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• W3024974757 endingPage "111128" @default.
• W3024974757 startingPage "111128" @default.
• W3024974757 abstract "Nanoparticles (NPs) are being studied due to their potential use as therapeutic and immunomodulatory tools, including their ability to transport antigens with the aim to induce a specific immune response. The production of snake antivenoms (AV) involves several inoculations of venom (V) in the presence of adjuvants (ADJ) to improve the immune response of inoculated animals, causing a decrease in its quality and shelf life. Therefore, it is interesting to develop new strategies for reduce these side effects. For that reason, associating V to NPs to replace conventional ADJ could be a useful tool for future AV production. In this work, nanovenoms (NVs) were generated by the adsorption of Crotalus durissus terrificus (Cdt) V proteins over silica NPs (SiNPs) synthesized according to the Stober method. Microphotographies obtained under Transmission Electron Microscopy (TEM) displayed a protein crown over NPs and Fourier Transform Infrared (FT-IR) presented the expected spectra for NVs resulting from the sum of those exhibited by Cdt V and SiNPs separately. SDS PAGE and immunoblotting assays confirmed the presence of proteins over SiNPs. Furthermore, the different enzymatic activities detected demonstrated that SiNPs were capable of binding V proteins preserving its activity and therefore would keep its native structure. In the same way, the NVs conserve the potential cytotoxic effects present in the V as we observed when culturing THP-1 cells with these complexes. This evidence allows us to infer that developed NVs could be used as a new platform for the production of antisera or for immunomodulatory therapies." @default.
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• W3024974757 date "2020-09-01" @default.
• W3024974757 modified "2023-10-15" @default.
• W3024974757 title "Physicochemical and biological characterization of nanovenoms, a new tool formed by silica nanoparticles and Crotalus durissus terrificus venom" @default.
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• W3024974757 doi "https://doi.org/10.1016/j.colsurfb.2020.111128" @default.
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