Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024976620> ?p ?o ?g. }
- W3024976620 abstract "Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting cancer stem-like cell (CSC) properties that contribute to therapeutic resistance including radioresistance, but the molecular mechanisms in ESCC CSCs are currently unknown. Here, we report that ribosomal S6 protein kinase 4 (RSK4) plays a pivotal role in promoting CSC properties and radioresistance in ESCC. RSK4 was highly expressed in ESCC CSCs and associated with radioresistance and poor survival in patients with ESCC. RSK4 was found to be a direct downstream transcriptional target of ΔNp63α, the main p63 isoform, which is frequently amplified in ESCC. RSK4 activated the β-catenin signaling pathway through direct phosphorylation of GSK-3β at Ser9. Pharmacologic inhibition of RSK4 effectively reduced CSC properties and improved radiosensitivity in both nude mouse and patient-derived xenograft models. Collectively, our results strongly suggest that the ΔNp63α/RSK4/GSK-3β axis plays a key role in driving CSC properties and radioresistance in ESCC, indicating that RSK4 is a promising therapeutic target for ESCC treatment." @default.
- W3024976620 created "2020-05-21" @default.
- W3024976620 creator A5003642180 @default.
- W3024976620 creator A5005706767 @default.
- W3024976620 creator A5006672122 @default.
- W3024976620 creator A5015235892 @default.
- W3024976620 creator A5034031259 @default.
- W3024976620 creator A5035350178 @default.
- W3024976620 creator A5040064586 @default.
- W3024976620 creator A5045905707 @default.
- W3024976620 creator A5046739156 @default.
- W3024976620 creator A5048101049 @default.
- W3024976620 creator A5049712147 @default.
- W3024976620 creator A5054274769 @default.
- W3024976620 creator A5056053058 @default.
- W3024976620 creator A5057209439 @default.
- W3024976620 creator A5059051319 @default.
- W3024976620 creator A5059162155 @default.
- W3024976620 creator A5061467753 @default.
- W3024976620 creator A5065547059 @default.
- W3024976620 creator A5068034380 @default.
- W3024976620 creator A5068705633 @default.
- W3024976620 creator A5071498712 @default.
- W3024976620 creator A5073145430 @default.
- W3024976620 creator A5077972623 @default.
- W3024976620 creator A5080177287 @default.
- W3024976620 creator A5084666411 @default.
- W3024976620 creator A5087541439 @default.
- W3024976620 date "2020-07-13" @default.
- W3024976620 modified "2023-10-17" @default.
- W3024976620 title "Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma" @default.
- W3024976620 cites W1088509254 @default.
- W3024976620 cites W1864956320 @default.
- W3024976620 cites W1920254011 @default.
- W3024976620 cites W1964739066 @default.
- W3024976620 cites W1965395825 @default.
- W3024976620 cites W1968010786 @default.
- W3024976620 cites W1976359234 @default.
- W3024976620 cites W1979498628 @default.
- W3024976620 cites W1992746048 @default.
- W3024976620 cites W1993256844 @default.
- W3024976620 cites W1994242450 @default.
- W3024976620 cites W1994327434 @default.
- W3024976620 cites W1999955117 @default.
- W3024976620 cites W2004878973 @default.
- W3024976620 cites W2012543757 @default.
- W3024976620 cites W2014428158 @default.
- W3024976620 cites W2028955578 @default.
- W3024976620 cites W2030112489 @default.
- W3024976620 cites W2033014144 @default.
- W3024976620 cites W2033182904 @default.
- W3024976620 cites W2035473115 @default.
- W3024976620 cites W2037934612 @default.
- W3024976620 cites W2042625441 @default.
- W3024976620 cites W2042830971 @default.
- W3024976620 cites W2043474049 @default.
- W3024976620 cites W2050964681 @default.
- W3024976620 cites W2052615604 @default.
- W3024976620 cites W2053506834 @default.
- W3024976620 cites W2064854415 @default.
- W3024976620 cites W2067772036 @default.
- W3024976620 cites W2071123870 @default.
- W3024976620 cites W2073052482 @default.
- W3024976620 cites W2080962764 @default.
- W3024976620 cites W2081985759 @default.
- W3024976620 cites W2082353425 @default.
- W3024976620 cites W2092092750 @default.
- W3024976620 cites W2110185475 @default.
- W3024976620 cites W2123122199 @default.
- W3024976620 cites W2135925682 @default.
- W3024976620 cites W2136469817 @default.
- W3024976620 cites W2137303628 @default.
- W3024976620 cites W2139362027 @default.
- W3024976620 cites W2145200068 @default.
- W3024976620 cites W2145826166 @default.
- W3024976620 cites W2151931061 @default.
- W3024976620 cites W2154444715 @default.
- W3024976620 cites W2168067539 @default.
- W3024976620 cites W2176928438 @default.
- W3024976620 cites W2179851135 @default.
- W3024976620 cites W2223504426 @default.
- W3024976620 cites W2258673083 @default.
- W3024976620 cites W2272984102 @default.
- W3024976620 cites W2490441649 @default.
- W3024976620 cites W2520400080 @default.
- W3024976620 cites W2565093786 @default.
- W3024976620 cites W2570401594 @default.
- W3024976620 cites W2593759473 @default.
- W3024976620 cites W2601577871 @default.
- W3024976620 cites W2602970936 @default.
- W3024976620 cites W2604232031 @default.
- W3024976620 cites W2749884966 @default.
- W3024976620 cites W2967538289 @default.
- W3024976620 doi "https://doi.org/10.1172/jci134930" @default.
- W3024976620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7410060" @default.
- W3024976620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32396532" @default.
- W3024976620 hasPublicationYear "2020" @default.
- W3024976620 type Work @default.
- W3024976620 sameAs 3024976620 @default.
- W3024976620 citedByCount "22" @default.