Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024885744> ?p ?o ?g. }
- W3024885744 abstract "Non-human primates (NHP) provide a unique opportunity to study human neurological diseases, yet detailed characterization of the cell types and transcriptional regulatory features in the NHP brain is lacking. We applied a combinatorial indexing assay, sci-ATAC-seq, as well as single-nuclei RNA-seq, to profile chromatin accessibility in 43,793 single cells and transcriptomics in 11,477 cells, respectively, from prefrontal cortex, primary motor cortex and the primary visual cortex of adult cynomolgus monkey Macaca fascularis. Integrative analysis of these two datasets, resolved regulatory elements and transcription factors that specify cell type distinctions, and discovered area-specific diversity in chromatin accessibility and gene expression within excitatory neurons. We also constructed the dynamic landscape of chromatin accessibility and gene expression of oligodendrocyte maturation to characterize adult remyelination. Furthermore, we identified cell type-specific enrichment of differentially spliced gene isoforms and disease-associated single nucleotide polymorphisms. Our datasets permit integrative exploration of complex regulatory dynamics in macaque brain tissue at single-cell resolution." @default.
- W3024885744 created "2020-05-21" @default.
- W3024885744 creator A5000715158 @default.
- W3024885744 creator A5001144824 @default.
- W3024885744 creator A5001823045 @default.
- W3024885744 creator A5006000280 @default.
- W3024885744 creator A5006035620 @default.
- W3024885744 creator A5009559182 @default.
- W3024885744 creator A5010189175 @default.
- W3024885744 creator A5012251441 @default.
- W3024885744 creator A5013939484 @default.
- W3024885744 creator A5016501148 @default.
- W3024885744 creator A5017549166 @default.
- W3024885744 creator A5017552615 @default.
- W3024885744 creator A5019805990 @default.
- W3024885744 creator A5021663745 @default.
- W3024885744 creator A5026681256 @default.
- W3024885744 creator A5028791293 @default.
- W3024885744 creator A5031590247 @default.
- W3024885744 creator A5031813315 @default.
- W3024885744 creator A5031837487 @default.
- W3024885744 creator A5033817476 @default.
- W3024885744 creator A5037597059 @default.
- W3024885744 creator A5039778990 @default.
- W3024885744 creator A5042631615 @default.
- W3024885744 creator A5045949877 @default.
- W3024885744 creator A5046123241 @default.
- W3024885744 creator A5048636257 @default.
- W3024885744 creator A5049937050 @default.
- W3024885744 creator A5050334079 @default.
- W3024885744 creator A5050424155 @default.
- W3024885744 creator A5050914647 @default.
- W3024885744 creator A5052650365 @default.
- W3024885744 creator A5056936311 @default.
- W3024885744 creator A5058798835 @default.
- W3024885744 creator A5059724724 @default.
- W3024885744 creator A5062059924 @default.
- W3024885744 creator A5062341200 @default.
- W3024885744 creator A5064621178 @default.
- W3024885744 creator A5064984179 @default.
- W3024885744 creator A5066084543 @default.
- W3024885744 creator A5066197284 @default.
- W3024885744 creator A5066737605 @default.
- W3024885744 creator A5067188235 @default.
- W3024885744 creator A5067874194 @default.
- W3024885744 creator A5071037763 @default.
- W3024885744 creator A5074339191 @default.
- W3024885744 creator A5082941033 @default.
- W3024885744 creator A5084138424 @default.
- W3024885744 creator A5085798152 @default.
- W3024885744 creator A5088797126 @default.
- W3024885744 date "2020-05-16" @default.
- W3024885744 modified "2023-10-16" @default.
- W3024885744 title "Single-cell regulatory landscape and disease vulnerability map of adult Macaque cortex" @default.
- W3024885744 cites W1492083415 @default.
- W3024885744 cites W1631320694 @default.
- W3024885744 cites W1835026554 @default.
- W3024885744 cites W1938046568 @default.
- W3024885744 cites W1962423576 @default.
- W3024885744 cites W1968623439 @default.
- W3024885744 cites W1971009462 @default.
- W3024885744 cites W1977218716 @default.
- W3024885744 cites W1992772246 @default.
- W3024885744 cites W1996017914 @default.
- W3024885744 cites W1999574084 @default.
- W3024885744 cites W2002173454 @default.
- W3024885744 cites W2006979538 @default.
- W3024885744 cites W2011389660 @default.
- W3024885744 cites W2014677321 @default.
- W3024885744 cites W2021548599 @default.
- W3024885744 cites W2036897871 @default.
- W3024885744 cites W2040027262 @default.
- W3024885744 cites W2060661559 @default.
- W3024885744 cites W2062159906 @default.
- W3024885744 cites W2064274168 @default.
- W3024885744 cites W2074478109 @default.
- W3024885744 cites W2081770828 @default.
- W3024885744 cites W2082241930 @default.
- W3024885744 cites W2085846978 @default.
- W3024885744 cites W2094659254 @default.
- W3024885744 cites W2101108887 @default.
- W3024885744 cites W2124985265 @default.
- W3024885744 cites W2144191490 @default.
- W3024885744 cites W2158613759 @default.
- W3024885744 cites W2165148901 @default.
- W3024885744 cites W2167320436 @default.
- W3024885744 cites W2169456326 @default.
- W3024885744 cites W2184415921 @default.
- W3024885744 cites W2258332806 @default.
- W3024885744 cites W2271255443 @default.
- W3024885744 cites W2279238409 @default.
- W3024885744 cites W2279350325 @default.
- W3024885744 cites W2332337248 @default.
- W3024885744 cites W2341408485 @default.
- W3024885744 cites W2342313938 @default.
- W3024885744 cites W2402391735 @default.
- W3024885744 cites W2415341492 @default.
- W3024885744 cites W2474899924 @default.
- W3024885744 cites W2548396598 @default.
- W3024885744 cites W2558451800 @default.