FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024991666> ?p ?o ?g. }

• W3024991666 endingPage "515" @default.
• W3024991666 startingPage "503" @default.
• W3024991666 abstract "Antibody-drug conjugates (ADCs) are an emerging drug format of chemotherapy agents with durable therapeutic efficacy and high target specificity. They are expected to revolutionize current cancer treatment strategies and regimens. Currently, seven ADCs are approved by the U.S. Food and Drug Administration (FDA), and more than 100 ADCs are in clinical trials. ADCs consist of humanized or fully human monoclonal antibodies with extremely potent cytotoxic agents (payloads) attached via chemical linkers. The linker structure and conjugation method markedly influence ADC homogeneity, circulation stability, pharmacokinetics profile, therapeutic window, and treatment outcome. In most prior attempts to improve these parameters, linear chemical linkers were used. A disadvantage of this approach is that only one payload molecule can be incorporated per linker. However, the use of branched linkers that can incorporate multiple payload molecules has not been fully explored. In addition, the most common enzymatically cleavable linker used in current ADCs, while stable in humans, is labile in mouse circulation depending on the conjugation site and linker length. In this paper we describe branched linkers, efficient conjugation methods for constructing homogeneous branched ADCs, and a novel tripeptide linker that retains responsiveness to enzymatic drug release and stability in both mouse and human plasma. We also examine several aspects to be considered for constructing safer and more efficacious next-generation ADCs based on recent advances in the ADC field." @default.
• W3024991666 created "2020-05-21" @default.
• W3024991666 creator A5022743912 @default.
• W3024991666 creator A5069745826 @default.
• W3024991666 date "2020-05-01" @default.
• W3024991666 modified "2023-09-25" @default.
• W3024991666 title "Next-generation Antibody-drug Conjugates (ADCs): Exploring New Frontiers with Chemical Approaches" @default.
• W3024991666 cites W1263616324 @default.
• W3024991666 cites W1524815067 @default.
• W3024991666 cites W1670498114 @default.
• W3024991666 cites W1915856409 @default.
• W3024991666 cites W1921766784 @default.
• W3024991666 cites W1966000502 @default.
• W3024991666 cites W1975553571 @default.
• W3024991666 cites W1979491356 @default.
• W3024991666 cites W1984111577 @default.
• W3024991666 cites W1992175481 @default.
• W3024991666 cites W1997537633 @default.
• W3024991666 cites W1998210183 @default.
• W3024991666 cites W2010363872 @default.
• W3024991666 cites W2013506249 @default.
• W3024991666 cites W2032129634 @default.
• W3024991666 cites W2035714004 @default.
• W3024991666 cites W2036637485 @default.
• W3024991666 cites W2048087821 @default.
• W3024991666 cites W2055973049 @default.
• W3024991666 cites W2056434378 @default.
• W3024991666 cites W2098577546 @default.
• W3024991666 cites W2116150122 @default.
• W3024991666 cites W2116504531 @default.
• W3024991666 cites W2126183505 @default.
• W3024991666 cites W2133029659 @default.
• W3024991666 cites W2153699864 @default.
• W3024991666 cites W2170859088 @default.
• W3024991666 cites W2171368669 @default.
• W3024991666 cites W2233888390 @default.
• W3024991666 cites W2270025323 @default.
• W3024991666 cites W2272264121 @default.
• W3024991666 cites W2288867196 @default.
• W3024991666 cites W2307272104 @default.
• W3024991666 cites W2314772071 @default.
• W3024991666 cites W2326085690 @default.
• W3024991666 cites W2334047504 @default.
• W3024991666 cites W2341089209 @default.
• W3024991666 cites W2416224497 @default.
• W3024991666 cites W2531611585 @default.
• W3024991666 cites W2532758768 @default.
• W3024991666 cites W2549780925 @default.
• W3024991666 cites W2567681842 @default.
• W3024991666 cites W2567887956 @default.
• W3024991666 cites W2581307274 @default.
• W3024991666 cites W2597045666 @default.
• W3024991666 cites W2606786998 @default.
• W3024991666 cites W2634968827 @default.
• W3024991666 cites W2752488863 @default.
• W3024991666 cites W2784636560 @default.
• W3024991666 cites W2787760690 @default.
• W3024991666 cites W2805368971 @default.
• W3024991666 cites W2808751881 @default.
• W3024991666 cites W2809207776 @default.
• W3024991666 cites W2896500324 @default.
• W3024991666 cites W2896749190 @default.
• W3024991666 cites W2898488711 @default.
• W3024991666 cites W2920257759 @default.
• W3024991666 cites W2921407524 @default.
• W3024991666 cites W2923147053 @default.
• W3024991666 cites W2935050335 @default.
• W3024991666 cites W2961257847 @default.
• W3024991666 cites W2981574520 @default.
• W3024991666 cites W2981616732 @default.
• W3024991666 cites W2982411421 @default.
• W3024991666 cites W4249056559 @default.
• W3024991666 doi "https://doi.org/10.5059/yukigoseikyokaishi.78.503" @default.
• W3024991666 hasPublicationYear "2020" @default.
• W3024991666 type Work @default.
• W3024991666 sameAs 3024991666 @default.
• W3024991666 citedByCount "1" @default.
• W3024991666 countsByYear W30249916662021 @default.
• W3024991666 crossrefType "journal-article" @default.
• W3024991666 hasAuthorship W3024991666A5022743912 @default.
• W3024991666 hasAuthorship W3024991666A5069745826 @default.
• W3024991666 hasConcept C111919701 @default.
• W3024991666 hasConcept C134066672 @default.
• W3024991666 hasConcept C134306372 @default.
• W3024991666 hasConcept C158379750 @default.
• W3024991666 hasConcept C159654299 @default.
• W3024991666 hasConcept C161624437 @default.
• W3024991666 hasConcept C185592680 @default.
• W3024991666 hasConcept C197336794 @default.
• W3024991666 hasConcept C203014093 @default.
• W3024991666 hasConcept C21951064 @default.
• W3024991666 hasConcept C2777325958 @default.
• W3024991666 hasConcept C2780035454 @default.
• W3024991666 hasConcept C2780557392 @default.
• W3024991666 hasConcept C31258907 @default.
• W3024991666 hasConcept C33923547 @default.
• W3024991666 hasConcept C41008148 @default.
• W3024991666 hasConcept C542903549 @default.

• next