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• W3025066903 endingPage "66" @default.
• W3025066903 startingPage "45" @default.
• W3025066903 abstract "Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling collective cell migration using quantitative tools and approaches rooted in soft matter physics. We focus on theoretical models of cell aggregates as continuous active media, where the feedback between mechanical forces and regulatory biochemistry gives rise to rich collective dynamical behavior. This class of models provides a powerful predictive framework for the physiological dynamics that underlies many developmental processes, where cells need to collectively migrate like a viscous fluid to reach a target region, and then stiffen to support mechanical stresses and maintain tissue cohesion." @default.
• W3025066903 created "2020-05-21" @default.
• W3025066903 creator A5009058221 @default.
• W3025066903 creator A5028359228 @default.
• W3025066903 date "2019-01-01" @default.
• W3025066903 modified "2023-10-14" @default.
• W3025066903 title "Continuum Models of Collective Cell Migration" @default.
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