default.
- W3024864379 cites W1602100985 @default.
- W3024864379 cites W1647861543 @default.
- W3024864379 cites W1770378670 @default.
- W3024864379 cites W1821062265 @default.
- W3024864379 cites W1829875280 @default.
- W3024864379 cites W1837885345 @default.
- W3024864379 cites W1963552002 @default.
- W3024864379 cites W1964215406 @default.
- W3024864379 cites W1966066277 @default.
- W3024864379 cites W1966485745 @default.
- W3024864379 cites W1968440938 @default.
- W3024864379 cites W1970156474 @default.
- W3024864379 cites W1973094968 @default.
- W3024864379 cites W1974618081 @default.
- W3024864379 cites W1978804425 @default.
- W3024864379 cites W1982493902 @default.
- W3024864379 cites W1983611512 @default.
- W3024864379 cites W1984212762 @default.
- W3024864379 cites W1985474993 @default.
- W3024864379 cites W1986611577 @default.
- W3024864379 cites W1989479626 @default.
- W3024864379 cites W1991436939 @default.
- W3024864379 cites W1991932125 @default.
- W3024864379 cites W1992478997 @default.
- W3024864379 cites W1993321996 @default.
- W3024864379 cites W1993629125 @default.
- W3024864379 cites W1994447059 @default.
- W3024864379 cites W1996205634 @default.
- W3024864379 cites W1996592124 @default.
- W3024864379 cites W1998510870 @default.
- W3024864379 cites W1999419270 @default.
- W3024864379 cites W2000462578 @default.
- W3024864379 cites W2000581324 @default.
- W3024864379 cites W2003742510 @default.
- W3024864379 cites W2004416488 @default.
- W3024864379 cites W2006116524 @default.
- W3024864379 cites W2006534012 @default.
- W3024864379 cites W2007960303 @default.
- W3024864379 cites W2009616432 @default.
- W3024864379 cites W2009959558 @default.
- W3024864379 cites W2010404670 @default.
- W3024864379 cites W2012960469 @default.
- W3024864379 cites W2013582153 @default.
- W3024864379 cites W2013595777 @default.
- W3024864379 cites W2016097940 @default.
- W3024864379 cites W2022791592 @default.
- W3024864379 cites W2022991915 @default.
- W3024864379 cites W2024815256 @default.
- W3024864379 cites W2025872849 @default.
- W3024864379 cites W2026775975 @default.
- W3024864379 cites W2027703774 @default.
- W3024864379 cites W2030126638 @default.
- W3024864379 cites W2031804766 @default.
- W3024864379 cites W2038083025 @default.
- W3024864379 cites W2039436205 @default.
- W3024864379 cites W2040641918 @default.
- W3024864379 cites W2041139207 @default.
- W3024864379 cites W2042716629 @default.
- W3024864379 cites W2044112693 @default.
- W3024864379 cites W2044873499 @default.
- W3024864379 cites W2046335519 @default.
- W3024864379 cites W2046480466 @default.
- W3024864379 cites W2046607034 @default.
- W3024864379 cites W2048292311 @default.
- W3024864379 cites W2048822173 @default.
- W3024864379 cites W2048958063 @default.
- W3024864379 cites W2050064516 @default.
- W3024864379 cites W2050823452 @default.
- W3024864379 cites W2051634852 @default.
- W3024864379 cites W2052496080 @default.
- W3024864379 cites W2055385665 @default.
- W3024864379 cites W2055998713 @default.
- W3024864379 cites W2058669152 @default.
- W3024864379 cites W2059071540 @default.
- W3024864379 cites W2059249151 @default.
- W3024864379 cites W2060005419 @default.
- W3024864379 cites W2064963955 @default.
- W3024864379 cites W2065144533 @default.
- W3024864379 cites W2067450395 @default.
- W3024864379 cites W2068230856 @default.