FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3024998380> ?p ?o ?g. }

• W3024998380 abstract "Fluoxetine is a commonly prescribed antidepressant, and the mechanisms of increased bone fragility with its long-term use remain largely unknown. Here, we show that long-term administration of fluoxetine induces the disruption of sphingolipids metabolism in bone marrow adipose tissue (BMAT)through the inhibition of acid sphingomyelinase (ASM). Similarly, a significant reduction of the bone volume was observed in mice with ASM knockout (Smpd1-/-). In detail, inhibition of ASM by fluoxetine reduces the sphingosine-1-phosphate (S1P) level in bone marrow adipocytes, leading to the increase of receptor activator of nuclear factor-kappa-Β ligand (RANKL) secretion, a key regulator for the activation of osteoclastogenesis and bone loss, through the upregulation of cyclooxygenase-2 and its enzymatic product prostaglandin E2 (COX-2/PGE2). In contrast, overexpression of ASM by cisplatin normalizes fluoxetine-induced RANKL overproduction. Furthermore, we conducted a clinical trial with L-serine, a precursor of sphingolipids biosynthesis. The results show that oral supplementation of L-serine (250 mg//kg/d) prevents the acceleration of bone loss caused by long-term fluoxetine (12 months) in postmenopausal women with major depressive disorder (mean total hip bone mineral density reduction: -2.0% vs -1.1%, P = 0.006). Our study provides new insights and potential treatment strategy on the bone loss caused by long-term use of fluoxetine." @default.
• W3024998380 created "2020-05-21" @default.
• W3024998380 creator A5005874473 @default.
• W3024998380 creator A5015079395 @default.
• W3024998380 creator A5028579545 @default.
• W3024998380 creator A5029791756 @default.
• W3024998380 creator A5033842129 @default.
• W3024998380 creator A5039337764 @default.
• W3024998380 creator A5058207172 @default.
• W3024998380 date "2020-05-12" @default.
• W3024998380 modified "2023-10-18" @default.
• W3024998380 title "Long-term use of fluoxetine accelerates bone loss through the disruption of sphingolipids metabolism in bone marrow adipose tissue" @default.
• W3024998380 cites W1970769119 @default.
• W3024998380 cites W1978016611 @default.
• W3024998380 cites W1981199578 @default.
• W3024998380 cites W1984053258 @default.
• W3024998380 cites W1989736049 @default.
• W3024998380 cites W1990357124 @default.
• W3024998380 cites W1994435180 @default.
• W3024998380 cites W1995525186 @default.
• W3024998380 cites W1999208392 @default.
• W3024998380 cites W2005836587 @default.
• W3024998380 cites W2006960442 @default.
• W3024998380 cites W2015356887 @default.
• W3024998380 cites W2026384865 @default.
• W3024998380 cites W2026813394 @default.
• W3024998380 cites W2034758115 @default.
• W3024998380 cites W2035085407 @default.
• W3024998380 cites W2043531340 @default.
• W3024998380 cites W2053712883 @default.
• W3024998380 cites W2067918231 @default.
• W3024998380 cites W2068071965 @default.
• W3024998380 cites W2073052871 @default.
• W3024998380 cites W2090973045 @default.
• W3024998380 cites W2099872645 @default.
• W3024998380 cites W2112526982 @default.
• W3024998380 cites W2114268291 @default.
• W3024998380 cites W2332273970 @default.
• W3024998380 cites W2342109352 @default.
• W3024998380 cites W2357722399 @default.
• W3024998380 cites W2468309233 @default.
• W3024998380 cites W2481295468 @default.
• W3024998380 cites W2552330831 @default.
• W3024998380 cites W2585649126 @default.
• W3024998380 cites W2591036609 @default.
• W3024998380 cites W2607109883 @default.
• W3024998380 cites W2624337469 @default.
• W3024998380 cites W2625313904 @default.
• W3024998380 cites W2766239534 @default.
• W3024998380 cites W2767727318 @default.
• W3024998380 cites W2768617092 @default.
• W3024998380 cites W2789726732 @default.
• W3024998380 cites W2790742050 @default.
• W3024998380 cites W2791271284 @default.
• W3024998380 cites W2800472668 @default.
• W3024998380 cites W2808166659 @default.
• W3024998380 cites W2884750718 @default.
• W3024998380 cites W2909485022 @default.
• W3024998380 cites W2914059881 @default.
• W3024998380 cites W2950016965 @default.
• W3024998380 cites W2966617158 @default.
• W3024998380 cites W2990765570 @default.
• W3024998380 cites W40565860 @default.
• W3024998380 doi "https://doi.org/10.1038/s41398-020-0819-5" @default.
• W3024998380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7217841" @default.
• W3024998380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32398744" @default.
• W3024998380 hasPublicationYear "2020" @default.
• W3024998380 type Work @default.
• W3024998380 sameAs 3024998380 @default.
• W3024998380 citedByCount "8" @default.
• W3024998380 countsByYear W30249983802021 @default.
• W3024998380 countsByYear W30249983802022 @default.
• W3024998380 countsByYear W30249983802023 @default.
• W3024998380 crossrefType "journal-article" @default.
• W3024998380 hasAuthorship W3024998380A5005874473 @default.
• W3024998380 hasAuthorship W3024998380A5015079395 @default.
• W3024998380 hasAuthorship W3024998380A5028579545 @default.
• W3024998380 hasAuthorship W3024998380A5029791756 @default.
• W3024998380 hasAuthorship W3024998380A5033842129 @default.
• W3024998380 hasAuthorship W3024998380A5039337764 @default.
• W3024998380 hasAuthorship W3024998380A5058207172 @default.
• W3024998380 hasBestOaLocation W30249983801 @default.
• W3024998380 hasConcept C126322002 @default.
• W3024998380 hasConcept C134018914 @default.
• W3024998380 hasConcept C170033053 @default.
• W3024998380 hasConcept C170493617 @default.
• W3024998380 hasConcept C171089720 @default.
• W3024998380 hasConcept C185592680 @default.
• W3024998380 hasConcept C2775864247 @default.
• W3024998380 hasConcept C2776033226 @default.
• W3024998380 hasConcept C2776134451 @default.
• W3024998380 hasConcept C2779428903 @default.
• W3024998380 hasConcept C71924100 @default.
• W3024998380 hasConcept C88045685 @default.
• W3024998380 hasConceptScore W3024998380C126322002 @default.
• W3024998380 hasConceptScore W3024998380C134018914 @default.
• W3024998380 hasConceptScore W3024998380C170033053 @default.
• W3024998380 hasConceptScore W3024998380C170493617 @default.
• W3024998380 hasConceptScore W3024998380C171089720 @default.
• W3024998380 hasConceptScore W3024998380C185592680 @default.

• next