FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024884216> ?p ?o ?g. }

• W3024884216 endingPage "030006052092425" @default.
• W3024884216 startingPage "030006052092425" @default.
• W3024884216 abstract "Objective Postoperative neurocognitive disorder (PND) is a main complication that is commonly seen postoperatively in elderly patients. The underlying mechanism remains unclear, although neuroinflammation has been increasingly observed in PND. Atorvastatin is a pleiotropic agent with proven anti-inflammatory effects. In this study, we investigated the effects of atorvastatin on a PND mouse model after peripheral surgery. Material and methods The mice were randomized into five groups. The PND models were established, and an open field test and fear condition test were performed. Hippocampal inflammatory cytokine expression was determined using ELISA. Peroxisome proliferator-activated receptor-gamma (PPARγ) expression in the hippocampus was tested using qRT-PCR and western blot analysis. Results On day 1 after surgery, inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 showed a significant increase in the hippocampus, with prominent cognitive impairment. Atorvastatin treatment improved cognitive function in the mouse model, attenuated neuroinflammation, and increased PPARγ expression in the hippocampus. However, treatment with the PPARγ antagonist GW9662 partially reversed the protective effects of atorvastatin. Conclusions These results indicated that atorvastatin improves several hippocampal functions and alleviates inflammation in PND mice after surgery, probably through a PPARγ-involved signaling pathway." @default.
• W3024884216 created "2020-05-21" @default.
• W3024884216 creator A5005702876 @default.
• W3024884216 creator A5031709630 @default.
• W3024884216 creator A5048730835 @default.
• W3024884216 creator A5061568528 @default.
• W3024884216 creator A5064100733 @default.
• W3024884216 creator A5075222441 @default.
• W3024884216 creator A5078312489 @default.
• W3024884216 date "2020-05-01" @default.
• W3024884216 modified "2023-10-10" @default.
• W3024884216 title "Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice" @default.
• W3024884216 cites W1966037459 @default.
• W3024884216 cites W1983565552 @default.
• W3024884216 cites W2015067996 @default.
• W3024884216 cites W2031692952 @default.
• W3024884216 cites W2046922635 @default.
• W3024884216 cites W2053490104 @default.
• W3024884216 cites W2089405849 @default.
• W3024884216 cites W2092452930 @default.
• W3024884216 cites W2417570742 @default.
• W3024884216 cites W2465673206 @default.
• W3024884216 cites W2507624083 @default.
• W3024884216 cites W2522548771 @default.
• W3024884216 cites W2564377292 @default.
• W3024884216 cites W2606501237 @default.
• W3024884216 cites W2621020647 @default.
• W3024884216 cites W2760984022 @default.
• W3024884216 cites W2792668673 @default.
• W3024884216 cites W2947650400 @default.
• W3024884216 cites W4236243369 @default.
• W3024884216 doi "https://doi.org/10.1177/0300060520924251" @default.
• W3024884216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7232118" @default.
• W3024884216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32412807" @default.
• W3024884216 hasPublicationYear "2020" @default.
• W3024884216 type Work @default.
• W3024884216 sameAs 3024884216 @default.
• W3024884216 citedByCount "6" @default.
• W3024884216 countsByYear W30248842162020 @default.
• W3024884216 countsByYear W30248842162021 @default.
• W3024884216 countsByYear W30248842162022 @default.
• W3024884216 crossrefType "journal-article" @default.
• W3024884216 hasAuthorship W3024884216A5005702876 @default.
• W3024884216 hasAuthorship W3024884216A5031709630 @default.
• W3024884216 hasAuthorship W3024884216A5048730835 @default.
• W3024884216 hasAuthorship W3024884216A5061568528 @default.
• W3024884216 hasAuthorship W3024884216A5064100733 @default.
• W3024884216 hasAuthorship W3024884216A5075222441 @default.
• W3024884216 hasAuthorship W3024884216A5078312489 @default.
• W3024884216 hasBestOaLocation W30248842161 @default.
• W3024884216 hasConcept C104317684 @default.
• W3024884216 hasConcept C118552586 @default.
• W3024884216 hasConcept C11988809 @default.
• W3024884216 hasConcept C126322002 @default.
• W3024884216 hasConcept C134018914 @default.
• W3024884216 hasConcept C148762608 @default.
• W3024884216 hasConcept C169900460 @default.
• W3024884216 hasConcept C170493617 @default.
• W3024884216 hasConcept C172467417 @default.
• W3024884216 hasConcept C187345961 @default.
• W3024884216 hasConcept C2776415932 @default.
• W3024884216 hasConcept C2776885963 @default.
• W3024884216 hasConcept C2776914184 @default.
• W3024884216 hasConcept C2777482532 @default.
• W3024884216 hasConcept C2778690821 @default.
• W3024884216 hasConcept C2781161787 @default.
• W3024884216 hasConcept C55493867 @default.
• W3024884216 hasConcept C71924100 @default.
• W3024884216 hasConcept C86803240 @default.
• W3024884216 hasConcept C87753298 @default.
• W3024884216 hasConcept C98274493 @default.
• W3024884216 hasConceptScore W3024884216C104317684 @default.
• W3024884216 hasConceptScore W3024884216C118552586 @default.
• W3024884216 hasConceptScore W3024884216C11988809 @default.
• W3024884216 hasConceptScore W3024884216C126322002 @default.
• W3024884216 hasConceptScore W3024884216C134018914 @default.
• W3024884216 hasConceptScore W3024884216C148762608 @default.
• W3024884216 hasConceptScore W3024884216C169900460 @default.
• W3024884216 hasConceptScore W3024884216C170493617 @default.
• W3024884216 hasConceptScore W3024884216C172467417 @default.
• W3024884216 hasConceptScore W3024884216C187345961 @default.
• W3024884216 hasConceptScore W3024884216C2776415932 @default.
• W3024884216 hasConceptScore W3024884216C2776885963 @default.
• W3024884216 hasConceptScore W3024884216C2776914184 @default.
• W3024884216 hasConceptScore W3024884216C2777482532 @default.
• W3024884216 hasConceptScore W3024884216C2778690821 @default.
• W3024884216 hasConceptScore W3024884216C2781161787 @default.
• W3024884216 hasConceptScore W3024884216C55493867 @default.
• W3024884216 hasConceptScore W3024884216C71924100 @default.
• W3024884216 hasConceptScore W3024884216C86803240 @default.
• W3024884216 hasConceptScore W3024884216C87753298 @default.
• W3024884216 hasConceptScore W3024884216C98274493 @default.
• W3024884216 hasFunder F4320321001 @default.
• W3024884216 hasIssue "5" @default.
• W3024884216 hasLocation W30248842161 @default.
• W3024884216 hasLocation W30248842162 @default.
• W3024884216 hasLocation W30248842163 @default.
• W3024884216 hasLocation W30248842164 @default.

• next