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• W3025047103 abstract "An active loop-extrusion mechanism is regarded as the main out--of--equilibrium mechanism responsible for the structuring of megabase-sized domains in chromosomes. We developed a model to study the dynamics of the chromosome fibre by solving the kinetic equations associated with the motion of the extruder. By averaging out the position of the extruder along the chain, we build an effective equilibrium model capable of reproducing experimental contact maps based solely on the positions of extrusion--blocking proteins. We assessed the quality of the effective model using numerical simulations of chromosomal segments and comparing the results with explicit-extruder models and experimental data." @default.
• W3025047103 created "2020-05-21" @default.
• W3025047103 creator A5036029887 @default.
• W3025047103 creator A5043085394 @default.
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• W3025047103 date "2020-09-23" @default.
• W3025047103 modified "2023-10-01" @default.
• W3025047103 title "Effective model of loop extrusion predicts chromosomal domains" @default.
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• W3025047103 doi "https://doi.org/10.1103/physreve.102.032414" @default.
• W3025047103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33076010" @default.
• W3025047103 hasPublicationYear "2020" @default.
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