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• W3025019304 abstract "Background Decision support systems based on reinforcement learning (RL) have been implemented to facilitate the delivery of personalized care. This paper aimed to provide a comprehensive review of RL applications in the critical care setting. Objective This review aimed to survey the literature on RL applications for clinical decision support in critical care and to provide insight into the challenges of applying various RL models. Methods We performed an extensive search of the following databases: PubMed, Google Scholar, Institute of Electrical and Electronics Engineers (IEEE), ScienceDirect, Web of Science, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica Database (EMBASE). Studies published over the past 10 years (2010-2019) that have applied RL for critical care were included. Results We included 21 papers and found that RL has been used to optimize the choice of medications, drug dosing, and timing of interventions and to target personalized laboratory values. We further compared and contrasted the design of the RL models and the evaluation metrics for each application. Conclusions RL has great potential for enhancing decision making in critical care. Challenges regarding RL system design, evaluation metrics, and model choice exist. More importantly, further work is required to validate RL in authentic clinical environments." @default.
• W3025019304 created "2020-05-21" @default.
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• W3025019304 date "2020-07-20" @default.
• W3025019304 modified "2023-10-16" @default.
• W3025019304 title "Reinforcement Learning for Clinical Decision Support in Critical Care: Comprehensive Review" @default.
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• W3025019304 doi "https://doi.org/10.2196/18477" @default.
• W3025019304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7400046" @default.
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