Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025046542> ?p ?o ?g. }
- W3025046542 endingPage "742" @default.
- W3025046542 startingPage "729" @default.
- W3025046542 abstract "What is known and objective Hyperuricemia (HUA) and gout are considerable public health problems because of their increasing incidence and interactions with other diseases. We aimed to evaluate the efficacy and safety of urate-lowering therapies (ULTs) for patients. Methods A systematic literature review was conducted, and a network meta-analysis was performed on the included studies using the Markov Chain Monte Carlo simulation method and a Bayesian statistical framework. We calculated surface under the cumulative ranking curve (SUCRA) values and performed clustered ranking to combine the efficacy and safety results. Results Twenty-two randomized controlled studies were identified for the efficacy analysis, and 20 studies were identified for the safety analysis. Compared with the placebo, the ULTs were efficient and safe. Febuxostat 120 mg/d and allopurinol 200 mg/d had the highest SUCRA scores for efficacy and safety, respectively. Clustered ranking results showed that febuxostat 120 mg/d was the best in terms of efficacy and safety, topiroxostat 120/160 mg/d was similar to febuxostat 80 mg/d in terms of efficacy but safer, and allopurinol was not inferior to topiroxostat. What is new and conclusion Febuxostat had the best efficacy and safety results among the tested agents, and topiroxostat and allopurinol appeared to have fewer adverse events." @default.
- W3025046542 created "2020-05-21" @default.
- W3025046542 creator A5014979192 @default.
- W3025046542 creator A5022386599 @default.
- W3025046542 creator A5048642975 @default.
- W3025046542 creator A5052932317 @default.
- W3025046542 creator A5083201788 @default.
- W3025046542 date "2020-05-13" @default.
- W3025046542 modified "2023-10-14" @default.
- W3025046542 title "Efficacy and safety of urate‐lowering treatments in patients with hyperuricemia: A comprehensive network meta‐analysis of randomized controlled trials" @default.
- W3025046542 cites W1223429048 @default.
- W3025046542 cites W1499216809 @default.
- W3025046542 cites W1561987315 @default.
- W3025046542 cites W1617328014 @default.
- W3025046542 cites W1662589166 @default.
- W3025046542 cites W1973714529 @default.
- W3025046542 cites W1979127707 @default.
- W3025046542 cites W1984635585 @default.
- W3025046542 cites W1986409335 @default.
- W3025046542 cites W1987339529 @default.
- W3025046542 cites W1988110621 @default.
- W3025046542 cites W1989340853 @default.
- W3025046542 cites W2000166571 @default.
- W3025046542 cites W2010699829 @default.
- W3025046542 cites W2021108393 @default.
- W3025046542 cites W2047991430 @default.
- W3025046542 cites W2083739587 @default.
- W3025046542 cites W2101964276 @default.
- W3025046542 cites W2106983312 @default.
- W3025046542 cites W2111255580 @default.
- W3025046542 cites W2114365596 @default.
- W3025046542 cites W2122412537 @default.
- W3025046542 cites W2140939027 @default.
- W3025046542 cites W2146511881 @default.
- W3025046542 cites W2156131531 @default.
- W3025046542 cites W2156142163 @default.
- W3025046542 cites W2170452464 @default.
- W3025046542 cites W2171243007 @default.
- W3025046542 cites W2219425446 @default.
- W3025046542 cites W2252591348 @default.
- W3025046542 cites W2282971264 @default.
- W3025046542 cites W2301386984 @default.
- W3025046542 cites W2316561738 @default.
- W3025046542 cites W2336549647 @default.
- W3025046542 cites W2345129305 @default.
- W3025046542 cites W2513879435 @default.
- W3025046542 cites W2515822527 @default.
- W3025046542 cites W2549211436 @default.
- W3025046542 cites W2587948902 @default.
- W3025046542 cites W2588477808 @default.
- W3025046542 cites W2594369691 @default.
- W3025046542 cites W2617594182 @default.
- W3025046542 cites W2731248060 @default.
- W3025046542 cites W2735705864 @default.
- W3025046542 cites W2736860211 @default.
- W3025046542 cites W2749804175 @default.
- W3025046542 cites W2760493179 @default.
- W3025046542 cites W2761615158 @default.
- W3025046542 cites W2761836300 @default.
- W3025046542 cites W2787359140 @default.
- W3025046542 cites W2789891715 @default.
- W3025046542 cites W2790476331 @default.
- W3025046542 cites W2792922685 @default.
- W3025046542 cites W2793103574 @default.
- W3025046542 cites W2793881698 @default.
- W3025046542 cites W2801547292 @default.
- W3025046542 cites W2803658276 @default.
- W3025046542 cites W2888071826 @default.
- W3025046542 cites W2888964504 @default.
- W3025046542 cites W2890403438 @default.
- W3025046542 cites W2892595374 @default.
- W3025046542 cites W2894190043 @default.
- W3025046542 cites W2899372932 @default.
- W3025046542 cites W2910951675 @default.
- W3025046542 cites W2914070822 @default.
- W3025046542 cites W2969906282 @default.
- W3025046542 cites W2970545733 @default.
- W3025046542 cites W2971008022 @default.
- W3025046542 cites W2972938080 @default.
- W3025046542 cites W2976551763 @default.
- W3025046542 cites W2981452012 @default.
- W3025046542 cites W3000270520 @default.
- W3025046542 cites W4237101852 @default.
- W3025046542 cites W4248403572 @default.
- W3025046542 cites W4249268074 @default.
- W3025046542 cites W58609645 @default.
- W3025046542 doi "https://doi.org/10.1111/jcpt.13156" @default.
- W3025046542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32406077" @default.
- W3025046542 hasPublicationYear "2020" @default.
- W3025046542 type Work @default.
- W3025046542 sameAs 3025046542 @default.
- W3025046542 citedByCount "3" @default.
- W3025046542 countsByYear W30250465422021 @default.
- W3025046542 countsByYear W30250465422022 @default.
- W3025046542 crossrefType "journal-article" @default.
- W3025046542 hasAuthorship W3025046542A5014979192 @default.
- W3025046542 hasAuthorship W3025046542A5022386599 @default.
- W3025046542 hasAuthorship W3025046542A5048642975 @default.