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- W3025056512 abstract "Abstract The hippocampus is essential for spatial learning and memory. To assess learning we used contextual fear conditioning (cFC), where animals learn to associate a place with aversive events like foot-shocks. Candidate memory mechanisms for cFC are long-term potentiation and long-term depression, but there is little direct evidence of them operating in the hippocampus in vivo following cFC. Also, little is known about the behavioral state changes induced by cFC. To address these issues, we recorded local field potentials in freely behaving mice by stimulating in the left dorsal CA1 region and recording in the right dorsal CA1 region. Synaptic strength in the commissural pathway was monitored by measuring field excitatory postsynaptic potentials (fEPSPs) before and after cFC. After cFC, the commissural pathway’s synaptic strength was potentiated. Although recordings occurred during the wake phase of the light/dark cycle, the mice slept more in the post-conditioning period than in the pre-conditioning period. Relative to awake periods, in non-rapid eye movement (NREM) sleep the fEPSPs were larger in both pre- and post-conditioning periods. We also found a significant negative correlation between the animal’s speed and fEPSP size. Therefore, to avoid confounds in the fEFSP potentiation estimates, we controlled for speed-related and sleep-related fEPSP changes and still found that cFC induced long-term potentiation, but no significant long-term depression. Synaptic strength changes were not found in the control group that simply explored the fear-conditioning chamber, indicating that exploration of the novel place did not produce the measurable effects caused by cFC. These results show that following cFC, the CA1 commissural pathway is potentiated, likely contributing to the functional integration of the left and right hippocampi in fear memory consolidation. In addition, the cFC paradigm produces significant changes in an animal’s behavioral state, which are observable as proximal changes in sleep patterns." @default.
- W3025056512 created "2020-05-21" @default.
- W3025056512 creator A5013869339 @default.
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- W3025056512 creator A5059972145 @default.
- W3025056512 creator A5061082928 @default.
- W3025056512 creator A5064102981 @default.
- W3025056512 date "2020-05-14" @default.
- W3025056512 modified "2023-10-08" @default.
- W3025056512 title "Fear Conditioning Potentiates the Hippocampal CA1 Commissural Pathway In vivo and Increases Awake Phase Sleep" @default.
- W3025056512 cites W10033903 @default.
- W3025056512 cites W139460844 @default.
- W3025056512 cites W142141443 @default.
- W3025056512 cites W1515711615 @default.
- W3025056512 cites W1527334865 @default.
- W3025056512 cites W1539042965 @default.
- W3025056512 cites W1589061864 @default.
- W3025056512 cites W1612572634 @default.
- W3025056512 cites W1770958704 @default.
- W3025056512 cites W1842212615 @default.
- W3025056512 cites W1920095995 @default.
- W3025056512 cites W1964386492 @default.
- W3025056512 cites W1967277115 @default.
- W3025056512 cites W1967456522 @default.
- W3025056512 cites W1969781703 @default.
- W3025056512 cites W1973294321 @default.
- W3025056512 cites W1974799322 @default.
- W3025056512 cites W1980641375 @default.
- W3025056512 cites W1981495948 @default.
- W3025056512 cites W1983903556 @default.
- W3025056512 cites W1984525878 @default.
- W3025056512 cites W1990940223 @default.
- W3025056512 cites W1996709320 @default.
- W3025056512 cites W1997603362 @default.
- W3025056512 cites W1997679949 @default.
- W3025056512 cites W2000965942 @default.
- W3025056512 cites W2001484935 @default.
- W3025056512 cites W2003046304 @default.
- W3025056512 cites W2008085800 @default.
- W3025056512 cites W2008459537 @default.
- W3025056512 cites W2011200277 @default.
- W3025056512 cites W2013651799 @default.
- W3025056512 cites W2014029250 @default.
- W3025056512 cites W2014851480 @default.
- W3025056512 cites W2015785286 @default.
- W3025056512 cites W2016117011 @default.
- W3025056512 cites W2016302914 @default.
- W3025056512 cites W2023020227 @default.
- W3025056512 cites W2023634197 @default.
- W3025056512 cites W2025670541 @default.
- W3025056512 cites W2026626932 @default.
- W3025056512 cites W2030345583 @default.
- W3025056512 cites W2032074018 @default.
- W3025056512 cites W2032698895 @default.
- W3025056512 cites W2043468320 @default.
- W3025056512 cites W2043487837 @default.
- W3025056512 cites W2044215073 @default.
- W3025056512 cites W2050066016 @default.
- W3025056512 cites W2070368256 @default.
- W3025056512 cites W2071290167 @default.
- W3025056512 cites W2072154498 @default.
- W3025056512 cites W2072766399 @default.
- W3025056512 cites W2073505787 @default.
- W3025056512 cites W2076471532 @default.
- W3025056512 cites W2087298647 @default.
- W3025056512 cites W2087718603 @default.
- W3025056512 cites W2091490195 @default.
- W3025056512 cites W2092867302 @default.
- W3025056512 cites W2093069982 @default.
- W3025056512 cites W2095484045 @default.
- W3025056512 cites W2109257210 @default.
- W3025056512 cites W2109919607 @default.
- W3025056512 cites W2110132657 @default.
- W3025056512 cites W2111354960 @default.
- W3025056512 cites W2120053143 @default.
- W3025056512 cites W2127450768 @default.
- W3025056512 cites W2136104104 @default.
- W3025056512 cites W2138983175 @default.
- W3025056512 cites W2140117942 @default.
- W3025056512 cites W2140201388 @default.
- W3025056512 cites W2146701730 @default.
- W3025056512 cites W2156366271 @default.
- W3025056512 cites W2163795467 @default.
- W3025056512 cites W2169055490 @default.
- W3025056512 cites W2182211053 @default.
- W3025056512 cites W2264706232 @default.
- W3025056512 cites W2274251786 @default.
- W3025056512 cites W2288876215 @default.
- W3025056512 cites W2298376950 @default.
- W3025056512 cites W2343813323 @default.
- W3025056512 cites W2474767020 @default.
- W3025056512 cites W2511883439 @default.
- W3025056512 cites W2561545741 @default.
- W3025056512 cites W2569046604 @default.
- W3025056512 cites W2574596077 @default.
- W3025056512 cites W2604616981 @default.
- W3025056512 cites W2615748991 @default.
- W3025056512 cites W2734327425 @default.
- W3025056512 cites W2735674872 @default.