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- W3025004229 abstract "Abstract The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner, the length of HS is not a critical factor for the binding, and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses." @default.
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- W3025004229 date "2020-05-17" @default.
- W3025004229 modified "2023-10-01" @default.
- W3025004229 title "Binding of the SARS-CoV-2 Spike Protein to Glycans" @default.
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- W3025004229 doi "https://doi.org/10.1101/2020.05.17.100537" @default.
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