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• W3025101235 abstract "Targeted therapy is one of the major treatment modalities in advanced non-small cell lung cancer (NSCLC) with sensitive driver gene mutations. BRAF is considered a promising oncogenic driver in NSCLC after the discovery of epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) fusion and ROS1 rearrangement. BRAF V600E mutation accounts for more than half of BRAF mutations, which is a potential therapeutic target for advanced NSCLC. This review aims to summarize the advancements of BRAF gene mutation and targeted therapy for BRAF mutation in NSCLC. .【中文题目：晚期非小细胞肺癌BRAF突变靶向治疗进展】 【中文摘要：靶向治疗是驱动基因阳性晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）的重要治疗手段之一。鼠类肉瘤病毒癌基因同源物B1（v-raf murine sar-coma viral oncogene homolog B1, BRAF）基因是继表皮生长因子受体（epidermal growth factor receptor, EGFR）基因突变、间变性淋巴瘤激酶（anaplastic lymphoma kinase, ALK）基因融合和ROS1基因重排之后，NSCLC又一个重要的驱动基因。BRAF V600E突变占BRAF基因突变的一半以上，是晚期NSCLC的潜在治疗靶点，本文主要对BRAF基因突变类型及相关靶向研究进展进行综述。 】 【中文关键词：肺肿瘤；鼠类肉瘤病毒癌基因同源物B1；靶向治疗】." @default.
• W3025101235 created "2020-05-21" @default.
• W3025101235 creator A5019840134 @default.
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• W3025101235 date "2018-08-20" @default.
• W3025101235 modified "2023-10-16" @default.
• W3025101235 title "[Research Progress of Targeted Therapy for BRAF Mutation 
in Advanced Non-small Cell Lung Cancer]." @default.
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• W3025101235 doi "https://doi.org/10.3779/j.issn.1009-3419.2018.08.10" @default.
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