Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025101326> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3025101326 abstract "Schistosomiasis is the second most common parasitic infection all over the world. It is responsible for thousands of deaths per year. Control of this infection depends mainly on praziquantel which unfortunately has many defects e.g. occurrence of reinfection and risk of resistance. So, a suitable vaccine is an urgent need. The vaccination that elicits a combined Th1 and Th2 is considered a proper vaccine candidate. Trehalose Dimycolate (TDM) is an immunogen that proved potent activation of Th1 lymphocytes. Effects of its combination with the Th2 stimulant, soluble egg antigen (SEA) in protection against Schistosoma mansoni infection in experimental animals were studied. Combined SAE+TDM achieved statistically significant protection against infection causing reduction of the worm load and ova count. A large percentage of the laid ova were even immature. Combined immunization was associated with reduced hepatic granuloma number, diameter and hepatic fibrosis percentage. Moreover, SEA+TDM increased stimulation of M2 type macrophages that limited the spread of hepatic fibrosis. It was concluded that SEA+TDM achieved the best protection from infection and the resulting pathology.This can be regarded to increased activation of humoral and cellular wings of immunity and activations of both anti-S. mansoni and tissue protecting macrophages and cytokines." @default.
- W3025101326 created "2020-05-21" @default.
- W3025101326 creator A5006936945 @default.
- W3025101326 creator A5021357478 @default.
- W3025101326 creator A5033319202 @default.
- W3025101326 creator A5080941276 @default.
- W3025101326 creator A5084463295 @default.
- W3025101326 date "2020-04-01" @default.
- W3025101326 modified "2023-09-27" @default.
- W3025101326 title "EVALUATION OF PROTECTIVE EFFECTS OF SOLUBLE EGG ANTIGEN CONJUGATED WITH TREHALOSE DIMYCOLATE ADJUVANT IN EXPERIMENTAL SCHISTOSOMIASIS MANSONI" @default.
- W3025101326 doi "https://doi.org/10.21608/jesp.2020.88745" @default.
- W3025101326 hasPublicationYear "2020" @default.
- W3025101326 type Work @default.
- W3025101326 sameAs 3025101326 @default.
- W3025101326 citedByCount "0" @default.
- W3025101326 crossrefType "journal-article" @default.
- W3025101326 hasAuthorship W3025101326A5006936945 @default.
- W3025101326 hasAuthorship W3025101326A5021357478 @default.
- W3025101326 hasAuthorship W3025101326A5033319202 @default.
- W3025101326 hasAuthorship W3025101326A5080941276 @default.
- W3025101326 hasAuthorship W3025101326A5084463295 @default.
- W3025101326 hasBestOaLocation W30251013261 @default.
- W3025101326 hasConcept C142724271 @default.
- W3025101326 hasConcept C147483822 @default.
- W3025101326 hasConcept C159654299 @default.
- W3025101326 hasConcept C165901193 @default.
- W3025101326 hasConcept C203014093 @default.
- W3025101326 hasConcept C22070199 @default.
- W3025101326 hasConcept C2776225656 @default.
- W3025101326 hasConcept C2776863245 @default.
- W3025101326 hasConcept C2777863537 @default.
- W3025101326 hasConcept C2779341262 @default.
- W3025101326 hasConcept C2779744950 @default.
- W3025101326 hasConcept C2779909307 @default.
- W3025101326 hasConcept C2780140890 @default.
- W3025101326 hasConcept C2780559512 @default.
- W3025101326 hasConcept C542903549 @default.
- W3025101326 hasConcept C71924100 @default.
- W3025101326 hasConcept C86803240 @default.
- W3025101326 hasConcept C8891405 @default.
- W3025101326 hasConceptScore W3025101326C142724271 @default.
- W3025101326 hasConceptScore W3025101326C147483822 @default.
- W3025101326 hasConceptScore W3025101326C159654299 @default.
- W3025101326 hasConceptScore W3025101326C165901193 @default.
- W3025101326 hasConceptScore W3025101326C203014093 @default.
- W3025101326 hasConceptScore W3025101326C22070199 @default.
- W3025101326 hasConceptScore W3025101326C2776225656 @default.
- W3025101326 hasConceptScore W3025101326C2776863245 @default.
- W3025101326 hasConceptScore W3025101326C2777863537 @default.
- W3025101326 hasConceptScore W3025101326C2779341262 @default.
- W3025101326 hasConceptScore W3025101326C2779744950 @default.
- W3025101326 hasConceptScore W3025101326C2779909307 @default.
- W3025101326 hasConceptScore W3025101326C2780140890 @default.
- W3025101326 hasConceptScore W3025101326C2780559512 @default.
- W3025101326 hasConceptScore W3025101326C542903549 @default.
- W3025101326 hasConceptScore W3025101326C71924100 @default.
- W3025101326 hasConceptScore W3025101326C86803240 @default.
- W3025101326 hasConceptScore W3025101326C8891405 @default.
- W3025101326 hasLocation W30251013261 @default.
- W3025101326 hasOpenAccess W3025101326 @default.
- W3025101326 hasPrimaryLocation W30251013261 @default.
- W3025101326 hasRelatedWork W13726535 @default.
- W3025101326 hasRelatedWork W1955036 @default.
- W3025101326 hasRelatedWork W1978675 @default.
- W3025101326 hasRelatedWork W2820455 @default.
- W3025101326 hasRelatedWork W3738473 @default.
- W3025101326 hasRelatedWork W4890545 @default.
- W3025101326 hasRelatedWork W5475671 @default.
- W3025101326 hasRelatedWork W6193703 @default.
- W3025101326 hasRelatedWork W6430304 @default.
- W3025101326 hasRelatedWork W7192042 @default.
- W3025101326 isParatext "false" @default.
- W3025101326 isRetracted "false" @default.
- W3025101326 magId "3025101326" @default.
- W3025101326 workType "article" @default.